Neurocirculatory Asthenia

A clinical syndrome characterized by palpitation, SHORTNESS OF BREATH, labored breathing, subjective complaints of effort and discomfort, all following slight PHYSICAL EXERTION. Other symptoms may be DIZZINESS, tremulousness, SWEATING, and INSOMNIA. Neurocirculatory asthenia is most typically seen as a form of anxiety disorder.

Also Known As:

Networked: 91 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Medically Unexplained Symptoms
2.	Essential Hypertension
3.	Thyrotoxicosis
4.	Hypertension (High Blood Pressure)
5.	Irritable Bowel Syndrome (Syndrome, Irritable Bowel)

Experts

1.	Ksenofontova, I V: 1 article (12/2017)
2.	Lvova, N V: 1 article (12/2017)
3.	Tupitsyna, Y Y: 1 article (12/2017)
4.	Turova, E A: 1 article (12/2017)
5.	Uyanaeva, A I: 1 article (12/2017)
6.	Belikova, T M: 1 article (04/2013)
7.	Karpushenko, E G: 1 article (04/2013)
8.	Tegza, V Iu: 1 article (04/2013)
9.	Ukhovskiĭ, D M: 1 article (04/2013)
10.	Lu, Yu-Ying: 1 article (06/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neurocirculatory Asthenia:

1.	Diazepam (Valium)FDA LinkGeneric 06/01/1992 - "In order to compare the beta blockers bisoprolol and diazepam in the treatment of cardiac neurosis, 40 patients (16 males and 24 females, mean age: 39 +/- 11 years) were examined in a double-blind, crossover study. " 06/01/1992 - "Comparison of bisoprolol and diazepam in the treatment of cardiac neurosis." 06/01/1992 - "Both treatments were effective in reducing somatic symptoms of cardiac neurosis, but bisoprolol was significantly more effective than diazepam (p less than 0.01). " 06/01/1992 - "In conclusion, bisoprolol appeared to be as effective as diazepam in the treatment of cardiac neurosis, but with better effects on somatic symptoms and without affecting patients' psychomotor performance." 01/01/1984 - "In a Finnish general practice 120 patients with psychosomatic disorders, manifest as syndromes of tension headache, cardiac neurosis, dizziness or muscular tension, were randomly allocated to treatment over a 4-week period with either flupenthixol (1 to 2 mg per day) or diazepam (5 to 10 mg mg per day). "
2.	Bisoprolol (Concor)FDA LinkGeneric 06/01/1992 - "In order to compare the beta blockers bisoprolol and diazepam in the treatment of cardiac neurosis, 40 patients (16 males and 24 females, mean age: 39 +/- 11 years) were examined in a double-blind, crossover study. " 06/01/1992 - "Comparison of bisoprolol and diazepam in the treatment of cardiac neurosis." 06/01/1992 - "Both treatments were effective in reducing somatic symptoms of cardiac neurosis, but bisoprolol was significantly more effective than diazepam (p less than 0.01). " 06/01/1992 - "In conclusion, bisoprolol appeared to be as effective as diazepam in the treatment of cardiac neurosis, but with better effects on somatic symptoms and without affecting patients' psychomotor performance."
3.	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/01/1985 - "In 10 patients suffering from cardiac neurosis changes in plasma norepinephrine (NE) and epinephrine (E) were studied by an upright bicycle exercise and during psychological stress. " 01/01/1973 - "[Effect of a beta receptor blocker on cardiac output--studies in essential hypertension and hyperkinetic heart syndrome with reference to plasma adrenaline and noradrenaline levels]." 12/01/1981 - "Insufficient data are available to make strong inferences about sympathetic activity in cardiomyopathy, essential hypertension or pulmonary hypertension, and little or no information is available about plasma norepinephrine in ventricular fibrillation without myocardial infarction, the mitral valve prolapse syndrome, digoxin effect, syndromes associated with prolonged electrocardiographic Q-T interval and the hyperkinetic heart syndrome." 07/01/1976 - "Dopamine-beta-hydroxylase (DBH), the enzyme responsible for the biosynthesis of norepinephrine from dopamine was assayed in the blood serum of 23 normal adults, 16 patients with congestive heart failure, 19 patients with asymptomatic ischemic heart disease, 4 patients with angina pectoris at rest, 15 patients with essential hypertension, 8 patients with essential hypotension, 5 patients with neurocirculatory asthenia, and 9 normal adults before and after the exercise test. "
4.	Thiamine PyrophosphateIBA 01/01/1953 - "The cocarboxylase content of blood in normal subjects and in various diseases, especially neurocirculatory asthenia." 01/01/1953 - "Cocarboxylase content of human blood; studies with normal subjects and in neurocirculatory asthenia, thyrotoxicosis, adiposity, and some other diseases; a preliminary report."
5.	Epinephrine (Adrenaline)FDA LinkGeneric 01/01/1985 - "In 10 patients suffering from cardiac neurosis changes in plasma norepinephrine (NE) and epinephrine (E) were studied by an upright bicycle exercise and during psychological stress. " 01/01/1973 - "[Effect of a beta receptor blocker on cardiac output--studies in essential hypertension and hyperkinetic heart syndrome with reference to plasma adrenaline and noradrenaline levels]."
6.	Keto AcidsIBA 09/20/1957 - "Paper chromatographic studies of blood keto acids after a fat tolerance test in certain diseases, especially neurocirculatory asthenia."
7.	GasesIBA 09/01/1999 - "By combining capnography, during the Effort Test, with analysis of blood gases and specific electrolytes, the effort-syndrome hypothesis was further tested in the present study. "
8.	ElectrolytesIBA 09/01/1999 - "By combining capnography, during the Effort Test, with analysis of blood gases and specific electrolytes, the effort-syndrome hypothesis was further tested in the present study. "
9.	Propranolol (Inderal)FDA LinkGeneric 01/01/1991 - "In twenty two young (mean age 31.6 years) normotensive women with hyperkinetic heart syndrome (HHS) we assessed echocardiographically left ventricular (LV) function indexes before and after 40 mg of oral propranolol. " 05/01/1983 - "[Propranolol test in the differential diagnosis of post-exercise ECG changes in women with neurocirculatory asthenia]." 06/01/1979 - "Propranolol in the treatment of neurocirculatory asthenia--an open pilot study." 11/01/1975 - "Long-term treatment of hyperkinetic heart syndrome with propranolol." 01/01/1970 - "Propranolol in the treatment of hyperkinetic heart syndrome, idiopathic hypertrophic subaortic stenosis, and systemic hypertension."
10.	Oxygen (Dioxygen)IBA 11/01/1984 - "[The oxygen supply in patients with neurocirculatory asthenia during exercise]." 09/01/2003 - "56 patients with neurocirculatory asthenia (NCA) of a hypertensive and cardial type aged 30 to 55 years took general oxygen baths and collar zone massage, no drugs were used. " 05/01/1989 - "Oxygen metabolism kinetics (OMK) was investigated in 90 pregnant females with high risk for late gestoses and associated vascular disorders (essential hypertension, stage I, and neurocirculatory asthenia of hyper- and hypotonic type) exposed to preventive treatment with intermitting normobaric hypoxia (INH). " 01/01/1997 - "Adaptation to periodic hypoxia (decompression 490 mm Hg) in a multiplace medical pressure chamber of patients with hypertension, cardial neurocirculatory asthenia, coronary heart disease produced a persistent hypotensive effect with improvement of central and peripheral hemodynamics, oxygen homeostasis, electrolyte balance of blood. " 05/01/1972 - "However, four patients with functional murmurs, three patients with hyperkinetic heart syndrome, six patients with normal pulmonary artery pressures and intracardiac left to right shunts, and five patients with renal failure and anemia all increased their pulmonary vascular resistances when they breathed 10% oxygen in nitrogen. "

Therapies and Procedures

1.	Baths 12/05/2017 - " The objective of the present study was to provide the scientifically sound substantiation of the feasibility of the application of the non-medicamentous methods (including the interval hypoxic training and «dry» carbonic baths) for the prevention and treatment of neurocirculatory asthenia complicated by enhanced meteosensitivity and evaluate the therapeutic effectiveness of these approach. " 12/05/2017 - "The application of the non-medicamentous therapeutic modalities (including interval hypoxic training and «dry» carbonic baths) for the management of the meteosensitive patients presenting with neurocirculatory asthenia is pathogenetically justified, and they can be recommended for both the treatment and prevention of weather- dependent pathological processes and their exacerbations. " 09/01/2003 - "56 patients with neurocirculatory asthenia (NCA) of a hypertensive and cardial type aged 30 to 55 years took general oxygen baths and collar zone massage, no drugs were used. " 01/01/1957 - "[Evaluation of climatotherapy with salt water baths in neurocirculatory asthenia in children]."
2.	Therapeutics 06/01/2008 - "To find an effective therapy for cardiac neurosis. " 01/01/1985 - "The therapies of 3 patients suffering from cardiac neurosis are reviewed to illustrate the three main kinds of disorders in orientation. " 01/01/1984 - "At present beta-blockers are the therapy recommended in hyperkinetic heart syndrome. " 01/01/1978 - "[Exertion insufficiency during beta blocker therapy in the hyperkinetic heart syndrome]." 01/01/1969 - "[Diagnosis and therapy of the hyperkinetic heart syndrome]."
3.	Drug Therapy (Chemotherapy) 01/01/1992 - "Chemotherapy, physical and psychological treatment in day hospital produced a response in 89.2% of neurocirculatory asthenia sufferers." 01/01/1997 - "Clinical effect of baroadaptation to hypoxia manifesting in symptom relief permitted the physicians to diminish the intensity of chemotherapy and to abolish it in patients with neurocirculatory asthenia."
4.	Ear Acupuncture 06/01/2008 - "Auricular acupuncture combined with body acupuncture is the best method for treatment of cardiac neurosis." 06/01/2008 - "[Observation on therapeutic effect of auricular acupuncture combined with body acupuncture for treatment of cardiac neurosis]."
5.	Gamma Cameras (Gamma Camera) 03/31/1975 - "Minimal transit times (MTTs) were determined with the Fucks-Knipping gamma camera from differences between arrival times in consecutive cardiac compartments of blood radioactively labelled with 113m-In-DTPA Measurements were made on 50 patients with effort syndrome, 59 patients with hyperthyroidism before and after thyroid suppression therapy partly suffering from associated heart disease, and 25 patients with hypothyroidism before and after therapy with thyroid hormone. "