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Netilmicin (Netromycin)

Semisynthetic 1-N-ethyl derivative of SISOMYCIN, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity.

Also Known As:

Netromycin; Certomycin; Essex Brand of Netilmicin Sulfate; Merck Brand of Netilmicin; Netillin; Netilmicin Sulfate; Netrocin; Netromicina; Netromycine; Nétromicine; Pfizer Brand of Netilimicin; Sch-20569; Netilimicin Pfizer Brand; Netilmicin Merck Brand; Sch 20569; Sch20569; D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-N1-ethyl-

Networked: 414 relevant articles (69 outcomes, 84 trials/studies)

Relationship Network

Drug Context: Research Results

Carbohydrates: 4088
- Glycosides: 547
  - Aminoglycosides: 1446
    - Gentamicins: 5166
      - Sisomicin: 123
        Netilmicin: 414
        6'-N-alanylnetilmicin

Experts

1.	Papa, Vincenzo: 3 articles (01/2013 - 01/2002)
2.	Faraldi, Francesco: 2 articles (01/2013 - 01/2012)
3.	Santoro, Debora: 2 articles (01/2013 - 01/2012)
4.	Rasà, Daria: 2 articles (01/2013 - 01/2012)
5.	Russo, Simona: 2 articles (01/2013 - 01/2012)
6.	Marlow, N: 2 articles (01/2004 - 03/2000)
7.	Bastida, Adrian Zaragoza: 1 article (12/2015)
8.	Elghandour, Mona Mohamed Mohamed Yasseen: 1 article (12/2015)
9.	Rojas-Hernández, Saul: 1 article (12/2015)
10.	DiLorenzo, Nicolas: 1 article (12/2015)

Related Diseases

1.	Infection 01/01/1981 - "The results of this study demonstrate that netilmicin is both effective in the treatment of serious systemic infections and well tolerated when administered at 150 mg twice daily." 05/01/1978 - "These studies suggest that netilmicin is effective in serious gram-negative bacillary infections, but is nephrotoxic and ototoxic in humans." 01/20/1979 - "Netilmicin appears to be effective and safe in the treatment of aerobic gram-negative infections." 01/01/1979 - "Netilmicin appears to be an effective, safe agent for the therapy of serious infections." 07/01/1990 - "Data obtained proved the efficacy of netilmicin in preventing postcystoscopy urinary infections in 87% of the cases. "
2.	Peritonitis 05/01/1995 - "Peritonitis was treated with intraperitoneal administration of cefacin and/or netromycin when suspected, and 52.9% of the episodes needed hospitalization. " 06/24/1987 - "Five patients who managed their peritonitis at home had dialysate and plasma netilmicin levels estimated at two and six days. " 06/24/1987 - "We conclude that netilmicin can be used effectively in the majority of microbiologically undifferentiated episodes of CAPD peritonitis, including in the home setting." 11/01/1996 - "Since little is known about the efficacy of single daily intraperitoneal application of netilmicin in the treatment of CAPD-associated peritonitis, we conducted this prospective study. " 11/01/1996 - "Hence, a single daily dosage of netilmicin can be a suitable treatment of CAPD-associated peritonitis, only if the dose is adapted according to the first serum and peritoneal levels. "
3.	Urinary Tract Infections (Urinary Tract Infection) 04/25/1984 - "Netilmicin is another drug which is highly effective when used in a single dose regimen for the treatment of uncomplicated urinary tract infections. " 07/01/1985 - "Single-dose netilmicin therapy is an effective and safe regimen for complicated and uncomplicated urinary tract infections in children. " 05/28/1980 - "Fourteen of 15 patients with a severe or complicated urinary tract infection were cured by treatment with a seven day course of netilmicin. " 08/01/1982 - "[Clinical study on netilmicin in the treatment of complicated urinary tract infection caused by Pseudomonas aeruginosa]." 05/01/1990 - "The authors submit the results of treatment of non-complicated urinary tract infections by a single dose of netilmicin. "
4.	Endocarditis 09/01/1993 - "We performed experiments in rats aimed at determining whether a combination of ceftriaxone (CRO) and netilmicin (NET), by using once-daily administration in rats, which simulated profiles of drug in human serum, was more effective than either agent alone in the treatment of endocarditis caused by viridans group streptococci. " 12/01/1990 - "We evaluated the efficacy of penicillin, alone or in combination with various dosing regimens of netilmicin, for the treatment of experimental left-sided Enterococcus faecalis endocarditis in rabbits. " 11/01/1989 - "Salmonella endocarditis was cured with administration of ampicillin and netilmicin for one month. " 05/01/2005 - "Gentamicin induced ototoxicity during treatment of enterococcal endocarditis: resolution with substitution by netilmicin." 07/01/2002 - "enterocolitica endocarditis and was successfully treated with a combination of drugs consisting of a quinolone (ofloxacin) and an aminoglycoside (netilmicin)."
5.	Fever (Fevers) 03/01/2005 - "Once-daily netilmicin for neutropenic pyrexia in paediatric oncology." 08/01/1988 - "Over a two year period 174 evaluable episodes of fever in neutropenic patients were treated in a randomized study comparing four beta-lactam antibiotics, each given in combination with netilmicin. " 03/01/2005 - "To establish the safety and efficacy of single daily intravenous netilmicin 6 mg/kg with piperacillin 100 mg/kg every 8 h for empirical, first-line management of children with neutropenic pyrexia following cytotoxic chemotherapy. " 05/01/1988 - "Thirteen episodes of fever in bone marrow transplantation recipients (23 months to 11 years old children) were treated by ceftazidime (100-200 mg/kg/j) and netilmicin (7 mg/kg/j). " 03/01/1993 - "Intravenous antibiotic therapy with penicillin G and netilmicin was instituted, but mitral insufficiency appeared 7 days later while the fever persisted. "

Related Drugs and Biologics

1.	Clindamycin (Cleocin)
2.	Gentamicins (Gentamicin)
3.	Vancomycin
4.	Ciprofloxacin (Cipro)
5.	Piperacillin
6.	Amikacin (A.M.K)
7.	Tobramycin (Nebcin)
8.	Ceftriaxone (Ceftriaxon)
9.	Ampicillin (Omnipen)
10.	Metronidazole (Metric)

Related Therapies and Procedures

1.	Continuous Ambulatory Peritoneal Dialysis (CAPD)
2.	Drug Therapy (Chemotherapy)
3.	Peritoneal Dialysis
4.	Antibiotic Prophylaxis
5.	Therapeutics