Neurotensin

A biologically active tridecapeptide isolated from the hypothalamus. It has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as both a peripheral and a central nervous system neurotransmitter.

Networked: 774 relevant articles (12 outcomes, 78 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Forgez, Patricia: 13 articles (09/2014 - 07/2002)
2.	Richelson, Elliott: 13 articles (06/2014 - 01/2002)
3.	Evers, B Mark: 11 articles (09/2015 - 07/2004)
4.	Pothoulakis, Charalabos: 11 articles (07/2015 - 06/2003)
5.	Carraway, Robert E: 11 articles (04/2008 - 11/2003)
6.	Boules, Mona: 10 articles (03/2014 - 01/2002)
7.	Theoharides, Theoharis C: 9 articles (02/2015 - 07/2005)
8.	Rozengurt, Enrique: 9 articles (01/2013 - 01/2002)
9.	Dobner, Paul R: 8 articles (03/2015 - 08/2004)
10.	Tourwé, Dirk: 8 articles (07/2011 - 03/2002)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 11/01/2010 - "Much evidence suggests that targeting the neurotensin (NT) system may provide a novel and promising treatment for schizophrenia. " 12/05/2013 - "Recent studies have found that the neurotensin NTS1 receptor agonist and putative atypical antipsychotic drug PD149163 reverses deficits in sensory-gating and novel object recognition, suggesting that this compound may have the potential to improve cognitive functioning in schizophrenia. " 01/01/1997 - "This study examined the effects of neurotensin infused into the nucleus accumbens on prepulse inhibition (PPI) of the rat's acoustic startle reflex, a measure which is relevant to the sensorimotor gating deficits seen in schizophrenia. " 01/01/2010 - "Converging evidence has implicated endogenous neurotensin (NT) in the pathophysiology of brain processes relevant to schizophrenia. " 07/01/2009 - "The potential of neurotensin agonists as putative treatments for cognitive deficits of schizophrenia was also supported."
2.	Neoplasms (Cancer) 10/21/2015 - "1,2,3-Triazole Stabilized Neurotensin-Based Radiopeptidomimetics for Improved Tumor Targeting." 08/19/2009 - "The aim of the present study was to design and synthesize new neurotensin radioligands and to select a lead molecule with high in vivo tumor selectivity for further development. " 04/01/1986 - "Plasma neurotensin levels may be of value as a tumor marker, but further studies are necessary to substantiate this theory." 11/01/2015 - "Evaluation of DOTA-chelated neurotensin analogs with spacer-enhanced biological performance for neurotensin-receptor-1-positive tumor targeting." 10/21/2015 - "Neurotensin (NT) is a regulatory peptide with nanomolar affinity toward NT receptors, which are overexpressed by different clinically relevant tumors. "
3.	Hypothermia 11/12/2013 - "We suggest that pharmacological hypothermia using the newly developed neurotensin analogs is a promising therapeutic treatment for ICH." 01/01/1994 - "Although central administration of neurotensin is known to produce marked hypothermia in the rat, there are no studies which have investigated the effects of neurotensin on oxygen consumption and heat exchange, the physiological mechanisms which are the principal contributors to changes in body temperature. " 03/26/1986 - "In this study, prior adaptation to a cold environment was found to significantly antagonize the hypothermia produced by intracisternally-administered neurotensin in mice. " 07/10/1984 - "In this study it was found that hypothermia was most successfully evoked following neurotensin injection along the midline of the ventral mesencephalon, corresponding to the nucleus linearis centralis. " 10/01/2007 - "Intracerebroventricular administration of the tridecapeptide neurotensin is known to elicit hypothermia in rodents for few hours. "
4.	Parkinson Disease (Parkinson's Disease) 12/01/2006 - "These data indicate that the neurotensin polyplex holds great promise for the neuroprotective therapy of Parkinson disease." 01/11/1991 - "The aim of the present study was to examine the effects of neurotensin in an animal model of Parkinson's disease (PD). " 01/01/2009 - "Based on the excitatory effects of neurotensin in globus pallidus of parkinsonian rats, we hypothesize that the pallidal neurotensinergic system may be involved in its possible therapy in Parkinson's disease." 06/01/2001 - "Increased plasma neurotensin concentrations in patients with Parkinson's disease." 06/01/1996 - "Neurotensin levels were increased in the substantia nigra in Parkinson's disease. "
5.	Colitis 07/01/2015 - "Neurotensin--regulated miR-133α is involved in proinflammatory signalling in human colonic epithelial cells and in experimental colitis." 05/26/2009 - "Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis." 02/28/2008 - "Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats." 12/01/2014 - "The expression of neurotensin (NT) and its receptor (NTR1) is up-regulated in experimental colitis and inflammatory bowel disease; NT/NTR1 interactions regulate gut inflammation. " 02/28/2008 - "To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. "

Related Drugs and Biologics

1.	Neuropeptides
2.	SR 48692
3.	Antipsychotic Agents (Antipsychotics)
4.	neurotensin 69L
5.	MicroRNAs (MicroRNA)
6.	telmisartan (Micardis)
7.	Neuropeptide Y
8.	Somatostatin (Somatotropin Release-Inhibiting Factor)
9.	Bombesin
10.	Neurotensin Receptors (Neurotensin Receptor)

Related Therapies and Procedures

1.	Induced Hypothermia
2.	Analgesia
3.	Injections
4.	Enteral Nutrition (Feeding, Tube)
5.	Heterologous Transplantation (Xenotransplantation)