Neurodermatitis (Lichen Simplex Chronicus)

An extremely variable eczematous skin disease that is presumed to be a response to prolonged vigorous scratching, rubbing, or pinching to relieve intense pruritus. It varies in intensity, severity, course, and morphologic expression in different individuals. Neurodermatitis is believed by some to be psychogenic. The circumscribed or localized form is often referred to as lichen simplex chronicus.

Also Known As:

Networked: 258 relevant articles (16 outcomes, 22 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema)
2.	Psoriasis (Pustulosis Palmaris et Plantaris)
3.	Eczema
4.	Pruritus (Itching)
5.	Prurigo

Experts

1.	Corazza, Monica: 3 articles (08/2015 - 01/2003)
2.	Virgili, Annarosa: 3 articles (08/2015 - 01/2003)
3.	Borghi, Alessandro: 2 articles (08/2015 - 12/2014)
4.	Minghetti, Sara: 2 articles (08/2015 - 12/2014)
5.	Goldstein, Andrew T: 2 articles (09/2009 - 01/2007)
6.	Northcutt, Alan D: 1 article (10/2015)
7.	Tschen, Jaime A: 1 article (10/2015)
8.	Guerrero, Angela: 1 article (09/2015)
9.	Venkatesan, Aruna: 1 article (09/2015)
10.	Toni, Giulia: 1 article (08/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurodermatitis:

1.	Urea (Carbamide)FDA LinkGeneric 01/01/1992 - "[Long-term study "Neurodermatitis therapy using urea-containing Externa". " 01/01/1992 - "[Long-term study "Neurodermatitis therapy using urea-containing Externa". " 01/01/1992 - "[Long-term study "Neurodermatitis therapy using urea-containing Externa"]." 01/01/1992 - "In addition to its special properties in the therapy of neurodermatitis, urea also ranks high as a physiological substitution." 01/01/1992 - "Thus, urea preparations can also be especially recommended for use in patients with neurodermatitis."
2.	diflucortolone valerateIBA 11/01/1989 - "Diflucortolone valerate ointment with and without occlusion in lichen simplex chronicus." 05/01/1976 - "The trial preparation, diflucortolone valerate, was tested clinically in the form of fatty ointment on 27 patients: 4 with psoriasis, 4 with neurodermatitis, 4 with contact dermatitis, 2 with actinodermatitis, 10 with eczema, 2 with cutaneous reticulosis and 1 with radiodermitis. " 12/01/1991 - "In a double-blind, parallel-group, multicenter, comparative trial in 120 evaluable patients with chronic, localized atopic dermatitis or lichen simplex chronicus, the success rate (described as "healed" and "marked improvement") was 91.5% in patients treated with halobetasol propionate ointment and 83.6% in those in the diflucortolone valerate treatment group. " 12/01/1991 - "A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus."
3.	halobetasol (ulobetasol)FDA LinkGeneric 12/01/1991 - "In a double-blind, parallel-group, multicenter, comparative trial in 120 evaluable patients with chronic, localized atopic dermatitis or lichen simplex chronicus, the success rate (described as "healed" and "marked improvement") was 91.5% in patients treated with halobetasol propionate ointment and 83.6% in those in the diflucortolone valerate treatment group. " 12/01/1991 - "A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus." 12/01/1991 - "In a double-blind, parallel-group, multicenter comparative trial in 127 evaluable patients with chronic, localized atopic dermatitis or lichen simplex chronicus, healing was reported in a higher percentage of patients treated with halobetasol propionate ointment than in those in the clobetasol propionate treatment group (65.1% versus 54.7%). " 12/01/1991 - "A double-blind, multicenter trial of 0.05% halobetasol propionate ointment and 0.05% clobetasol 17-propionate ointment in the treatment of patients with chronic, localized atopic dermatitis or lichen simplex chronicus."
4.	Tacrolimus (Prograf)FDA LinkGeneric 07/01/2015 - "Effective treatment of scrotal lichen simplex chronicus with 0.1% tacrolimus ointment: an observational study." 01/01/2007 - "Topical tacrolimus for the treatment of lichen simplex chronicus." 11/01/2005 - "[Pimecrolimus and tacrolimus for neurodermatitis]." 06/01/2005 - "[Viewpoint of the German Dermatologic Society (DDG) concerning the decision of the American Food and Drug Administration (FDA) on the use of pimecrolimus cream and tacrolimus ointment in the treatment of atopic dermatitis (neurodermatitis)]." 09/01/2009 - "We provide a comprehensive summary of existing case reports, series of cases, and open-label prospective studies concerning the use of topical pimecrolimus and tacrolimus for the treatment of anogenital lichen sclerosus, genital lichen planus, vulvar lichen simplex chronicus and related pruritic vulvar dermatoses (chronic vulvar pruritus and allergic contact dermatitis of the vulva). "
5.	pimecrolimus (Elidel)FDA Link 01/01/2007 - "Pimecrolimus cream 1% for treatment of vulvar lichen simplex chronicus: an open-label, preliminary trial." 01/01/2007 - "To evaluate efficacy and safety of pimecrolimus cream 1% twice daily for treatment of vulvar lichen simplex chronicus (LSC). " 01/01/2008 - "Pimecrolimus 1% cream seems to be an effective and safe treatment modality for pruritus in postmenopausal women with vulvar lichen simplex chronicus." 01/01/2008 - "Pimecrolimus 1% cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: a prospective non-controlled case series." 11/01/2005 - "[Pimecrolimus and tacrolimus for neurodermatitis]."
6.	Ointments (Pastes)IBA 12/01/1980 - "A 25-year follow-up study was completed on 426 patients with atopic dermatitis and neurodermatitis who were hospitalized and treated with coal tar ointments and ultraviolet light at the Mayo Clinic from 1950 through 1954. " 06/01/1962 - "[Treatment of patients with eczema and neurodermatitis with hydrocortisone ointments]." 12/01/1980 - "This study offers reassurance about the relatively small risk of skin cancer developing in patients with atopic dermatitis and neurodermatitis treated with coal tar ointments and ultraviolet light (Goeckerman regimen)." 01/01/1989 - "Though urea creams provided relief from itching in neurodermatitis, their use after treatment of eczema with fat-containing salves caused burning sensations. " 01/01/1992 - "Urea ointments and emulsions are excellently suited for the care and supportive therapy of neurodermatitis patients. "
7.	Halcinonide (Dermalog)FDA Link 08/01/1982 - "An open evaluation of halcinonide 0.1 percent in a hydrophilic vanishing cream base was conducted in one hundred patients with common steroid-responsive dermatoses, including eczema, contact dermatitis, atopic dermatitis stasis dermatitis, and neurodermatitis. " 11/01/1975 - "The clinical efficacy of halcinonide and fluocinonide creams was compared in the treatment of 392 patients with corticosteroid-responsive dermatoses, including psoriasis, and various eczematous dermatoses such as atopic dermatitis, eczematous dermatitis, and neurodermatitis. " 01/01/1977 - "Halcinonide proved to be equally as effective as betamethasone dipropionate in most and superior in some patients with psoriasis, lichen chronicus simplex, and atopic and neurodermatitis. " 01/01/1976 - "Fifty patients with symmetrical, bilateral lesions of psoriasis, eczematous dermatitis, atopic dermatitis, or neurodermatitis participated in a double-blind paired comparison study in which 0-1% halcinonide (in a cream formulation containing also neomycin and nystatin) was applied to the lesions on one side of the body and 1% hydrocortisone cream to those on the opposite side for two to three weeks. "
8.	Doxepin (Mareen)FDA LinkGeneric 12/01/1995 - "To expand on our previous findings in atopic dermatitis, the present multicenter double-blind trial was conducted to evaluate the safety and antipruritic efficacy of 5% doxepin hydrochloride cream in patients with lichen simplex chronicus (n = 136), nummular eczema (n = 87), or contact dermatitis (n = 86). "
9.	PodophyllinIBA 06/01/1951 - "Lichen simplex chronicus (Vidal) treated successfully with podophyllin." 04/01/1953 - "Topical podophyllin therapy with special reference to lichen chronicus (simplex) circumscriptus (neurodermatitis circumscriptus, lichen vidal)."
10.	Flurandrenolone (Haelan)FDA Link 09/01/1969 - "Flurandrenolone tape in the treatment of lichen simplex chronicus." 10/01/2000 - "Flurandrenolide tape is a valuable agent in the treatment of lichen simplex chronicus and in psoriasis. "

Therapies and Procedures

1.	Balneology 03/01/1984 - "[Psychotherapy and balneotherapy in the treatment of children with neurodermatitis in a specialized health resort pioneer camp]." 05/01/1951 - "[Neurodermatitis, therapy with sulphur balneotherapy at Molitg-les-Bains (France)]." 01/01/1990 - "The efficacy of balneotherapy with local mineral water was estimated in 328 patients with neurodermatitis and 42 ones with prurigo. " 01/01/1990 - "[Physio-balneotherapy of neurodermatitis in children with biliary tract diseases]." 09/01/1984 - "[Thermoregulation in adolescents with diffuse neurodermatitis and psoriasis and its changes during sulfide balneotherapy]."
2.	Cryotherapy (Therapy, Cold) 06/01/1951 - "[Efficacy of cryotherapy in neurodermatitis]." 12/01/1963 - "[REMOTE RESULTS OF CRYOTHERAPY OF FOCAL NEURODERMATITIS]." 11/01/1959 - "[Cryotherapy of chronic focal neurodermatitis]." 11/01/1959 - "[Report on the use of cryotherapy in neurodermatitis]."
3.	Hypnosis (Mesmerism) 12/01/1965 - "[The effect of combined treatment with electric sleep and hypnosis on the results of electroencephalography in patients with neurodermatitis]." 10/01/1968 - "[Dynamics of immunological indices in patients with neurodermatitis during electronarcosis, hypnosis and corticosteroid therapy]." 09/01/1963 - "[COMBINED TREATMENT OF PATIENTS SUFFERING FROM NEURODERMATITIS, ECZEMA AND OTHER DERMATOSES WITH HYPNOSIS, ELECTRIC SLEEP AND CORTICOSTEROID]." 03/01/2000 - "A wide spectrum of dermatologic disorders may be improved or cured using hypnosis as an alternative or complementary therapy, including acne excoriée, alopecia areata, atopic dermatitis, congenital ichthyosiform erythroderma, dyshidrotic dermatitis, erythromelalgia, furuncles, glossodynia, herpes simplex, hyperhidrosis, ichthyosis vulgaris, lichen planus, neurodermatitis, nummular dermatitis, postherpetic neuralgia, pruritus, psoriasis, rosacea, trichotillomania, urticaria, verruca vulgaris, and vitiligo. "
4.	Reflexotherapy 01/01/1986 - "[Electroencephalographic features and the clinical efficacy of reflexotherapy in neurodermatitis patients]." 02/01/1983 - "[Laser reflexotherapy of children with severe forms of neurodermatitis]."
5.	Injections 04/01/1946 - "Neurodermatitis improved by injections of histamine phosphate." 12/01/1946 - "Circumscribed neurodermatitis (lichen chronicus simplex); its treatment by injections of alcohol."