Lipoid Nephrosis (Glomerulonephritis, Minimal Change)

A kidney disease with no or minimal histological glomerular changes on light microscopy and with no immune deposits. It is characterized by lipid accumulation in the epithelial cells of KIDNEY TUBULES and in the URINE. Patients usually show NEPHROTIC SYNDROME indicating the presence of PROTEINURIA with accompanying EDEMA.

Also Known As:

Networked: 302 relevant articles (21 outcomes, 15 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Proteinuria
2.	Membranous Glomerulonephritis (Membranous Nephropathy)
3.	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal)
4.	Nephrotic Syndrome (Syndrome, Nephrotic)
5.	IGA Glomerulonephritis (IGA Nephropathy)

Experts

1.	Li, Xiayu: 3 articles (05/2012 - 04/2009)
2.	Chen, Jianghua: 3 articles (05/2012 - 04/2009)
3.	Li, Heng: 3 articles (05/2012 - 04/2009)
4.	Kopp, Jeffrey B: 3 articles (06/2009 - 05/2007)
5.	Li, Qun: 2 articles (07/2009 - 04/2009)
6.	He, Qiang: 2 articles (07/2009 - 04/2009)
7.	Chen, Yilun: 2 articles (07/2009 - 04/2009)
8.	Han, Fei: 2 articles (07/2009 - 04/2009)
9.	Barisoni, Laura: 2 articles (02/2009 - 05/2007)
10.	Schnaper, H William: 2 articles (02/2009 - 05/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lipoid Nephrosis:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/1991 - "Adults with minimal-change nephropathy usually require a prolonged administration of corticosteroids to achieve remission which, in itself, carries the risk of severe and even life-threatening complications. " 11/01/1996 - "Adult-onset minimal-change nephropathy has been associated with a slower response to corticosteroids and a less benign prognosis when compared to children. " 08/01/1993 - "Minimal change nephropathy is a disease of children which generally responds to corticosteroids. " 05/01/1975 - "Two cases are reported in this article: case 1 is a girl followed for the last fifteen years when she had lipoid nephrosis which was treated initially with corticosteroids; she responded satisfactorily, but presented frequent relapses. " 11/01/1999 - "Corticosteroids result in remission of proteinuria in most patients with minimal change nephropathy. "
2.	Prednisone (Sone)FDA LinkGeneric 01/01/1996 - "Percutaneous renal biopsy allowed us to confirm the diagnosis of minimal change glomerulopathy; she entered a 2-year period of remission after a 6-month course of prednisone (starting dose 1.5 mg/kg). " 09/05/1992 - "Seven out of 14 patients with minimal change nephropathy remained in remission following discontinuation of prednisone and in 4 others the dose of steroid required to maintain remission decreased. " 03/01/1986 - "On the while alternate-day prednisone therapy does not affect statural growth and bone maturation of children with lipoid nephrosis." 12/26/1998 - "Prednisone monotherapy is the treatment of choice for patients with a nephrotic syndrome due to minimal change glomerulopathy. " 09/01/1958 - "[Effect of epidemic parotitis & prednisone in lipoid nephrosis]."
3.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 07/12/1984 - "Cyclophosphamide for minimal-change nephropathy in children." 02/16/1984 - "Modulation of cellular immune function by cyclophosphamide in children with minimal-change nephropathy." 01/31/1981 - "Long-term impairment of suppressor-cell function by cyclophosphamide in minimal-change nephropathy and its association with therapeutic response." 05/01/1967 - "Cyclophosphamide in the treatment of idiopathic lipoid nephrosis." 02/16/1984 - "Cyclophosphamide is widely used to induce a remission of minimal-change nephropathy, but concerns have been raised about whether its effects on cellular immunity persist after treatment is discontinued. "
4.	Concanavalin AIBA 07/01/1982 - "A group of 37 patients with minimal change nephropathy (MCN) in remission for a mean period of 4.9 years (range 0.25-10) and on no current treatment were found to have a lymphocyte response to the mitogen Concanavalin A which was significantly lower than normal (P less than 0.001). " 01/31/1981 - "Lymphocyte suppressor-cell function was studied by induction with concanavalin A in 31 patients with minimal-change nephropathy (MCN) in remission. " 08/01/1981 - "Concanavalin A-induced suppressor cell activity in lipoid nephrosis." 10/01/1984 - "The response of lymphocytes to Concanavalin A (Con A) was measured in patients with the nephrotic syndrome due to minimal change nephropathy (11 patients), focal glomerulosclerosis (15 patients) and membranous nephropathy (21 patients); autologous serum was not used in these studies. " 06/01/1981 - "Sera from patients with the nephrotic syndrome due to minimal change nephropathy (11 patients), membranous nephropathy (14 patients) and focal glomerulosclerosis (15 patients) inhibited the response of normal lymphocytes to the mitogen Concanavalin A. "
5.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/1988 - "Cyclosporin (mean initial dose 7.7 mg/kg per day) produced a complete remission of proteinuria in 15 nephrotic episodes in the ten patients with minimal-change nephropathy after a mean 14.3 days (range 7-23 days) of therapy. " 03/22/1986 - "These preliminary results show that cyclosporin A may be effective in the treatment of patients with nephrotic syndrome that resists every other form of treatment and especially in the treatment of those with minimal change lipoid nephrosis. " 01/01/1990 - "Ciclosporin in minimal-change glomerulopathy and in focal segmental glomerular sclerosis." 01/01/1988 - "Cyclosporin is an effective agent for the treatment of patients with frequently relapsing minimal-change nephropathy who became steroid dependent when cyclophosphamide is contraindicated. " 10/01/2009 - "The combined use of sirolimus and cyclosporin in the management of refractory minimal change nephropathy: 'a novel use of sirolimus'."
6.	Prednisolone (Predate)FDA LinkGeneric 02/01/1998 - "Treatment of primary glomerular diseases with severe (NS) includes frequently relapsing minimal change nephropathy (MCN) that can be treated with prednisolone 1 mg/kg/day until remission occurs. " 12/02/1957 - "[6 Cases of lipoid nephrosis treated with prednisolone]." 04/01/1984 - "A patient with minimal change nephropathy (MCN) is described who, during the earlier part of his illness, had several relapses each of which promptly responded to treatment with prednisolone but subsequently his proteinuria became refractory to this treatment for nearly two years. " 01/01/1996 - "Current results show that prednisolone is effective in minimal-change nephropathy, and in combination with other immunosuppressants it can reduce proteinuria in individual cases of focal and segmental glomerulosclerosis, membranous glomerulonephritis and nephrotic IgA nephropathy. "
7.	Immunoglobulin M (IgM)IBA 01/01/1991 - "This article seeks to clarify the situation by considering the case for treating minimal-change nephropathy, focal and segmental glomerulosclerotic lesions, and mesangioproliferative lesions with predominantly IgM deposition as separate disease entities. " 07/01/2000 - "Using SI based on alpha(2)-macroglobulin (alpha(2)-M-SI) or on IgM (IgM-SI) we found that minimal change nephropathy could be discriminated by low SI values and crescentic necrotizing glomerulonephritis by high SI values compared to other diseases. " 12/01/1998 - "Both alpha 2M SI and IgM SI were significantly lower in minimal change nephropathy and higher in crescentic necrotizing glomerulonephritis than in all the other diagnoses. " 01/01/1991 - "In INS, the histological appearance constitutes a classical prognostic element: minimal-change nephropathy (MCN) responds better to treatment than focal glomerulosclerosis (FGS) or IgM nephropathy (IgMN). " 11/01/2011 - "Sixteen patients received renal biopsy, of whom 6 revealed minimal change nephropathy with complete remission in 3 cases, 3 cases had partial remission;4 cases revealed focal segmental glomerulosclerosis with 2 complete remission and 2 partial remission; other 5 children with IgM nephropathy and 1 mesangial proliferative glomerulonephritis achieved complete remission. "
8.	Segmental glomerulosclerosisIBA 07/01/2015 - "Although uncommon, the clinical picture of CblC defects may be ruled by nephrotic syndrome mimicking glomerulonephritis, minimal change disease, or primary focal and segmental glomerulosclerosis. " 03/01/1993 - "These patients had minimal change nephropathy (MCN), focal and segmental glomerulosclerosis (FSGS), or membranous nephropathy (MN) on biopsy. " 03/01/1996 - "Initial reports on antiproteinuric effect of pefloxacine in small groups of patients with minimal-change nephropathy (MCN) and focal and segmental glomerulosclerosis (FSGS) have not been confirmed in other papers. " 10/18/1995 - "Antiproteinuric effect of pefloxacine was demonstrated in a small group of patients with minimal change nephropathy (MCN) and focal and segmental glomerulosclerosis (FSGS). " 01/01/1984 - "Serum IgE was significantly elevated in 39 lipoid nephrosis patients (p less than 0.001, with 21 levels greater than 460 IU/ml), 21 focal and segmental glomerulosclerosis (p less than 0.05, with 8 levels greater than 460 IU/ml) and 42 membranous GN (p less than 0.01, with 10 levels greater than 460 IU/ml). "
9.	Dextrans (Dextran)FDA Link 05/01/1991 - "Fractional clearances (theta) of uncharged dextrans (radii 28-60 A) were used to characterize glomerular dysfunction in 34 nephrotic humans with either minimal-change nephropathy (MCN) or focal, segmental glomerulosclerosis (FSGS). " 02/01/1981 - "To investigate the mechanism of proteinuria in minimal change nephropathy, the renal handling of dextrans was studied in seven nephrotic patients with this disorder. " 05/01/1980 - "Equivalent restriction to transglomerular passage of dextrans with a r < 36 A in 7 patients with minimal change nephropathy was associated with a similarly enhanced proteinuria (UalbV, 3333 +/ 759 microgram/min). " 02/01/1981 - "Since the fractional clearance of dextrans similar in size to albumin was depressed, not increased, it is proposed that the lack of electrostatic interaction between the glomerular capillaries and polyanionic plasma albumin (ESR = 36 A) accounts for the selective albuminuria which characterizes minimal change nephropathy." 05/01/1980 - "Furthermore, the fractional clearances for test proteins were two orders of magnitude smaller than that for equivalent-sized dextrans in minimal change nephropathy, whereas this difference was much less in diabetic nephropathy. "
10.	PefloxacinIBA 02/01/1997 - "Pefloxacin, a fluorinated 4-quinolone, has recently been advocated as a first-line treatment for minimal-change nephropathy (MCN) or focal segmental glomerulosclerosis (FSGS). " 03/01/1996 - "Initial reports on antiproteinuric effect of pefloxacine in small groups of patients with minimal-change nephropathy (MCN) and focal and segmental glomerulosclerosis (FSGS) have not been confirmed in other papers. " 10/18/1995 - "Antiproteinuric effect of pefloxacine was demonstrated in a small group of patients with minimal change nephropathy (MCN) and focal and segmental glomerulosclerosis (FSGS). "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 12/01/1988 - "A significantly shorter length of remission after cytotoxic drug therapy (p less than 0.05) was identified for patients with FSGS versus those with lipoid nephrosis; this difference became more significant for steroid-resistant patients in comparison with those who were steroid dependent or were frequent relapsers (p less than 0.005). " 07/01/2014 - "We suggest there could be a predisposing anterior capsule weakness secondary to the minimal-change glomerulopathy or the associated drug therapy, but there needs to be more evidence to confirm or refute our claim. " 09/01/1969 - "[Immunodepressive chemotherapy in the therapy of lipoid nephrosis. " 08/01/1969 - "[Immunosuppressive chemotherapy of lipoid nephrosis. "
2.	Aftercare (After-Treatment) 02/16/1984 - "Cyclophosphamide is widely used to induce a remission of minimal-change nephropathy, but concerns have been raised about whether its effects on cellular immunity persist after treatment is discontinued. " 02/01/1992 - "[Neurectodermal malignant tumor of the soft tissues after treatment with immunosuppressive agents of lipoid nephrosis]."
3.	Transplants (Transplant) 07/01/1985 - "Depression of local graft-versus-host reaction in patients with lipoid nephrosis." 01/01/1982 - "Impaired local graft-versus-host reaction in lipoid nephrosis." 01/01/1982 - "Effect of thymic humoral factor on a local graft-versus-host reaction of lymphocytes in patients with lipoid nephrosis." 12/01/2004 - "Renal biopsies from 58 patients with diverse primary and secondary renal diseases were studied (hypertensive nephropathy n = 5, IgA glomerulopathy n = 8, minimal change nephropathy n = 7, diabetic nephropathy n = 8, focal glomerulosclerosis n = 5, vasculitis n = 7, and membranous glomerulopathy n = 18) in addition to 17 renal transplants and 18 samples from normal renal tissue. "
4.	Peritoneal Dialysis 06/30/1950 - "[Intractable edema during lipoid nephrosis successfully treated by peritoneal dialysis]." 02/09/1951 - "[Grave lipoid nephrosis; therapeutic effects of lipocaic and dechlorurant peritoneal dialysis]."
5.	Kidney Transplantation 12/27/2005 - "Sirolimus use and de novo minimal change nephropathy following renal transplantation."