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Acoustic Neuroma (Acoustic Neurinoma)

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A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)

Also Known As:

Acoustic Neurinoma; Vestibular Schwannoma; Acoustic Neuromas; Acoustic Schwannomas; Neuroma, Acoustic; Acoustic Neuroma, Cerebellopontine Angle; Acoustic Tumor; Angle Tumor; Cerebellopontine Angle Acoustic Neuroma; Cerebellopontine Angle Tumor; Neurilemmoma, Acoustic; Neurilemoma, Acoustic; Neurinoma of the Acoustic Nerve; Neurinoma, Acoustic; Neuroma, Acoustic, Unilateral; Acoustic Neurilemmoma; Acoustic Neurilemmomas; Acoustic Neurilemoma; Acoustic Neurilemomas; Acoustic Neurinomas; Acoustic Schwannoma; Acoustic Tumors; Angle Tumor, Cerebellopontine; Angle Tumors; Angle Tumors, Cerebellopontine; Cerebellopontine Angle Tumors; Melanocytic Vestibular Schwannomas; Neurilemmomas, Acoustic; Neurilemomas, Acoustic; Neurinomas, Acoustic; Neuromas, Acoustic; Schwannoma, Melanocytic Vestibular; Schwannomas, Acoustic; Schwannomas, Melanocytic Vestibular; Schwannomas, Vestibular; Tumor, Acoustic; Tumor, Angle; Tumor, Cerebellopontine Angle; Tumors, Acoustic; Tumors, Angle; Tumors, Cerebellopontine Angle; Vestibular Schwannoma, Melanocytic; Vestibular Schwannomas; Vestibular Schwannomas, Melanocytic; Melanocytic Vestibular Schwannoma; Schwannoma, Acoustic; Schwannoma, Vestibular

Networked: 1021 relevant articles (59 outcomes, 100 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Neurofibromatosis 2 (Neurofibromatosis Type II)
3.	Acoustic Neuroma (Acoustic Neurinoma)
4.	Pituitary Neoplasms (Pituitary Adenoma)
5.	Neurilemmoma (Schwannoma)

Experts

1.	Wu, Hao: 11 articles (09/2015 - 07/2002)
2.	Welling, D Bradley: 11 articles (02/2012 - 09/2002)
3.	Neff, Brian A: 10 articles (02/2015 - 09/2002)
4.	Chang, Long-Sheng: 10 articles (02/2012 - 09/2002)
5.	Lassaletta, Luis: 9 articles (09/2013 - 10/2007)
6.	Sanna, Mario: 8 articles (04/2015 - 06/2004)
7.	Driscoll, Colin L W: 8 articles (02/2015 - 07/2002)
8.	Link, Michael J: 8 articles (02/2015 - 07/2002)
9.	Plotkin, Scott R: 8 articles (06/2014 - 10/2005)
10.	Brackmann, Derald E: 8 articles (01/2014 - 05/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acoustic Neuroma:

1.	GadoliniumIBA 12/01/1991 - "The early diagnosis of acoustic neuromas with the use of gadolinium-enhanced MRI may lead to better outcome following surgery. " 10/01/1998 - "Fast spin echo magnetic resonance imaging techniques without gadolinium have been shown to be as effective in the detection of acoustic neuroma as contrast-enhanced magnetic resonance imaging. " 03/01/2000 - "Gadolinium enhanced MRI is the gold standard investigation for the detection of acoustic neuroma. " 09/01/1999 - "The improved cost-effectiveness of gadolinium-enhanced magnetic resonance imaging (MRIg) as a diagnostic tool for vestibular schwannoma has resulted in smaller tumours being diagnosed. " 07/01/1994 - "Gadolinium-enhanced magnetic resonance imaging (MRI) is currently the gold standard for diagnosis of an acoustic neuroma. "
2.	Gadolinium DTPA (Magnevist)FDA Link 03/01/1999 - "The purpose of this work was to assess the changes of signal intensity on constructive interference in steady state (CISS) 3D Fourier transformation (3DFT) MRI after administration of Gd-DTPA and to evaluate the efficacy of contrast-enhanced CISS-3DFT MRI to depict the seventh and eighth cranial nerves affected by vestibular schwannomas. " 11/01/1994 - "The current gold standard for diagnosing vestibular schwannomas is MRI with gadolinium-DTPA enhancement. " 08/01/1989 - "The use of Gd-DTPA improved the quality of the MR images by markedly enhancing the acoustic tumors in all cases. " 01/01/1988 - "Clinical advantages of Gd-DTPA include shorter scan times, macroscopic tumour/oedema separation and improved detection of certain tumours, particularly acoustic neuromas." 01/01/1992 - "The fate of tumour rests following removal of acoustic neuromas: an MRI Gd-DTPA study."
3.	bevacizumab FDA Link 01/01/2010 - "We report 2 cases in which treatment with bevacizumab (for 3 months in one case and 6 months in the other) induced regression of progressive vestibular schwannomas by more than 40% and substantially improved hearing in the patient treated for 6 months. " 01/01/2010 - "Bevacizumab therapy may thus provide an effective treatment for progressive vestibular schwannomas in patients with NF2." 08/01/2012 - "Tertiary referral center Thirty-one consecutive NF2 patients who received bevacizumab for progressive vestibular schwannomas. " 06/01/2012 - "Intravenous administration of Bevacizumab (Avastin, Genetech Pharmaceuticals) has been shown to be active in the treatment of vestibular schwannomas. " 01/01/2012 - "The presented cases support the use of bevacizumab to treat vestibular schwannomas. "
4.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/01/2011 - "An inhibitor of VEGF synthesis, PTC299, is currently in Phase II trials as a potential agent to treat vestibular schwannoma. " 11/01/2008 - "Further studies are necessary to determine the role of VEGF and other molecular pathways in the growth of vestibular schwannomas and the application of anti-VEGF therapy as a potential treatment option in the future." 07/01/2015 - "In addition, the increased expression of VEGF in vestibular schwannoma compared with that in normal vestibular nerve tissue, suggests that this factor may induce neoplastic growth via the promotion of angiogenesis. " 01/01/2015 - "Interplay between VEGF-A and cMET signaling in human vestibular schwannomas and schwann cells." 01/01/2012 - "The VEGF/VEGF-R axis in sporadic vestibular schwannomas correlates with irradiation and disease recurrence."
5.	Nimodipine (Modus)FDA LinkGeneric 07/01/2014 - "Neuroprotective efficacy of prophylactic enteral and parenteral nimodipine treatment in vestibular schwannoma surgery: a comparative study." 07/01/2012 - "Animal tests, retro- and prospective clinical trials in neurosurgical departments have shown a beneficial effect of nimodipine on the preservation and recovery of facial and acoustic nerve function following vestibular schwannoma surgery. " 05/01/2012 - "Clinical trials revealed also a beneficial effect of prophylactic nimodipine treatment on cranial nerve functions following vestibular schwannoma surgery. " 12/01/2002 - "The results of the present study indicate that nimodipine may become an intra- and post-operative important adjunct to raise the rate of hearing preservation in vestibular schwannoma excision or other cerebellopontine angle surgical interventions." 12/01/2014 - "Nimodipine for peripheral nerve recovery after maxillofacial and vestibular schwannoma surgery."
6.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2011 - "Efficacy of corticosteroids in hearing preservation after radiosurgery for vestibular schwannoma: a prospective study." 05/01/2003 - "The efficacy of corticosteroids in restoring hearing in patients undergoing conservative management of acoustic neuromas." 01/01/2015 - "Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo." 05/01/2003 - "To evaluate the role of corticosteroids in restoring hearing in patients undergoing conservative management of acoustic neuromas. " 05/01/1999 - "A retrospective review of 169 patients who underwent acoustic neuroma surgery with (n = 75) or without (n = 94) a single dose of intraoperative corticosteroids was performed. "
7.	Protons (Proton)IBA 02/01/2002 - "This study evaluated proton beam irradiation in patients with acoustic neuroma. " 03/15/2011 - "Early experience using proton therapy for vestibular schwannoma treatment demonstrated local control rates of 84-100% but disappointing hearing preservation rates of 33-42%. " 02/01/2009 - "For those patients harboring large acoustic neuromas that are inoperable, hypofractionated stereotactic proton beam offers long-term control with minimal side-effects." 02/01/2009 - "A retrospective study evaluating the role of hypofractionated stereotactic proton beam therapy for acoustic neuromas. " 09/01/2002 - "Proton beam stereotactic radiosurgery of vestibular schwannomas."
8.	Cerebrospinal fluid leakIBA 11/01/2005 - "The purpose of the study was to identify specific aspects of surgical approach design and closure technique aimed at reducing the incidence of cerebrospinal fluid leak after cerebellopontine angle tumor surgery. " 02/01/2015 - "Are there modifiable risk factors to prevent a cerebrospinal fluid leak following vestibular schwannoma surgery?" 10/01/2012 - "Dural defect repair in translabyrinthine acoustic neuroma surgery and its implications in cerebrospinal fluid leak occurrence." 04/01/2010 - "Prevention of cerebrospinal fluid leak after translabyrinthine resection of vestibular schwannoma." 04/01/2008 - "Cerebrospinal fluid leak after retrosigmoid excision of vestibular schwannomas."
9.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 03/01/1995 - "The authors retrospectively reviewed the charts of 492 patients who underwent acoustic neuroma surgery to determine the efficacy of fibrin glue in preventing postoperative CSF leak. " 03/01/2009 - "The objectives of this study were to evaluate outcomes from facial nerve (FN) cable grafting in patients who experienced FN transection during vestibular schwannoma removal and to compare the FN outcomes of patients who underwent FN grafting by using fibrin glue with those of patients who underwent FN grafting by using microsuture. " 01/01/1998 - "Following removal of the acoustic neurinoma, the drilled posterior wall of the internal auditory canal is covered with bonewax, muscle or fat pieces, and fibrin-glue, while the previously reflected dura is sutured in place keeping the packing material in position. " 03/01/1995 - "No decrease was noted in the incidence of CSF leak following acoustic neuroma surgery with the use of autologous fibrin glue." 03/01/2015 - "To evaluate the results of facial nerve (FN) grafting using great auricular cable graft and fibrin glue without suturing to palliate FN disruption after removal of large cerebellopontine angle (CPA) vestibular schwannoma (VS) or facial nerve schwannoma (FNS). "
10.	lapatinib (GW572016)FDA Link 08/01/2010 - "ErbB/HER receptor activation and preclinical efficacy of lapatinib in vestibular schwannoma." 09/01/2012 - "This single-institution phase II study was performed to estimate the response rate to lapatinib in neurofibromatosis type 2 (NF2) patients with progressive vestibular schwannoma (VS). " 09/01/2012 - "Phase II trial of lapatinib in adult and pediatric patients with neurofibromatosis type 2 and progressive vestibular schwannomas." 07/01/2011 - "ErbB expression, activation, and inhibition with lapatinib and tyrphostin (AG825) in human vestibular schwannomas."

Therapies and Procedures

1.	Radiotherapy 05/01/1991 - "The high incidence of acoustic tumors with no detectable growth or apparent spontaneous regression must be taken into account when evaluating the indications for surgery and the efficacy of radiotherapy.(ABSTRACT TRUNCATED AT 250 WORDS)" 08/01/2015 - "Although there is abundant evidence regarding the efficacy of radiotherapy for acoustic schwannoma, the value of radiotherapy as a treatment alternative for patients with ECNHS, especially those unsuitable for surgery, has not been established and further studies are warranted." 01/01/2014 - "Randomised controlled trials (RCTs) exploring the efficacy of stereotactic radiotherapy compared with observation alone, microsurgical resection or any other possible treatment or combination of treatments in patients with a cerebellopontine angle tumour up to 3 cm in diameter, presumed to be a vestibular schwannoma. " 02/01/2013 - "To evaluate long-term outcomes and efficacy of fractionated stereotactic radiotherapy in the treatment of acoustic neuromas. " 01/01/2008 - "Safety and efficacy of fractionated stereotactic radiotherapy for acoustic neuromas."
2.	Endoscopes 08/01/2008 - "To explore the therapeutic efficacy and complications of endoscope-assisted surgical resection of acoustic neuroma. " 11/01/2013 - "The endoscope-assisted retrosigmoid keyhole approach can be considered an effective and safe method for removal of vestibular schwannoma. " 02/01/2006 - "In conclusion, endoscope-controlled removal of the intrameatal vestibular schwannomas seems to be a technically feasible, effective and safe procedure. " 01/01/2009 - "Application of endoscope assisting in retrosigmoid approach can be helpful for totally resection of vestibular schwannoma in inner acoustic meatus without lesion of canalis semicircularis and glomus jugulare. " 10/01/2010 - "Combined endoscope-assisted translabyrinthine subtemporal keyhole approach for vestibular Schwannoma and auditory midbrain implantation: Cadaveric study."
3.	Particle Accelerators 09/01/2013 - "Linear accelerator-based stereotactic radiosurgery offers a safe and effective treatment for patients with vestibular schwannoma by providing high local control rates along with improved quality of life through well-preserved hearing function." 05/01/2010 - "The aim of this study was to investigate the efficacy of linear accelerator (LINAC)-based radiosurgery in the treatment of acoustic neuromas. " 09/01/2013 - "The aim of the study is to report our 15-year single center experience using linear accelerator-based stereotactic radiosurgery in the management of patients with vestibular schwannoma. " 10/01/2015 - "To examine tumour control, via volume changes, and the complications of linear accelerator (LINAC)-based stereotactic radiosurgery (SRS) treatment of vestibular schwannomas (VSs) on medium-term follow-up. " 02/01/2015 - "Long-term follow-up results of linear accelerator-based radiosurgery for vestibular schwannoma using serial three-dimensional spoiled gradient-echo MRI."
4.	Decompression 01/01/2011 - "The retromastoid approach has been effective in exposing the cerebellopontine angle for resection of a variety of lesions, including vestibular schwannomas and decompression of cranial nerves. " 04/01/2015 - "A fully endoscopic retrosigmoid approach is a safe and effective procedure for cerebellopontine angle tumor resection and cranial nerve microvascular decompression. " 05/01/2015 - "Monitoring of the intraoperative auditory brainstem response (ABR) is a less invasive, easy, and useful method for hearing preservation in patient undergoing cerebellopontine angle surgery such as microvascular decompression (MVD) and excision of an acoustic neurinoma. " 04/01/2015 - "Cerebellopontine angle tumor resection and cranial nerve microvascular decompression are usually performed with the aid of the surgical microscope. " 12/01/2014 - "The retrosigmoid endoscopic approach for cerebellopontine-angle tumors and microvascular decompression."
5.	Cochlear Implantation 12/01/2008 - "Cochlear implantation at the time of acoustic neuroma removal with VIII nerve sparing can be a safe and effective hearing restoration procedure." 09/01/2013 - "This is a retrospective multicentre study investigating outcomes of cochlear implantation in profoundly deaf patients with vestibular schwannoma in the implanted ear. " 07/01/2015 - "The indication criteria for cochlear implantation have been changed over the years and the growing number of implantations in patients after acoustic neuroma resections underline the importance of a postoperative MR imaging to assess the internal auditory canal (IAC) and the labyrinth. " 10/01/2014 - "Both control patients had incidentally detected acoustic neuromas, which altered the side of the cochlear implantation. " 01/01/2014 - "Removal of vestibular schwannoma (VS) with preservation of the cochlear nerve and cochlear implantation. "