Neuroma

05/01/1996 - "A single corticosteroid injection cannot be recommended as a cure for symptoms of third webspace neuroma, but it can be offered as a temporizing measure or as nonoperative treatment. "
09/01/2012 - "Efficacy of corticosteroid injection versus size of plantar interdigital neuroma."
01/01/2018 - "This study found that, with a cut-off value of 6.3 mm, larger Morton's neuromas were associated with failure of corticosteroid injection."
06/01/2021 - "Corticosteroid Injection for Morton's Interdigital Neuroma: A Systematic Review."
04/01/2021 - "Forty-five neuromas in 36 patients were injected with a single corticosteroid injection either with or without ultrasound guidance. "

01/01/2005 - "Results of morphometric analysis revealed that Px procedure caused an elevation of collagen content of the sciatic nerve and macroscopic neuroma formation, and that there was a statistically significant reduction in collagen content of the same region in pinealectomized animals treated with MLT (p<0.001). "
09/01/2010 - "Our findings indicate that collagen conduit is an effective treatment for post-traumatic painful neuromas of digital nerves and common digital nerves."
07/01/2010 - "This study histologically compared the incidence of neuroma formation, connective tissue proliferation, and axonal regrowth in transected rat sciatic nerves repaired with and without tubular collagen nerve sleeves. "
01/01/2007 - "This study examined the use of biosynthetic collagen nerve guides to prevent the development of posttraumatic neuromas. "
12/01/2021 - "Aligned nanofiber nerve conduits inhibit alpha smooth muscle actin expression and collagen proliferation by suppressing TGF-β1/SMAD signaling in traumatic neuromas."

11/13/2019 - "Tinel's sign, local anesthetic injection, MRI and ultrasound could help the diagnosis and identify the precise location of neuroma. "
11/01/2006 - "Although there was no apparent neuroma formation on her neck, MRI findings are inconclusive and she had not responded to injection of local anesthetics at all."
02/01/1998 - "Sonography was performed when clinical findings supplemented by local anesthetic block did not conclusively confirm the presence of recurrent neuroma. "
04/01/1998 - "To determine the outcome of surgical excision of Morton's neuroma after a local anesthetic diagnostic block into the neuroma has relieved symptoms. "
10/01/2021 - "Symptomatic neuromas were determined based on neuropathic pain characteristics, the presence of Tinel's sign or tenderness, and response to local anesthetic injection. "

07/01/1996 - "Radioimmunoassay confirmed a significantly greater density of sodium channels in the neuromas as compared with the sural nerves. "
12/01/2008 - "We demonstrate upregulation of sodium channel Nav1.3, as well as Nav1.7 and Nav1.8, in blind-ending axons within human painful neuromas. "
05/01/2007 - "The results demonstrated that sodium channel Na(v)1.7 was expressed in human lingual nerve neuromas. "
05/01/2007 - "Na(v)1.7 sodium channel expression in human lingual nerve neuromas."
08/01/2002 - "Both subtypes of sodium channels PN1 and PN3 accumulated abnormally in human neuromas. "

01/01/2023 - "Eligible patients with neuromas were identified based on blocks using anesthetic. "
05/01/2019 - "Preoperative anesthetic injection may help identify patients that benefit from neuroma surgery. "
06/01/2017 - "In flap elevation involving the sensitive superficial nerve, the local nerve was always sacrificed to obtain an anesthetic donor site; however, such a procedure introduced the possibility of painful neuromas. "
05/01/1998 - "In the lower extremity, this requires identification of the appropriate nerves by anesthetic block, resection of the dorsal foot neuroma(s), and translocation of the nerves into the muscles of the anterolateral compartment. "
01/01/1986 - "Mechanically tapping the neuroma elicited repetitive discharges at 4 to 5 Hz in the intrinsic muscles of the hand; these discharges were abolished by anesthetic block proximal to the neuroma. "

11/01/2022 - "Tender Nasal Traumatic (TNT) Neuroma: Case Report and Review."
02/01/2008 - "In the tibial neuroma transposition (TNT) model, the posterior tibial nerve was ligated and transected in the foot just proximal to the plantar bifurcation. "
02/01/2023 - "Histology and qRT-PCR showed that TMEM63A was mainly expressed in mechanical pain-producing non-peptidergic nociceptors in the DRG, and the expression of TMEM63A increased significantly both in the neuroma from amputated patients and the DRG in a mouse model of tibial nerve transfer (TNT). "
01/06/2023 - "The tibial neuroma transposition (TNT) is a rat model in which allodynia at the neuroma site (tibial nerve) can be independently evaluated from allodynia at the plantar surface of the hind paw innervated by the intact sural nerve. "
12/01/2022 - "We used a tibial neuroma transposition (TNT) rat model to mimic neuroma pain. "

11/01/2022 - "Targeted muscle reinnervation (TMR) has emerged as a useful solution to the problem of painful neuromas and is increasingly being applied in many clinical circumstances. "
01/01/1998 - "Reliable prevention of neuroma is a problem the solution of which is still outstanding. "
09/23/1988 - "The 5-week-old neuromas were desheathed, placed in a perspex chamber, in situ, and superfused with Tyrode solution. "
08/01/1985 - "As an alternative surgical solution, the neuroma may be resected and the proximal end buried within the substance of the brachialis muscle."
12/01/2022 - "Hence, our study suggests that selective neuroma denervation may be an effective solution to improve the quality of life of patients who develop this complication after TKA."

10/01/2006 - "Possibilities include reduction of ectopic neuroma activity, shielding from possible electromagnetic weather impulses (sferics), or analgesic effects of changes in the electromagnetic field. "
01/01/2023 - "End-neuroma treatment with excision and capping resulted in long-term significant reduction in reported pain, disability, and analgesic medication use. "
01/01/2023 - "Main outcome measures were pain, function, recurrence of symptomatic neuroma, use of analgesics, and adverse events. "
01/01/2019 - "Information obtained included neuroma size and nerve, RFA duration/temperature, pain scores, analgesic requirements and ease/comfort of prosthetic use. "
07/01/2015 - "Conclusion Differential analgesic effects of subanesthetic concentrations of local lidocaineon evoked and spontaneous pain in human neuroma suggest that different mechanisms underlie these two key clinical symptoms. "

01/01/1997 - "Local blood flow in older experimental neuromas at 7 days had partial sensitivity to morphine, whereas at 14 days perfusion flow was not influenced by morphine. "
12/04/1989 - "The basal release was demonstrated by exposing the neuromas, in situ, to solutions containing 50 microM morphine plus 2 mM CoCl2 for 24 h.(ABSTRACT TRUNCATED AT 250 WORDS)"
09/01/2009 - "A neuroma was found on the left second common digital nerve and was removed, but his symptoms continued despite various conservative treatments including a morphine infusion pump on his left arm. "
01/01/1997 - "Systemic morphine reversed hyperemia by vasoconstricting both extrinsic and intrinsic microvessels supplying 48-h-old "neuroma" preparations or crush zones of peripheral nerve trunks. "
07/01/2012 - "Morphine was less potent in neuroma pain than in mechanical allodynia. "

02/01/2022 - " Identifying patients at risk for prolonged opioid use following surgery for symptomatic neuroma would be beneficial for perioperative management. "
02/01/2022 - "The aim of this study is to identify the factors associated with postoperative opioid use of >4 weeks in patients undergoing neuroma surgery. "
02/01/2022 - "Long-Term Opioid Use Following Surgery for Symptomatic Neuroma."
03/01/2020 - "Symptomatic neuromas and pain caused by nerve transection injuries can adversely impact a patient's recovery, while also contributing to increased dependence on opioid and other pharmacotherapy. "
01/01/2017 - "There was higher prevalence of PLP and PLS among the patients with history of preamputation pain, smoking with proximal level of amputation, receiving general anesthesia, receiving intravenous (IV) opioid postoperative analgesia, and developing neuroma or infection. "

01/01/1995 - "This significantly improved hand function and contour and alleviated a painful neuroma at the former ring finger amputation site. "
01/01/2021 - "Targeted muscle reinnervation (TMR) and regenerative peripheral nerve interface (RPNI) procedures have been shown to improve patient-reported outcomes for the treatment of symptomatic neuromas after amputation; however, the specific indications and comparative outcomes of each are unclear. "
07/01/2014 - "Key words:Amputation neuroma, traumatic neuroma, mandible, spontaneous remission. "
08/24/2023 - "This study suggested that RPNI can effectively prevent the formation of symptomatic neuroma after amputation using ultrasound."
01/01/2022 - "These findings suggest that neuroma after amputation might be underestimated in studies with a short duration of follow-up."

11/01/2021 - "The sequelae of neuromas-in-continuity of the SPN, deep peroneal nerve, and sural nerves were noted to have significantly improved with proximal neurectomy and subsequent bridging utilizing a nerve allograft and conduit construct. "
12/01/2015 - "Both simple neurectomy and neurectomy with intramuscular implantation demonstrated significant improvement in terms of functional outcomes as measured with the FFI, SF-36, and VAS in patients with interdigital neuroma. "
12/01/2022 - "Recurrent symptoms after neurectomy can be due to a recurrent interdigital neuroma. "
12/01/2022 - "Patient reported outcomes following revision neurectomy through a dorsal approach for recurrent interdigital neuroma."
10/01/2022 - "Patients with a neuroma ( n = 43) were most satisfied after proximal denervation with burying into the brachioradialis muscle compared with burying elsewhere (53 versus 0 percent; p < 0.001). "

08/01/2014 - "The study findings imply that ESWT for stump neuroma is superior to conventional therapy."
06/01/2011 - "Alcohol sclerosing therapy is not an effective treatment for interdigital neuroma."
06/01/2011 - "Alcohol sclerosing therapy has been reported as a safe and effective means of treating interdigital neuromas, both with or without ultrasound. "
03/01/2004 - "The aim of our study was to evaluate the efficacy of neuroma alcohol-sclerosing therapy (NAST) under US guide in MN after a 10-month follow-up. "
01/01/2023 - "Seventeen studies were included, with twelve prognostic studies of the effect of time on CI, four studies of self management/behavioural therapies, and a single study of surgical treatment of neuromas. "

01/01/2022 - "The aim of this study was to determine the most cost-effective treatment pathway for symptomatic Morton neuromas when conservative management has failed. "
07/01/2023 - "Following failed conservative management, the patient underwent excision of the neuroma. "
05/07/2021 - "Neuroma management ranges from conservative therapy to surgery with varying success rates. "
08/01/2018 - "Conservative treatment is feasible in properly selected cases with asymptomatic neuromas after an accurate tissue sampling. "
05/01/2016 - "In contrast to standard conservative management, this cohort underwent exploration, C5-6 neuroma excision, and sural nerve grafting. "

01/01/2021 - "Targeted Muscle Reinnervation: A Paradigm Shift for Neuroma Management and Improved Prosthesis Control in Major Limb Amputees."
04/26/2023 - "Neuroma symptoms occurred less frequently and functional and prosthesis control outcomes improved following TMR. "
01/01/2021 - "In tandem with advances in myoelectric prosthetics, TMR surgery provides amputees with improved control of myoelectric prostheses and simultaneously prevents or treats painful neuromas. "
06/01/2019 - "Targeted muscle reinnervation (TMR) is a surgical technique that improves modern myoelectric prosthesis functionality and plays an important role in the prevention and treatment of painful postamputation neuromas. "
01/01/2018 - "Targeted muscle reinnervation is an evolving technique that improves control of myoelectric prostheses and can prevent or treat symptomatic neuromas. "