Nevus of Ota

A macular lesion on the side of the FACE, involving the CONJUNCTIVA and EYELIDS, as well as the adjacent facial skin, SCLERA; OCULOMOTOR MUSCLES; and PERIOSTEUM. Histological features vary from those of a MONGOLIAN SPOT to those of a BLUE NEVUS.

Also Known As:

Networked: 98 relevant articles (25 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Nevus (Nevi)
2.	Cicatrix (Scar)
3.	Seborrheic Keratosis
4.	Hypopigmentation (Hypomelanosis)
5.	Cafe-au-Lait Spots (Spot, Cafe-au-Lait)

Experts

1.	Chan, H H: 6 articles (11/2001 - 09/2000)
2.	Kono, T: 4 articles (01/2001 - 09/2000)
3.	Wang, Hong-wei: 3 articles (05/2013 - 10/2003)
4.	Kono, Taro: 3 articles (01/2006 - 07/2002)
5.	Ho, W S: 3 articles (11/2001 - 10/2000)
6.	Leung, R S: 3 articles (01/2001 - 09/2000)
7.	Ying, S Y: 3 articles (11/2000 - 09/2000)
8.	Kim, Won-Serk: 2 articles (01/2015 - 07/2014)
9.	Chang, Sung Eun: 2 articles (06/2013 - 08/2009)
10.	Lee, Woo Jin: 2 articles (06/2013 - 08/2009)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nevus of Ota:

1.	alexandriteIBA 10/01/2000 - "Q-switched 755 nm alexandrite (QS alex) and Q-switched 1064 nm Nd:YAG lasers are effective in the treatment of nevus of Ota. " 11/01/2000 - "Studies on the use of Q-switched alexandrite (QS alex) and QS Nd:YAG lasers in the treatment of nevus of Ota were limited to case reports and small series. " 10/01/2000 - "An in vivo trial comparing the clinical efficacy and complications of Q-switched 755 nm alexandrite and Q-switched 1064 nm Nd:YAG lasers in the treatment of nevus of Ota." 06/01/2015 - "A retrospective analysis of the clinical efficacies of Q-switched Alexandrite and Q-switched Nd:YAG lasers in the treatment of nevus of Ota in Korean patients." 01/01/2003 - "Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nevus of Ota treatment."
2.	NeodymiumIBA 01/01/2015 - "To evaluate the beneficial effects of early treatment of nevus of Ota with a low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. " 10/01/2013 - "Q-switched neodymium-yttrium aluminium-garnet (Q switched Nd-Yag) laser has been used in the treatment of nevus of Ota in all skin types with variable success rate. " 06/01/2015 - "While the Q-switched Alexandrite laser (QSAL) and the Q-switched neodymium: yttrium-aluminum-garnet (QSNY) laser have been widely used in treating nevus of Ota, few studies compared them. " 02/01/2011 - "To evaluate the safety and efficacy of the 1,064-nm Q-switched neodymium-doped yttrium aluminium garnet (QS Nd:YAG) laser for the treatment of Nevus of Ota in two patients with Fitzpatrick skin type (FST) VI. After 4-13 treatment sessions with the 1,064-nm Q-switched Nd:YAG laser with a 4 mm spot size and fluence of 4-4.2 J/cm(2), two patients with FST VI noted substantial improvement in the appearance of the nevi. " 03/01/2011 - "The objective of this study was to compare the efficacy and safety of Q-switched Ruby laser versus Q-switched neodymium:yttrium-aluminium-garnet (Nd:YAG) laser for oculodermal melanosis (Nevus of Ota) birthmarks in a large group of patients. "
3.	YttriumIBA 10/01/2013 - "Q-switched neodymium-yttrium aluminium-garnet (Q switched Nd-Yag) laser has been used in the treatment of nevus of Ota in all skin types with variable success rate. " 02/01/2011 - "To evaluate the safety and efficacy of the 1,064-nm Q-switched neodymium-doped yttrium aluminium garnet (QS Nd:YAG) laser for the treatment of Nevus of Ota in two patients with Fitzpatrick skin type (FST) VI. After 4-13 treatment sessions with the 1,064-nm Q-switched Nd:YAG laser with a 4 mm spot size and fluence of 4-4.2 J/cm(2), two patients with FST VI noted substantial improvement in the appearance of the nevi. " 03/01/2011 - "The objective of this study was to compare the efficacy and safety of Q-switched Ruby laser versus Q-switched neodymium:yttrium-aluminium-garnet (Nd:YAG) laser for oculodermal melanosis (Nevus of Ota) birthmarks in a large group of patients. "
4.	CosmeticsIBA 12/01/1999 - "Ota's nevus is a dermal melanocytic disease which causes serious cosmetic problems for affected individuals. " 01/01/1989 - "An effective cosmetic treatment for Ota's nevus." 10/01/2011 - "Scleral allograft overlay is a safe and effective procedure for cosmetic improvement of nevus of Ota." 10/01/2011 - "Cosmetic improvement of nevus of Ota by scleral allograft overlay." 03/01/1997 - "Satisfactory cosmetic results were achieved after Q-switched ruby laser therapy for nevus of Ota."
5.	yttrium-aluminum-garnetIBA 01/01/2015 - "To evaluate the beneficial effects of early treatment of nevus of Ota with a low-fluence 1,064-nm Q-switched neodymium-doped yttrium aluminum garnet (Nd:YAG) laser. " 08/01/1995 - "Argon and Q-switched yttrium-aluminum-garnet laser treatment of nevus of Ota." 06/01/2015 - "While the Q-switched Alexandrite laser (QSAL) and the Q-switched neodymium: yttrium-aluminum-garnet (QSNY) laser have been widely used in treating nevus of Ota, few studies compared them. " 08/01/1995 - "Twenty patients with nevus of Ota have been treated with the argon laser, Q-switched yttrium-aluminum-garnet (YAG) laser, or a combination of both lasers. " 06/01/2013 - "We report on the formation of new melasma lesions in a patient who was treated for acquired bilateral nevus of Ota-like macules (ABNOM) with a high-fluence 1064 nm Q-switched (QS) neodymium-doped yttrium aluminum garnet (Nd/YAG) laser."
6.	Melanins (Melanin)IBA 10/27/1976 - "Histopathological examination revealed that the lesion was composed of Ota's nevus-like changes in the epidermis to the middermis and of proliferation of neurofibromatous tissues coexisting with melanin-producing cells in the lower dermis to the subcutaneous adipose tissue. " 10/01/2013 - "To evaluate the utility of melanin index in assessing the treatment response and also determine the efficacy and safety of the Q-switched Nd-Yag laser (1064-nm) in the treatment of nevus of Ota in Fitzpatrick skin types IV and V. A total of 35 patients treated with Nd-Yag laser were studied. " 10/01/2013 - "Melanin Index in Assessing the Treatment Efficacy of 1064 nm Q Switched Nd-Yag Laser in Nevus of Ota." 07/01/1992 - "Disorders of pigmentation can result from either an abnormal number of melanocytes, as in nevus of Ota and vitiligo, or an abnormal amount of melanin production, as in albinism. "
7.	ArgonIBA 05/01/1989 - "Several reports have been published over the last two decades describing the successful removal of benign cutaneous pigmented lesions such as lentigines, café au lait macules' nevi, nevus of Ota, and lentigo maligna by a variety of lasers such as the excimer (351 nm), argon (488,514 nm), ruby (694 nm), Nd:YAG (1060 nm), and CO2 (10,600 nm). " 08/01/1995 - "Argon and Q-switched yttrium-aluminum-garnet laser treatment of nevus of Ota." 08/01/1995 - "Twenty patients with nevus of Ota have been treated with the argon laser, Q-switched yttrium-aluminum-garnet (YAG) laser, or a combination of both lasers. " 01/01/1989 - "The congenital facial melanocytic lesion Ota's nevus is reviewed, and an effective cosmetic treatment--sequential dry ice application and epidermal peeling combined with argon laser--is discussed. "
8.	Dry IceIBA 12/01/1998 - "However, for Ota's nevus previously treated with dry ice cryotherapy (carbon dioxide snow), dermabrasion, free skin grafting, or other methods, therapy is still a challenge, even with the ruby laser. " 01/01/1989 - "The congenital facial melanocytic lesion Ota's nevus is reviewed, and an effective cosmetic treatment--sequential dry ice application and epidermal peeling combined with argon laser--is discussed. "
9.	Uveal melanomaIBA 09/01/2001 - "A 59-year-old patient presented with metastatic uveal melanoma that developed in a nevus of Ota. " 05/01/2010 - "Although nevus of Ota is a risk factor for uveal melanoma in white people, the development of cutaneous melanoma within nevus of Ota is a very rare occurrence with only a few reported cases. "
10.	Progesterone Receptors (Progesterone Receptor)IBA 02/01/2010 - "Androgen, estrogen and progesterone receptors in acquired bilateral nevus of Ota-like macules."

Therapies and Procedures

1.	Solid-State Lasers 10/01/2011 - "The Q-switched alexandrite laser (QSAL) has been clinically proven to be effective in treating nevus of Ota, but a large-scale retrospective study with long-term follow-up has never been performed. " 12/01/1999 - "Q-switched alexandrite laser is a very effective and safe tool for treating Ota's nevus. " 10/01/2013 - "The 1064-nm Q-switched Nd-Yag laser offers good improvement in patients with nevus of Ota in darker skin types IV/V." 08/01/2009 - "The Q-switched Nd:YAG laser (QSNYL) has been used successfully to treat a variety of benign, dermal, pigmented lesions, including nevus of Ota lesions. " 06/01/2006 - "In our experience, the dark rings associated with conventional nevus of Ota can be successfully treated with Q-switched ruby laser (QSRL). "
2.	Lasers (Laser) 03/01/2012 - "Are Q-switched lasers for Nevus of Ota really effective in pigmented skin?" 01/01/2003 - "Pre- and post-operative skin cooling is effective in improving the tolerability of nevus of Ota patients to Q-switched laser treatment. " 01/01/1999 - "Different types of Q-switched lasers have been found to be effective in the treatment of nevus of Ota. " 10/01/2011 - "To evaluate the efficacy of the QSAL in treating nevus of Ota, the laser's long-term side effects, complications associated with the treatments, and the recurrence rate. " 08/01/2014 - "To retrospectively study laser treatment of nevus of Ota in children. "
3.	Dermabrasion 06/01/1996 - "Dermabrasion is an effective treatment for acquired bilateral nevus of Ota-like macules." 06/01/1996 - "Dermabrasion is an excellent modality for the treatment of acquired nevus of Ota-like macules." 02/01/1995 - "Treatment of nevus of Ota with autologous-cultured epithelium grafting combined with dermabrasion." 12/01/1998 - "However, for Ota's nevus previously treated with dry ice cryotherapy (carbon dioxide snow), dermabrasion, free skin grafting, or other methods, therapy is still a challenge, even with the ruby laser. "
4.	Homologous Transplantation (Allograft) 10/01/2011 - "To report surgical outcome of a new therapeutic technique for nevus of Ota by scleral allograft overlay. " 10/01/2011 - "Scleral allograft overlay is a safe and effective procedure for cosmetic improvement of nevus of Ota." 10/01/2011 - "Cosmetic improvement of nevus of Ota by scleral allograft overlay."
5.	Laser Therapy (Surgery, Laser) 11/01/2015 - "Hypertrophied vascular lesions and pigmented lesions, such as the nevus of Ota, respond more effectively to laser therapy earlier in life with fewer treatment sessions and reduced side effects. " 11/01/2001 - "Our data suggest a useful model for evaluating physiologic skin changes after laser surgery in patients with nevus of Ota." 07/01/2001 - "Combined laser therapy has been performed in 47 patients with nevus of Ota since 1995. " 01/01/2006 - "Since 1993, we have performed laser surgery for cutaneous lesions, such as simple hemangioma and nevus of Ota, in children under ambulatory anesthesia. " 03/01/2015 - "In this contribution, we review treatment of periocular pigmented lesions, including melanocytic nevi and nevus of Ota; vascular lesions including telangiectasias, port wine stains, and infantile hemangiomas; hair removal; eyeliner tattoo removal; laser ablation of common benign periocular tumors, such as syringomas, xanthelasma, milia, and seborrheic keratoses; and laser resurfacing. "