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Neuroleptic Malignant Syndrome

A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
Also Known As:
NMS (Neuroleptic Malignant Syndrome); NMSs (Neuroleptic Malignant Syndrome); Neuroleptic Induced Neuroleptic Malignant Syndrome; Neuroleptic Malignant Syndrome, Neuroleptic Induced; Neuroleptic Malignant Syndromes; Syndrome, Neuroleptic Malignant; Syndromes, Neuroleptic Malignant; Neuroleptic-Induced Neuroleptic Malignant Syndrome; Neuroleptic-Malignant Syndrome, Neuroleptic Induced
Networked: 1438 relevant articles (37 outcomes, 26 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Tardive Dyskinesia
2. Parkinson Disease (Parkinson's Disease)
3. Fever (Fevers)
4. Malignant Hyperthermia
5. Catatonia

Experts

1. Kawanishi, Chiaki: 9 articles (09/2020 - 01/2003)
2. Caroff, Stanley N: 8 articles (05/2020 - 11/2002)
3. Correll, Christoph U: 7 articles (10/2021 - 02/2012)
4. Kane, John M: 6 articles (10/2021 - 02/2012)
5. Kishida, Ikuko: 6 articles (11/2007 - 03/2003)
6. Misawa, Fuminari: 5 articles (10/2021 - 02/2013)
7. Nisijima, Koichi: 5 articles (12/2015 - 01/2007)
8. Tanii, Hisashi: 5 articles (01/2012 - 03/2006)
9. Bourgeois, James A: 5 articles (03/2009 - 01/2002)
10. Hirayasu, Yoshio: 5 articles (11/2007 - 03/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neuroleptic Malignant Syndrome:
1. Dantrolene (Dantrium)FDA LinkGeneric
2. Antipsychotic Agents (Antipsychotics)IBA
3. Bromocriptine (Parlodel)FDA LinkGeneric
4. Clozapine (Clozaril)FDA LinkGeneric
5. Diazepam (Valium)FDA LinkGeneric
6. Haloperidol (Haldol)FDA LinkGeneric
7. LithiumIBA
8. MethylprednisoloneFDA LinkGeneric
9. Olanzapine (Zyprexa)FDA Link
10. Risperidone (Risperdal Consta)FDA LinkGeneric

Therapies and Procedures

1. Therapeutics
2. Intramuscular Injections
3. Intravenous Injections
4. Injections
5. Induced Hyperthermia (Thermotherapy)