Pigmented Nevus (Melanocytic Nevus)

A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.

Also Known As:

Networked: 557 relevant articles (18 outcomes, 52 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Melanoma (Melanoma, Malignant)
2.	Nevus (Nevi)
3.	Neurofibroma
4.	Neoplasms (Cancer)
5.	Neoplasm Metastasis (Metastasis)

Experts

1.	Hoang, Mai P: 5 articles (09/2015 - 05/2004)
2.	Altmeyer, Peter: 5 articles (01/2013 - 02/2006)
3.	Garbe, Claus: 5 articles (06/2011 - 04/2004)
4.	Carlson, J Andrew: 5 articles (02/2011 - 01/2002)
5.	Prieto, Victor G: 4 articles (08/2013 - 01/2002)
6.	Gambichler, Thilo: 4 articles (01/2013 - 05/2009)
7.	Bechara, Falk G: 4 articles (01/2013 - 05/2009)
8.	Florell, Scott R: 4 articles (08/2012 - 10/2007)
9.	Bauer, Jürgen: 4 articles (06/2011 - 04/2004)
10.	Slominski, Andrzej: 4 articles (02/2011 - 01/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Pigmented Nevus:

1.	CosmeticsIBA 04/01/2015 - "There is no gold standard for the treatment of benign melanocytic nevi for cosmetic purposes. " 07/01/2000 - "The present study was undertaken to evaluate the cosmetic outcome of deep shave excision of macular melanocytic nevi with the razor blade technique. " 05/01/2015 - "Giant congenital melanocytic nevi (GCMNs) create cosmetic disfigurements and pose risk for malignant transformation. " 08/01/2014 - "Congenital melanocytic nevus (CMN) has an increasing risk of malignancy and may cause cosmetic and psychological problems. " 04/01/2014 - "In cosmetic clinical practice, many patients express the desire for removal of melanocytic nevi, especially those on the face. "
2.	MART-1 AntigenIBA 10/01/2012 - "melanocytic nevi, because of their histopathologic attributes (symmetric silhouette, benign cytologic features) and results from immunohistochemical studies (all lesions strongly expressed Melan-A and p16) and fluorescence in situ hybridization (FISH). " 07/01/2012 - "Our data indicate that Melan-A immunohistochemical staining is helpful in differentiating neurotized melanocytic nevi from neurofibromas when distinction on histomorphology alone is difficult." 07/01/2012 - "All of the melanocytic nevi showed Melan-A staining within the neurotized areas, with most of the areas staining strongly positive, whereas all the neurofibromas were completely absent of Melan-A stain. " 07/01/2012 - "To determine whether Melan-A (MART-1) immunohistochemical stain is sufficient to differentiate neurotized melanocytic nevi from neurofibromas. " 07/01/2012 - "Differentiating neurotized melanocytic nevi from neurofibromas using Melan-A (MART-1) immunohistochemical stain."
3.	Proliferating Cell Nuclear Antigen (PCNA)IBA 04/08/2008 - "89, P < 0.01) and normal skin group (4.0% +/- 2.0%, t = 22.63, P < 0.01), however, there was no significant difference in the PCNA PI between the melanocytic nevus and normal skin groups (P > 0.05). " 04/08/2008 - "The positive index (PI) of PCNA of the MM group was 55.0% +/- 14.8%, significantly higher than those of the melanocytic nevus group (6.2% +/- 3.0%, t = 19. " 04/08/2008 - "The PCNA positive rate of the MM group was 100% (35/35), significantly higher than those of the melanocytic nevus group (33.33%, 7/21) and normal skin group (10.71%, 3/28) (chi2 = 54.4, v = 2, P < 0.01). " 12/01/1998 - "Enhanced expression of Ki-67, topoisomerase IIalpha, PCNA, p53 and p21WAF1/Cip1 reflecting proliferation and repair activity in UV-irradiated melanocytic nevi." 01/01/1993 - "These results indicate that staining with PCNA would be very useful in the differentiation of malignant melanoma from melanocytic nevi manifesting cellular and/or structural atypia by virtue of a significant difference in the proportion of PCNA-positive cells. "
4.	ErbiumIBA 02/01/2006 - "To date, no study has evaluated the efficacy and safety of an erbium:yttrium-aluminum-garnet (YAG) laser, with its small penetration depth and fewer adverse effects, in the treatment of acquired melanocytic nevi. " 04/01/2015 - "To investigate the efficacy and safety of combined treatment with the short-pulsed erbium:yttrium-aluminum-garnet (Er:YAG) and long-pulsed alexandrite laser for acquired melanocytic nevi (AMN) and small congenital melanocytic nevi (CMN). " 01/01/2014 - "Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG]) are more suited to treat acquired melanocytic nevi. " 10/01/2014 - "Effective treatment of congenital melanocytic nevus and nevus sebaceous using the pinhole method with the erbium-doped yttrium aluminium garnet laser."
5.	Ki-67 Antigen (Ki 67 Antigen)IBA 04/30/1998 - "In addition, a greater proportion of cells were immunopositive for Ki67 antigen, p53 and p21WAF1 protein in the primary melanomas than in the benign melanocytic nevi, however, only p53 over-expression was significantly associated with improved survival (P=0.041)." 03/01/1989 - "Monoclonal antibodies (MoAbs) against six well-defined progression-associated melanoma antigens (PAMAs) and a MoAb against the nuclear proliferation-associated antigen Ki67 were used for an immunoperoxidase study on 44 biopsies from 36 congenital melanocytic nevi (CMN). " 10/01/1994 - "Formalin-fixed and paraffin-embedded tissues from 4 cutaneous melanoma metastases, 10 primary invasive melanomas, and 10 intradermal melanocytic nevi were immunolabeled with monoclonal antibodies directed against BCL-2 protein (Dako, clone 124) and Ki-67 antigen (Amac, clone MIB-1), after antigen retrieval techniques. "
6.	Carbon MonoxideIBA 03/01/1989 - "We found expression of single PAMAs and co-expression of PAMAs in CMN in higher frequency than in common acquired melanocytic nevi. " 03/01/2005 - "To determine if the Q-switched alexandrite laser (QSAL) is effective in the treatment of congenital melanocytic nevi, 53 patients with these lesions were treated with QSAL; of these, 16 also received CO(2) laser treatment between QSAL treatments. " 10/01/2015 - "Co-localization of agminated congenital melanocytic nevi with vitiligo vulgaris: an unusual presentation." 10/01/2012 - "The combination of a melanocytic nevus with other tumor of epidermal or adnexal origin has been described before, but still the co-existence of two different neoplasms within a lesion is still uncommon. " 05/01/2012 - "Until recently, the removal of melanocytic nevi has been performed with a CO(2) laser or Er:YAG laser. "
7.	ArgonIBA 02/01/2006 - "To evaluate the efficacy of an argon laser in the ablation of benign conjunctival pigmented nevi. " 02/01/2006 - "The argon-laser ablation of conjunctival pigmented nevi uniformaly resulted in excellent clinical outcomes. " 02/01/2006 - "We conducted argon laser ablations for conjunctival pigmented nevus in 30 eyes of 28 patients. " 02/01/2006 - "Argon laser photoablation of conjunctival pigmented nevus." 05/01/1989 - "The article gives an account of material concerning treatment of 60 patients with pigmented lesions of the skin (capillary hemangiomas, pigmented nevus, tattoos) by exposure to argon laser radiation. "
8.	YttriumIBA 10/01/2014 - "Effective treatment of congenital melanocytic nevus and nevus sebaceous using the pinhole method with the erbium-doped yttrium aluminium garnet laser."
9.	SteroidsIBA 05/01/2015 - "We report on an 11-year-old boy in remission from LCH, treated with only topical steroids, who presented years later with an eruption of melanocytic nevi in the bilateral inguinal and axillary regions. "
10.	ElastinIBA 08/01/2009 - "The distinctive patterns of elastic fibers, best shown by the elastin immunostain, were helpful in evaluating melanomas associated with melanocytic nevi." 08/01/2009 - "We analyzed elastic fiber patterns using elastin immunostain and elastic van Gieson (EVG) stain in 30 cases of invasive melanomas associated with nevi, 12 control melanocytic nevi and 14 control invasive melanomas. "

Therapies and Procedures

1.	Solid-State Lasers 04/01/2015 - "Combined treatment with Er:YAG laser and long-pulsed alexandrite laser is effective for the removal of small benign melanocytic nevi with minimal adverse effects and low recurrence rates." 05/01/1997 - "The Q-switched ruby laser is effective in removing small melanocytic nevi. " 01/01/2014 - "The long-pulsed, 532-nm Nd:YAG laser is safe and effective in the removal of small acquired melanocytic nevi in Yemeni patients." 05/01/2012 - "Use of the 1,064 nm Q-switched Nd:YAG laser is a safe and effective treatment modality for melanocytic nevi." 02/01/2006 - "Short-pulse erbium:YAG laser treatment is an effective and safe method for removing acquired melanocytic nevi."
2.	Lasers (Laser) 01/01/2014 - "Pigment-specific lasers were initially used in the Q-switched mode, which was based on the thermal relaxation time of the melanocyte (size 7 μm; 1 μsec), which is not the primary target in melanocytic nevus. " 01/01/2013 - "The science, reality, and ethics of treating common acquired melanocytic nevi (moles) with lasers." 05/01/2012 - "However, there have been no previous experiments performed to test the efficacy and safety of this laser treatment for melanocytic nevi. " 03/01/2011 - "Today, there is a consensus that melanocytic nevi must not be removed by means of destructive modalities such as laser or electrodessication, since these procedures preclude histopathologic evaluation and may mask malignant transformation. " 12/01/2010 - "Pigment-specific laser technology with green, red, or near-infrared light targets a variety of pigmented lesions such as lentigines, ephelides, café-au-lait macules, and melanocytic nevi as well as tattoos and unwanted hair. "
3.	Laser Therapy (Surgery, Laser) 02/01/1987 - "For instance, congenital melanocytic nevi may be improved, but are incompletely removed by laser surgery. " 01/01/2011 - "New combined laser therapy for small mass of melanocytic nevi on the face." 02/01/2006 - "Laser ablation was applied directly to the conjunctival pigmented nevus in all patients. " 08/01/2004 - "[Controversy in dermatology--laser therapy and melanocytic nevi]." 01/01/2003 - "Laser therapy of giant congenital melanocytic nevi."
4.	Transplants (Transplant) 11/01/2013 - "To investigate and compare the effectiveness of perichondrial cutaneous graft (PCCG) of dorsal auricle for repairing defect after excision of melanocytic nevus in different parts of the face. " 11/01/2013 - "[Effectiveness of perichondrial cutaneous graft of dorsal auricle for repairing facial melanocytic nevus excision defect]." 11/01/2009 - "One patient with a pigmented nevus occupying more than 75 percent of the forehead received an expanded full-thickness skin graft from the lower abdomen. " 02/01/2006 - "Excess melanocytic nevi have been reported in several groups of immunosuppressed patients, including organ transplant recipients. " 02/01/2006 - "Clinical and dermatoscopic fading of post-transplant eruptive melanocytic nevi after suspension of immunosuppressive therapy."
5.	Gas Lasers 08/01/2014 - "Successful treatment of congenital melanocytic nevus on tragus with CO2 laser." 04/01/2013 - "A CO2 laser was considered to be a good alternative for the removal of melanocytic nevus in this area. " 04/01/2007 - "The paper describes a case of a 23-year-old woman, in whom an intradermal pigmented nevus was removed by an excision using a CO2 laser. " 01/01/1998 - "A 44-year-old woman had several congenital melanocytic nevi that were treated with a CO2 laser. " 06/01/2003 - "Carbon dioxide laser dermabrasion for giant congenital melanocytic nevi."