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Nerve Growth Factors (Neurotrophins)

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Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.

Also Known As:

Neurotrophins; Neurotrophic Factors; Growth-Associated Proteins, Neuronal; Neuronal Growth-Associated Proteins; Neuronotrophic Factors; Neurotrophic Protein; Neurotrophic Proteins; Proteins, Neuronal Growth-Associated; Factors, Nerve Growth; Factors, Neurite Outgrowth; Factors, Neuronotrophic; Factors, Neurotrophic; Growth Associated Proteins, Neuronal; Neuronal Growth Associated Proteins; Outgrowth Factors, Neurite; Neurite Outgrowth Factors

Networked: 1961 relevant articles (76 outcomes, 223 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Aloe, Luigi: 13 articles (01/2015 - 08/2003)
2.	Sharma, Hari Shanker: 12 articles (02/2012 - 01/2005)
3.	Renz, Harald: 11 articles (01/2012 - 02/2003)
4.	Piedimonte, Giovanni: 10 articles (01/2013 - 07/2005)
5.	Kapczinski, Flávio: 9 articles (09/2015 - 10/2006)
6.	Quevedo, João: 9 articles (09/2015 - 10/2006)
7.	Braun, Armin: 9 articles (05/2009 - 02/2003)
8.	Aloe, L: 9 articles (02/2006 - 04/2000)
9.	Bartus, Raymond T: 8 articles (10/2013 - 12/2007)
10.	Shepherd, Robert K: 7 articles (01/2015 - 09/2005)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 09/01/2001 - "Since neurotrophins themselves are not ideal drug candidates due to their poor pharmacokinetic behaviour and bioavailability, small molecule neurotrophin mimetics may be beneficial in treating a number of neurodegenerative disorders. " 11/01/2010 - "It is thought that the ability of human mesenchymal stem cells (hMSC) to deliver neurotrophic factors might be potentially useful for the treatment of neurodegenerative disorders. " 01/01/2012 - "Gene therapy holds much promise for the treatment of neurotrauma and neurodegenerative diseases; however, neurotrophic factors are known to alter dendritic architecture, and thus we set out to determine whether such transgenes also change the morphology of transduced neurons. " 11/10/1996 - "Neurotrophic factors hold promise for the treatment of neurodegenerative diseases. " 01/01/1994 - "For example, neurotrophins might function as long term mediators of changes in cellular shapes under the influence of electrical activity, as well as in pathological situations when axonal elongation is needed to restore connections, or to maintain the well-being of neurons that are eliminated during the course of neurodegenerative diseases."
2.	Spinal Cord Injuries (Spinal Cord Injury) 03/01/1997 - "The combined use of specific neurotrophic factors and the IN-1 antibody in different experimental procedures, including spinal cord injury, have significantly improved regenerative axonal growth. " 11/01/1998 - "Neurotrophic factors have been proposed as a therapeutic treatment for traumatic brain and spinal cord injury. " 10/05/2012 - "We hypothesized that enteric glia may exert their protective effects against spinal cord injury partially through the secretion of neurotrophic factors. " 05/01/2007 - "Fibrillation potentials following spinal cord injury: improvement with neurotrophins and exercise." 01/01/2007 - "Grafted human neural stem cells (hNSCs) may help to alleviate functional deficits resulting from spinal cord injury by bridging gaps, replacing lost neurons or oligodendrocytes, and providing neurotrophic factors. "
3.	Parkinson Disease (Parkinson's Disease) 11/01/2015 - "Gene therapy approaches delivering neurotrophic factors have offered promising results in both preclinical and clinical trials of Parkinson's disease (PD). " 04/30/2013 - "In an effort to account for deficiencies in axonal transport that limit the effectiveness of neurotrophic factors, this study tested the safety and feasibility, in moderately advanced Parkinson disease (PD), of bilaterally administering the gene therapy vector AAV2-neurturin (CERE-120) to the putamen plus substantia nigra (SN, a relatively small structure deep within the midbrain, in proximity to critical neuronal and vascular structures). " 01/01/2010 - "Studies in non-human primates and patients with Parkinson's disease confirmed further the induction of these specified neurotrophic factors. " 10/01/2004 - "To date, the supplementation of neurotrophic factors and substitution for the dopaminergic deficit have formed the focus of trials to achieve relief in animal models of Parkinson's disease. " 08/01/1996 - "The result of clinical trials utilizing neurotrophic factors, both as mesencephalic implant support strategies and as definitive treatment of idiopathic Parkinson's disease, are awaited with cautious optimism."
4.	Stroke (Strokes) 07/23/2004 - "The results revealed significant reduction of behavioral deficits and infarct volumes, accompanied by increased levels of neurotrophic factors, as detected by ELISA, in transplanted ischemic striatum collected from CB-grafted stroke animals. " 01/01/2006 - "Expressions of various neurotrophic factors or their receptors fluctuate after stroke, which in part prompted investigations into the efficacy of neurotrophic factors as treatment modality for stroke. " 10/01/2013 - "Even so, this study shows that P2X7 can be targeted with systemic drug treatments to differentially regulate neurotrophic factors in the brain following stroke. " 08/01/2014 - "The mechanisms involved in tissue regeneration and the mode of the participation of stem/progenitor cells and soluble protein neurotrophic factors in this process may yield a more complete understanding of the nature of stroke. " 04/01/2013 - "A thorough evaluation of neurotrophins is still necessary to determine their time-dependent contributions against injury and their modulatory effects on repair after stroke."
5.	Inflammation 07/01/2013 - "Administration of human CB cells in animal models of HIE has generally resulted in improved outcomes and multiple mechanisms have been suggested including anti-inflammation, release of neurotrophic factors and stimulation of endogenous neurogenesis. " 10/05/2014 - "Numerous studies have demonstrated that inflammation, oxidative stress and altered level of neurotrophins are involved in the pathogenesis of depressive illness. " 01/01/2013 - "In the recent years numerous studies have analysed the effects of neurotrophins on allergic inflammation in airway diseases reporting increased neurotrophin levels locally in the airways as well as in serum of asthmatic patients. " 09/01/2008 - "The aim of this study was to determine the impact of CPB on plasma neurotrophins levels and to appreciate the links existing between inflammation, oxidative stress and neurotrophins. " 11/01/2007 - "The aim of the study was to investigate the precise mechanisms of neurotrophins in neuroimmune interaction, which can lead to both airway inflammation and sensory nerve hyperreactivity in vivo. "

Related Drugs and Biologics

1.	Brain-Derived Neurotrophic Factor (BDNF)
2.	Nerve Growth Factor (NGF)
3.	Antioxidants
4.	Glial Cell Line-Derived Neurotrophic Factor (GDNF)
5.	Dopamine (Intropin)
6.	Cytokines
7.	Nerve Growth Factors (Neurotrophins)
8.	Insulin (Novolin)
9.	Neurotransmitter Agents (Neurotransmitter)
10.	Neuropeptides

Related Therapies and Procedures

1.	Transplants (Transplant)
2.	Transplantation (Transplant Recipients)
3.	Ligation
4.	Cochlear Implants (Cochlear Implant)
5.	Electroacupuncture