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Neurosyphilis (General Paresis of the Insane)

Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
Also Known As:
General Paresis of the Insane; Central Nervous System Syphilis; General Paralysis; General Paralysis of the Insane; Neurosyphilis, Asymptomatic; Neurosyphilis, Gummatous; Neurosyphilis, Juvenile; Neurosyphilis, Secondary; Neurosyphilis, Symptomatic; Paralysis, General; Secondary Neurosyphilis; Syphilis, CNS; General Paresis; Juvenile Paresis; Paretic Neurosyphilis; Syphilis, Central Nervous System
Networked: 931 relevant articles (57 outcomes, 77 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Syphilis
2. Coinfection
3. Seizures (Absence Seizure)
4. HIV Infections (HIV Infection)
5. tertiary Syphilis

Experts

1. Marra, Christina M: 13 articles (01/2021 - 02/2004)
2. Liu, Li-Li: 11 articles (01/2022 - 04/2013)
3. Guan, Zhifang: 10 articles (01/2022 - 08/2012)
4. Zhou, Pingyu: 10 articles (01/2022 - 08/2012)
5. Lin, Li-Rong: 10 articles (12/2021 - 04/2013)
6. Lu, Haikong: 9 articles (01/2022 - 08/2012)
7. Yang, Tian-Ci: 9 articles (01/2022 - 04/2013)
8. Tantalo, Lauren C: 9 articles (01/2021 - 10/2008)
9. Shi, Mei: 8 articles (01/2022 - 01/2014)
10. Wang, Cuini: 8 articles (01/2022 - 11/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurosyphilis:
1. Penicillins (Penicillin)FDA Link
2. Anti-Bacterial Agents (Antibiotics)IBA
3. Penicillin G (Benzylpenicillin)FDA LinkGeneric
4. ReaginsIBA
5. AntibodiesIBA
6. Penicillin G Benzathine (Benzathine Benzylpenicillin)FDA Link
7. Retinaldehyde (Retinal)IBA
8. Proteins (Proteins, Gene)FDA Link
9. Ceftriaxone (Ceftriaxon)FDA LinkGeneric
10. Doxycycline (Periostat)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Aftercare (After-Treatment)
3. Induced Hyperthermia (Thermotherapy)
4. Drug Therapy (Chemotherapy)
5. Highly Active Antiretroviral Therapy (HAART)