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Neuritis (Polyneuritis)

A general term indicating inflammation of a peripheral or cranial nerve. Clinical manifestation may include PAIN; PARESTHESIAS; PARESIS; or HYPESTHESIA.

Also Known As:

Polyneuritis; Peripheral Neuritis; Neuritis, Motor; Neuritis, Peripheral; Neuritis, Sensory; Motor Neuritides; Motor Neuritis; Neuritides; Neuritides, Motor; Neuritides, Peripheral; Neuritides, Sensory; Peripheral Neuritides; Polyneuritides; Sensory Neuritides; Sensory Neuritis

Networked: 793 relevant articles (25 outcomes, 38 trials/studies)

Relationship Network

Disease Context: Research Results

Nervous System Diseases: 6158
- Neuromuscular Diseases: 1068
  - Peripheral Nervous System Diseases: 5557
    - Neuritis: 793
      - Experimental Autoimmune Neuritis: 377
      - Brachial Plexus Neuritis: 106

Related Diseases

1.	Neuritis (Polyneuritis)
2.	Arthritis (Polyarthritis)
3.	Foot Ulcer
4.	Pain (Aches)
5.	Meningitis

Experts

1.	Eliav, Eli: 3 articles (04/2015 - 05/2009)
2.	Benoliel, Rafael: 3 articles (04/2015 - 05/2009)
3.	Dilley, Andrew: 3 articles (11/2013 - 10/2005)
4.	Friess, Helmut: 3 articles (01/2013 - 01/2009)
5.	Ceyhan, Güralp O: 3 articles (01/2013 - 01/2009)
6.	Giese, Nathalia A: 3 articles (01/2013 - 01/2009)
7.	Xie, Jing: 3 articles (11/2009 - 07/2006)
8.	Kar, H K: 3 articles (10/2009 - 06/2000)
9.	Boffeli, Troy J: 2 articles (05/2015 - 01/2012)
10.	Khan, Junad: 2 articles (04/2015 - 04/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Neuritis:

1.	Doxycycline (Vibramycin)FDA LinkGeneric 01/01/2004 - "Oral Doxycycline is useful in the treatment of neuritis without central nervous system involvement." 03/01/2007 - "However, numerous European studies have shown that oral doxycycline is equally effective in patients with Lyme meningitis and cranial neuritis (Class II and III). " 07/03/2007 - "Although most studies have used parenteral regimens for neuroborreliosis, several European studies support use of oral doxycycline in adults with meningitis, cranial neuritis, and radiculitis (Level B), reserving parenteral regimens for patients with parenchymal CNS involvement, other severe neurologic symptomatology, or failure to respond to oral regimens. "
2.	Immunoglobulin G (IgG)IBA 06/15/2009 - "Polyneuritis cranialis presenting with anti-GQ1b IgG antibody." 04/01/2001 - "This case illustrates that the diagnosis of borreliosis in patients with isolated painful peripheral neuritis cannot be based solely upon positive IgG titers and supports the requirement for a thorough workup for an underlying--potentially curable--disease. " 01/01/2001 - "Polyneuritis cranialis related to anti-GT1 a IgG antibody." 10/16/1999 - "In comparison with non familiar forms FMS patients in Spain, present more often remitting courses, are less disabled, optical neuritis is more frequently seen as onset symptom and IgG synthesis is more often increased." 05/01/1984 - "During neuritis, nine of 10 patients had higher specific IgG antibody titers (greater than 1:200) than did controls, and when arthritis was present, all had such titers, which remained elevated after months of remission. "
3.	Insulin (Novolin)FDA Link 03/01/1996 - "Insulin neuritis, or painful neuropathy following rapid improvement in glycaemic control, is well recognised but its aetiology is unclear. " 01/01/2015 - "Treatment-induced neuropathy in diabetes (also referred to as insulin neuritis) is considered a rare iatrogenic small fibre neuropathy caused by an abrupt improvement in glycaemic control in the setting of chronic hyperglycaemia. " 02/01/2015 - "insulin neuritis). " 05/01/2013 - "As with insulin neuritis, this condition is reversible over weeks to months after adequate diabetic control. " 05/01/2013 - "Insulin neuritis and diabetic cachectic neuropathy: a review."
4.	Prednisolone (Predate)FDA LinkGeneric 10/01/1990 - "These symptoms and laboratory data, except neuritis, improved by an administration of prednisolone. " 09/01/2000 - "A total of 197 neuritis cases were detected and treated with prednisolone out of 1 407 new or active cases. " 09/01/2008 - "Fifty five people with neuritis were detected and treated with prednisolone out of 262 new patients; 47 of these improved; 1130 people completed a 3-year self-care programme; 88.5% of red eyes, 83.9% of hand ulcers and 62.8% of simple foot ulcer cases healed during that period. " 06/01/2008 - "A cohort of 400 untreated MB patients were sub-grouped into those to be treated with corticosteroids (prednisolone 40 mg daily tapered to 5 mg over 12 weeks) along with MB-MDT for reaction and/or neuritis or silent neuropathy (SN) of <6 months duration (group A), and those with no reaction and to be treated with MDT only (group B). " 10/15/1960 - "[Treatment of polyneuritis with prednisone and prednisolone]."
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1983 - "It is demonstrated that when multiple modality treatment (with corticosteroids as a component) is initiated at the early stages of disease, some patients exhibit prolonged remission of nodular periarteritis, including notable regression of polyneuritis manifestations." 03/01/2015 - "Exacerbation of the immune response against Mycobacterium leprae can lead to neuritis, which is commonly treated via immunosuppression with corticosteroids. " 02/01/2010 - "They were subgrouped as those to be treated with 12-week regimen of corticosteroids for reaction and/or neuritis or silent neuropathy of <6 months duration along with 12-month multidrug therapy (group A), and those with no reaction were treated with multidrug therapy only (group B). " 12/01/2001 - "Among 17 operations, 14 were performed for painful neuritis of recent onset unsuccessfully treated with corticoids or recurring during the month after corticoids were withdrawn. " 01/01/1983 - "Chronic polyneuritis responds to treatment with corticosteroids. "
6.	Immunoglobulin M (IgM)IBA 01/01/1988 - "One had axonal neuropathy with IgM activity against the peri- and endoneurium, while another case with post-infectious neuritis had IgM activity against structures in the endoneurium but no IgM autoimmunity in the direct fluorescence test. " 10/01/1984 - "At each stage, some patients, particularly those with neuritis or carditis, had elevated serum IgM levels and lymphopenia. " 02/01/2010 - "A marked improvement of symptoms was achieved after i.v. immunoglobulin therapy that was initiated following identification of serum IgM anti-GM 1 ganglioside antibodies under suspicion of cranial polyneuritis. " 10/04/1986 - "[Polyneuritis and essential mixed cryoglobulinemia with demonstration of deposits of IgM and IgA in the vascular walls of the nerve]." 11/01/1993 - "Several studies on myelin proteins in the PNS have indicated that the L2/HNK-1 epitope, which is believed to be both a ligand for cellular adhesion and a target for autoimmune monoclonal IgM neuritis, may be found on heretofore unidentified proteins with a molecular mass of 19-28 kDa. In this report, we provide immunological evidence that at least one of these proteins is PMP-22."
7.	AntibodiesIBA 01/01/2014 - "This is the first case of CAR with presence of anti-CV2/CRMP5 antibodies without neuritis. " 03/01/1994 - "The anti-protein F1 antibodies also stained the plasma membranes of cell bodies and neuritis of mouse neuronal cultures obtained from 14-day old spinal embryonic tissue. " 01/01/1974 - "[Myelinotoxic antibodies in the serum of rabbits with experimental allergic polyneuritis]." 01/01/1971 - "[Nerve tissue culture method of studying myelinotoxic antibodies in experimental allergic polyneuritis]." 07/01/2000 - "Molecular mimicry in infectious encephalitis and neuritis: binding of antibodies against infectious agents on Western blots of human nervous tissue."
8.	Nitrofurantoin (Macrodantin)FDA LinkGeneric 03/01/1980 - "[Protection against experimental neuritis caused by nitrofurantoin]." 12/01/1977 - "[Possibility of limitation and prevention of functional damage in experimental neuritis due to nitrofurantoin]." 02/01/1977 - "[Prevention of experimental neuritis induced by nitrofurantoin and triorthocresylphosphate]." 01/08/1971 - "[Nitrofurantoin-polyneuritis]." 12/16/1968 - "[A case of polyneuritis in the course of long-term treatment with nitrofurantoin]."
9.	Thalidomide (Thalomid)FDA Link 03/01/2015 - "She responded dramatically to Thalidomide with regression of cutaneous lesions and neuritis. " 09/01/2013 - "The incidence of peripheral neuritis was not significantly related to the maximal and initial dose of thalidomide (P > 0.05). " 09/01/2004 - "The results point out to the association between ENL and neuritis and the rare adoption of thalidomide as a solely medication in the health services." 10/01/2003 - "During the year 1961 it became evident that intake of thalidomide in therapeutic doses could result in severe peripheral neuritis and, when taken early in pregnancy, in horrendous damage to the fetus. " 07/01/1980 - "Treatment with thalidomide in steroid dependency and neuritis."
10.	SteroidsIBA 01/01/2007 - "Type 1 reaction when developed as such, or as IRIS, needs oral steroids in adequate doses, particularly when associated with neuritis and motor loss, since lower doses may not be able to reverse the motor loss even of early onset. " 12/01/1992 - "Low-dose oral steroids did not improve visual function at any time and carried a higher risk for new episodes of neuritis, compared to placebo. " 12/01/1989 - "Decompression along with steroids gave better results than decompression alone in patients with active neuritis especially in BT cases whereas in BB, BL and LL cases there was no significant improvement of sensation. " 08/01/2012 - "Antileprosy, anti-inflammatory drugs, and steroids were given in view of neuritis because of lepra reaction with supportive measures of physiotherapy, transcutaneous electrical nerve stimulation, to no avail. " 09/01/2001 - "This paper describes a pilot project to investigate the potential of health personnel in the leprosy programme and the dermatology and sexually transmitted diseases services to (a) prevent deterioration of existing disabilities in ex-patients through self-care and (b) prevent new neuritis in patients on MDT through early detection and the use of steroids."

Therapies and Procedures

1.	Decompression 09/01/1996 - "Fifty-seven ulnar nerves in 39 patients with early neuritis were studied to assess the benefits offered by medial epicondylectomy and external decompression in addition to steroid therapy. " 12/01/1984 - "Sixty-two ulnar nerves belonging to 44 patients with early neuritis were studied to assess the benefits offered by medial epicondylectomy and external decompression in addition to steroid therapy. " 01/01/1977 - "Thirty-two simple decompression operations were performed on 31 patients, diagnosed as suffering from compression neuritis of the ulnar nerve. " 01/01/1977 - "Compression neuritis of the ulnar nerve treated with simple decompression." 07/01/1968 - "Decompression of the ulnar and median nerves in leprous neuritis."
2.	Plasma Exchange 08/01/1987 - "No improvement in acute polyneuritis was observed with serial plasma exchange. " 01/01/1990 - "Plasma exchange procedures are now possible in pregnant women and the benefits of this treatment have been illustrated in severe forms of polyneuritis. " 12/10/1988 - "A review of the literature suggests that plasma exchange can at least be recommended in severe cases of Guillain-Barré acute polyneuritis with inability to walk. " 03/01/1986 - "Following a review of pertinent literature, nine cases of chronic polyneuritis are reported, who underwent a total of 21 series of plasma exchange treatment during immunosuppressive medication. " 03/01/1986 - "[Plasma exchange treatment in chronic polyneuritis of the Guillain-Barré type. "
3.	Blood Transfusion (Blood Transfusions) 10/10/1952 - "[Ascending allergic polyneuritis caused by repeated blood transfusion]." 03/20/1951 - "[Fatal polyneuritis following blood transfusion]." 05/01/1999 - "Nightblindness, angular stomatitis, neuritis, and petechial haemorrhages improved with appropriate treatment; 2 patients were given blood transfusion for post-treatment anaemia. "
4.	Transplants (Transplant) 05/01/2008 - "Postoperative complications included nonunion in 1 patient, subsidence of graft (collapse) in 1 patient, wound dehiscence in 3 patients, painful hardware in 7 patients, sural neuritis in 1 patient, superior cluneal nerve dysfunction in 1 patient and one mild varus malunion. " 01/01/2015 - "Effective treatment of cytomegalovirus retinitis and neuritis with retrobulbar ganciclovir after treosulfan-based autologous bone marrow transplant."
5.	Sutures (Suture) 11/01/2002 - "The average lower instrumented vertebra was L2.6. Complications included one intercostal neuritis that resolved with suture removal, one broken inferior screw that healed with some loss of correction, and one pseudarthrosis treated successfully with posterior fusion. " 12/01/2013 - "However, complications including neuritis of the superficial peroneal or sural nerve, and pain or discomfort due to a prominent anchor or suture knot have been reported. "