Neurophysins (Neurophysin I)

Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).

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Networked: 188 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Mergen, Hatice: 3 articles (12/2021 - 12/2012)
2.	Oiso, Y: 3 articles (03/2014 - 08/2000)
3.	Karaduman, Tugce: 2 articles (12/2021 - 12/2015)
4.	Saglar, Emel: 2 articles (12/2015 - 12/2012)
5.	Maghnie, Mohamad: 2 articles (04/2015 - 07/2005)
6.	Ki, Chang-Seok: 2 articles (12/2014 - 01/2008)
7.	Arima, H: 2 articles (03/2014 - 07/2010)
8.	Rutishauser, Jonas: 2 articles (02/2011 - 05/2002)
9.	Antunes-Rodrigues, Jose: 2 articles (03/2010 - 10/2003)
10.	Elias, Lucila L K: 2 articles (03/2010 - 10/2003)

Related Diseases

1.	Dehydration (Water Stress) 05/01/1977 - "Water-loading caused a significant reduction in neurophysin, 2.8 +/- 0.1 ng/ml, while hypertonic saline and dehydration caused a significant elevation, 10.4 +/- 2.1 and 8.0 +/- 1.4 ng/ml, respectively. " 10/01/1979 - "Dehydration, water loading, and hemorrhage produced small but significant changes in plasma AVP concentrations without changes in the individual human neurophysins. " 01/01/1987 - "Relative to homogenates of control neural lobes, the extent of conversion of the oxytocin neurophysin is increased in neural lobes from animals of larger size, in secretory granules of greater than the mean density, and in the neural lobes taken from animals during the early stage of dehydration. " 02/01/1978 - "The depletion of neurophysin and vasopressin from the neural lobe and the alterations of several indices of dehydration in the blood of the hamster were less than those found in the rat upon saline imbibition, suggesting that the hamster has a greater ability to adapt to conditions in which water is scarce." 10/01/1971 - "2. Three of the proteins were tentatively identified as neurophysins by their acidic nature and their disappearance after dehydration of the animals. "
2.	Chronic Kidney Failure (Chronic Renal Failure) 10/01/1987 - "High-performance liquid chromatographic characterization of neurophysins in chronic renal failure." 09/01/1972 - "[Modification of the level of serum neurophysin during chronic renal failure]." 01/01/1983 - "Estrogen-stimulated neurophysin in chronic renal failure." 03/01/1979 - "Plasma neurophysin I and II levels were both significantly elevated in fourteen patients with chronic renal failure and rose over haemodialysis, suggesting that the kidney may be the major route of clearance of the neurophysins. " 01/01/1983 - "Estrogen-stimulated neurophysin (ESN) was determined by radioimmunoassay in three groups of patients with chronic renal failure: predialysis patients, patients on hemodialysis and patients on continuous ambulatory peritoneal dialysis. "
3.	Renal Insufficiency (Renal Failure) 09/01/1974 - "[Urinary clearance of neurophysin 1 in a patient with renal insufficiency]."
4.	Kidney Diseases (Kidney Disease) 03/01/1978 - "It is shown that the raised levels of neurophysins observed in the serum of some patients with kidney disease are not attributable to a decrease in the urinary clearance of neurophysins." 03/01/1978 - "The increased rate of urinary excretion of neurophysins observed in some patients with kidney disease therefore appears to be related to a disorder of renal tubular function. " 03/01/1978 - "The mean rate of excretion of neurophysins in the urine of 16 patients with kidney disease but without tubular dysfunction was 0.48 +/- 0.14 (S.E.M.) ng/min, whereas the rate in 16 patients with tubular dysfunction was 3.64 +/- 1.56 ng/min (significantly different; 2P less than 0.01). " 03/01/1978 - "Urinary excretion of neurophysins in patients with kidney disease."
5.	Diabetes Insipidus 11/24/1976 - "In order to study the subcellular distribution of neurophysin in the rat with hypothalamic hereditary diabetes insipidus (DI), an immunoelectron microscopic localization of neurophysin was performed in the hypothalamo-neurohypophysial system of both homozygous and heterozygous DI rats. " 08/10/2001 - "Effects of diabetes insipidus mutations on neurophysin folding and function." 10/01/1987 - "Three of the six cats presented no paradoxical sleep (PS) impairment, despite an almost total destruction of neurophysin-immunoreactive cells of PVN in two cats and marked signs of diabetes insipidus in the third. " 09/01/1987 - "Damage to the neurophysin-containing cells of the hypothalamus explains the various degrees of clinically observed diabetes insipidus." 08/15/1986 - "Anti-neurophysin serum was applied in the immunohistochemical technique to anterior pituitary tissues obtained from normal and chronically dehydrated rats and also from rats with chronic diabetes insipidus (Brattleboro strain). "

Related Drugs and Biologics

1.	Neurophysins (Neurophysin I)
2.	Vasopressins (Vasopressin)
3.	Antibodies
4.	Arginine Vasopressin (Argipressin)
5.	Nicotine
6.	Vasopressin Receptors (Arginine Vasopressin Receptor)
7.	Tumor Biomarkers (Tumor Markers)
8.	Aquaporins (Water Channels)
9.	Posterior Pituitary Hormones
10.	Peptides (Polypeptides)

Related Therapies and Procedures

1.	Therapeutics
2.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
3.	Intravenous Injections
4.	Renal Dialysis (Hemodialysis)
5.	Adrenalectomy