Neuroma

01/01/2005 - "Results of morphometric analysis revealed that Px procedure caused an elevation of collagen content of the sciatic nerve and macroscopic neuroma formation, and that there was a statistically significant reduction in collagen content of the same region in pinealectomized animals treated with MLT (p<0.001). "
09/01/2010 - "Our findings indicate that collagen conduit is an effective treatment for post-traumatic painful neuromas of digital nerves and common digital nerves."
07/01/2010 - "This study histologically compared the incidence of neuroma formation, connective tissue proliferation, and axonal regrowth in transected rat sciatic nerves repaired with and without tubular collagen nerve sleeves. "
01/01/2007 - "This study examined the use of biosynthetic collagen nerve guides to prevent the development of posttraumatic neuromas. "
07/01/2013 - "Collagen conduits were safe and generally successful adjuncts to simple excision in the management of painful neuromas of the foot and ankle. "

07/01/1996 - "Radioimmunoassay confirmed a significantly greater density of sodium channels in the neuromas as compared with the sural nerves. "
12/01/2008 - "We demonstrate upregulation of sodium channel Nav1.3, as well as Nav1.7 and Nav1.8, in blind-ending axons within human painful neuromas. "
12/01/2008 - "Because sodium channels are known to play critical roles in neuronal electrogenesis and hyperexcitability, we examined the expression of all the neuronal voltage-gated sodium channels (Nav1.1, Nav1.2, Nav1.3, Nav1.6, Nav1.7, Nav1.8, and Nav1.9) within human painful neuromas. "
05/01/2007 - "The results demonstrated that sodium channel Na(v)1.7 was expressed in human lingual nerve neuromas. "
05/01/2007 - "Na(v)1.7 sodium channel expression in human lingual nerve neuromas."

01/01/1997 - "Local blood flow in older experimental neuromas at 7 days had partial sensitivity to morphine, whereas at 14 days perfusion flow was not influenced by morphine. "
12/04/1989 - "The basal release was demonstrated by exposing the neuromas, in situ, to solutions containing 50 microM morphine plus 2 mM CoCl2 for 24 h.(ABSTRACT TRUNCATED AT 250 WORDS)"
09/01/2009 - "A neuroma was found on the left second common digital nerve and was removed, but his symptoms continued despite various conservative treatments including a morphine infusion pump on his left arm. "
01/01/1997 - "Systemic morphine reversed hyperemia by vasoconstricting both extrinsic and intrinsic microvessels supplying 48-h-old "neuroma" preparations or crush zones of peripheral nerve trunks. "
07/01/2012 - "Morphine was less potent in neuroma pain than in mechanical allodynia. "

06/01/2011 - "We report a series of patients with interdigital neuroma treated using ethanol sclerosing therapy in a clinic setting without the use of ultrasound. "
11/01/2014 - "The lack of any measureable changes in nerve or adjacent muscle histology with ethanol injection into the rat sciatic nerve (and surrounding tissues) raises questions about the efficacy of using ethanol injections in the treatment of Morton's neuroma in human clinical practice."
06/01/2011 - "We retrospectively reviewed charts of 32 consecutive patients who were enrolled to receive a series of sclerosing ethanol injections from June 2009 to April 2010 for the treatment of a painful interdigital neuroma. "
05/01/2011 - "Our studies using various experimental injury models clearly suggest positive effects of MLT on the number of axons, thickness of myelin sheath by inhibition of collagen accumulation and neuroma formation following traumatic events to peripheral nerves, myelination of developing peripheral nerve after intrauterine ethanol exposure. "
03/01/2005 - "Proximal nerve resection was followed by Mersiline (Ethicon, Inc., Somerville, NJ) ligature and absolute alcohol or phenol application to prevent neuromas. "

07/01/2012 - "Morphine-but not pregabalin, gabapentin, and duloxetine-attenuated the neuroma pain. "
07/01/2012 - "In the 2-drug-combination studies (morphine + pregabalin, morphine + duloxetine, and pregabalin + duloxetine), all drug combinations produced a synergistic effect on mechanical allodynia, but not on neuroma pain. "
07/01/2012 - "These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain."
07/01/2012 - "The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model."
07/01/2012 - "We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model. "

07/01/2012 - "Morphine-but not pregabalin, gabapentin, and duloxetine-attenuated the neuroma pain. "
07/01/2012 - "In the 2-drug-combination studies (morphine + pregabalin, morphine + duloxetine, and pregabalin + duloxetine), all drug combinations produced a synergistic effect on mechanical allodynia, but not on neuroma pain. "
07/01/2012 - "These data indicate that the potency of morphine and the efficacy of pregabalin, gabapentin, and duloxetine on mechanical allodynia are different from those on neuroma pain and that combination therapy is one of different therapeutic choices for the treatment of neuropathic pain."
07/01/2012 - "The efficacy of morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model."
07/01/2012 - "We compared the efficacy of orally administered morphine, pregabalin, gabapentin, and duloxetine on mechanical allodynia with that on neuroma pain using the tibial neuroma transposition (TNT) model. "

12/01/2006 - "NGF levels suggest an explanation for the development of painful neuromas and the efficacy of relocation."
07/01/2001 - "Nerve growth factor inhibition prevents traumatic neuroma formation in the rat."
05/27/1997 - "NGF immunostaining was observed in Schwann cells in distal nerve segments with pockets of high levels in some neuromas. "
07/01/1996 - "The NGF group formed thick axonal bundles and abundant neuroma. "
03/29/1996 - "In injured nerves, NGF levels were reduced when compared to intact nerve, except acutely distal to injury; NGF-immunostaining was seen in Schwann cells in distal segments, including neuromas. "

10/01/1993 - "Fifteen patients with clinically suspected Morton neuroma underwent examination with conventional T1- and T2-weighted MR imaging and a combination of fat suppression and administration of gadopentetate dimeglumine. "
05/01/1989 - "This may provide greater access for contrast material into relatively larger extracellular spaces in neuromas and may cause a greater T1 relaxation rate increment with Gd-DTPA.(ABSTRACT TRUNCATED AT 250 WORDS)"
07/01/1992 - "However, the signal enhancement at the vascular phase, ie, the phase where the first passage of Gd-DTPA was recognized both in the arteries and veins, was approximately four times as high in meningiomas as in neuromas. "
07/01/1992 - "Eleven patients with neuromas and 15 patients with meningiomas underwent dynamic contrast-enhanced MR imaging using a short TE FLASH sequence and a bolus injection of Gd-DTPA. "
06/01/1989 - "Seven glomus tumours, one facial neuroma and one carcinoid tumor received intravenous gadolinium DTPA. "

02/01/2011 - "In conclusion the Hyperventilation Test can provide patterns of oculomotor responses that indicate a diagnostic investigation through cerebral magnetic resonance imaging enhanced by gadolinium, upon suspicion of neuroma of the 8(th) cranial nerve or of a central disease. "
11/01/1998 - "[From 8th cranial nerve neuroma to vestibular schwannoma without using gadolinium? "
07/01/1998 - "Gadolinium-enhanced magnetic resonance imaging in the axial and coronal planes can help identify cochlear neuromas in selected patients with unilateral sensorineural hearing loss."
01/01/1997 - "MR scans with gadolinium were sometimes helpful when the differential diagnosis included synovitis, Morton's neuroma or intramuscular myxoma, and when it was important to differentiate cystic from solid lesions. "
02/01/1991 - "Ten patients with surgically confirmed residual cerebellopontine angle neuromas, imaged by both computerized tomography (CT) with iodine contrast and magnetic resonance (MR) with and without gadolinium enhancement, are reviewed to identify the strengths and limitations of MR as compared with CT imaging. "

02/01/2008 - "In the tibial neuroma transposition (TNT) model, the posterior tibial nerve was ligated and transected in the foot just proximal to the plantar bifurcation. "
07/01/2012 - "After TNT injury, mechanical allodynia and neuroma pain are observed. "
02/01/2008 - "The TNT model provides a useful tool to investigate the differential mechanisms underlying the neuroma tenderness and mechanical hyperalgesia associated with neuropathic pain."
02/01/2008 - "The tibial neuroma transposition (TNT) model of neuroma pain and hyperalgesia."
06/01/2015 - "Neuropathic pain (mechanical allodynia and neuroma pain) is observed after TNT injury. "

01/01/2010 - "Autologous nerve grafts are the "gold standard" for superior regenerative capability, but are limited by the length and potential neuroma formation at the donor site. "
07/01/1997 - "This study analyzed the efficacy of an interposed vein conduit graft in eliminating symptoms of painful neuroma of sensory nerves of the hand and preventing recurrence after excising the pathologic tissue and bridging the concomitant gap with the distal nerve segment. "
02/01/2012 - "The gold standard of treatment for peripheral nerve gaps >5 mm is the autologous nerve graft; however, this treatment is associated with a variety of clinical complications, such as donor site morbidity, limited availability, nerve site mismatch, and the formation of neuromas. "
06/01/2008 - "To study the use of a nerve ''bypass'' graft as a possible alternative to neurolysis or segmental resection with interposition grafting in the treatment of neuroma-in-continuity. "
09/01/1985 - "[The lyophilized homologous nerve graft for the prevention of neuroma formation (animal experiment study)]."

01/01/1995 - "This significantly improved hand function and contour and alleviated a painful neuroma at the former ring finger amputation site. "
07/01/2014 - "Key words:Amputation neuroma, traumatic neuroma, mandible, spontaneous remission. "
03/01/1982 - "The results of a light and electron microscopy study of seven amputation neuromas are presented. "
03/01/1982 - "[Histopathologic and ultrastructural study of various amputation neuromas]."
09/01/1980 - "An experimental study was conducted in dogs and the results confirmed the presence, at the upper extremity, of both an amputation neuroma and neuronal changes, though these latter lesions were limited to a region 3 cm above the section level. "

03/01/1990 - "Experimental studies have shown that laser-assisted nerve coaptation are equal if not superior to conventional techniques in the reduced incidence of neuroma formation as well as the regenerative capacity. "
01/01/1985 - "Clinical observation and follow-up of horses subjected to laser neurectomy tend to support the reported concept that the laser is superior to conventional instruments for prevention of painful neuroma in peripheral nerves."
01/01/1996 - "The purpose of this study was to determine whether the milliwatt laser can suppress neuroma formation at the end of a divided nerve. "
05/01/1984 - "If sealed nerve ends are the desired effect, such as in treatment of painful neuromas, this experimental animal study in rats suggests that the laser may be contraindicated because of the possible retention of proximal nerve regenerative ability. "
04/01/2008 - "Grossly, laser-transected nerves showed an infrequent incidence of neuroma formation. "

07/01/2005 - "The purpose of this investigation was to conduct a prospective trial to assess the effectiveness of a 4% sclerosing alcohol injection in a small group of patients with intermetatarsal neuromas who had failed previous conservative therapies including corticosteroid injections. "
11/01/2001 - "This study aimed to evaluate the neuroma's intralesional treatment with alcohol sclerosing injection as a viable alternative to steroid injections or surgery in persisting symptoms. "
11/01/1999 - "In this study, 100 adult patients with previously untreated intermetatarsal neuromas received three to seven injections of a 4% alcohol sclerosing solution every 5-10 days. "
05/01/1996 - "The object of the study was to determine if needle-free injections with the Biojector were equivalent to needle and syringe injections for ankle, Mayo, neuroma, hallux, and digital anesthetic blocks. "
01/01/2015 - "A mean number of 3.0 (range, 1 to 4) injections were performed for each neuroma. "

09/01/1976 - "A technique of funicular resection with epineurial ligation in 45 patients with neuromas achieved about the same percentage of good results as did simple excisional neurectomy. "
08/01/1987 - "Fascicular ligation in the prevention and treatment of painful terminal neuroma: an experimental study in the rat."
08/01/2011 - "We demonstrate increased levels of Na(V)1.7 in experimental rat sciatic nerve neuromas, 2weeks after nerve ligation and transaction. "
09/01/2008 - "Chemical methods, and microsurgical techniques including fascicular ligation, and burying into muscle and bone have been reported to prevent neuroma-in-continuity formation. "
02/01/1998 - "There was no significant difference between the levels of spontaneous activity or mechanical sensitivity in the two groups or that previously found in ligature-induced neuromas. "