Nephrosis

Pathological processes of the KIDNEY without inflammatory or neoplastic components. Nephrosis may be a primary disorder or secondary complication of other diseases. It is characterized by the NEPHROTIC SYNDROME indicating the presence of PROTEINURIA and HYPOALBUMINEMIA with accompanying EDEMA.

Also Known As:

Networked: 1483 relevant articles (64 outcomes, 181 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Proteinuria
2.	Nephrotic Syndrome (Syndrome, Nephrotic)
3.	Glomerulonephritis
4.	Hyperlipidemias (Hyperlipidemia)
5.	Membranous Glomerulonephritis (Membranous Nephropathy)

Experts

1.	Navis, Gerjan: 11 articles (02/2013 - 02/2002)
2.	Yamamoto, Tadashi: 10 articles (03/2011 - 01/2002)
3.	Yoshida, Yutaka: 9 articles (03/2011 - 01/2002)
4.	Yaoita, Eishin: 9 articles (03/2011 - 01/2002)
5.	Wang, Yiping: 7 articles (10/2013 - 01/2005)
6.	Nameta, Masaaki: 7 articles (03/2011 - 01/2002)
7.	Tomino, Yasuhiko: 6 articles (05/2015 - 01/2002)
8.	Tryggvason, Karl: 6 articles (09/2014 - 05/2002)
9.	Harris, David C H: 6 articles (10/2013 - 04/2005)
10.	Kramer, Andrea B: 6 articles (01/2013 - 09/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nephrosis:

1.	Puromycin AminonucleosideIBA 07/01/1999 - "Puromycin aminonucleoside nephrosis (PAN) results in a marked increase in the fractional clearance of albumin. " 07/01/1999 - "Puromycin aminonucleoside nephrosis results in a marked increase in fractional clearance of albumin." 07/28/2008 - "Protective effects of antithrombin on puromycin aminonucleoside nephrosis in rats." 01/01/2015 - "This study was designed to evaluate the underlying mechanism in the use of YQQRG formula to treat nephrosis induced by puromycin aminonucleoside (PAN). " 01/01/2013 - "We conducted this study to ask whether DHMEQ may ameliorate the nephrosis in mice induced by puromycin aminonucleoside (PAN), which is considered to be an animal model for MCNS. "
2.	Doxorubicin (Adriamycin)FDA LinkGeneric 10/01/2013 - "Since their relative therapeutic efficacy is unclear, we compared the effects of these two macrophage subsets in murine adriamycin nephrosis. " 01/01/2012 - "We investigated the protective effects and mechanism of action of SN in a rat model of doxorubicin (DOX)-induced nephrosis. " 06/01/2011 - "We investigated the mechanism of the protective effects of HQH on adriamycin nephrosis (ADR) in rats. " 01/01/2015 - "This study aims to explore the therapeutic effect of bone marrow mesenchymal stem cells on adriamycin nephrosis, and the potential mechanism. " 06/01/2008 - "The differential effects of nephrosis and vascular adriamycin exposure have to be accounted for in the interpretation of vascular studies in adriamycin nephrosis."
3.	Messenger RNA (mRNA)IBA 01/01/2008 - "The results of quantitative RT-PCR showed that expressions of CCL13 and HSPC159 mRNA in nephrosis PBMC samples were higher than those in remission samples from all 24 MCNS patients examined, while these mRNA expression patterns were variable among 10 MN patients. " 02/01/1995 - "These mRNA levels decreased to control levels by Day 20, when the nephrosis was in remission. " 06/01/2009 - "This study is the first to reveal increased mRNA expression levels of GATA-3 and Stat5A in PBMC from MCNS patients in nephrosis. " 07/10/2006 - "This study demonstrates that the mechanism by which ovarian steroid biosynthesis is altered during acute nephrosis involves damage at the P450scc and StAR mRNA synthesis and processing." 11/01/2008 - "Tissue samples were dissected out from the upper and middle intestines and liver after development of nephrosis to measure the expression levels of mRNA and protein. "
4.	SteroidsIBA 09/01/2009 - "Age at onset of nephrosis, beginning of first and second therapy, sex ratio, duration of nephrosis before first cytotoxic therapy, interval between first and second cytotoxic therapy, number of relapses, cumulative doses of steroids and length of remission off steroids before second therapy were similar between groups. " 05/01/1958 - "[Renal biopsy in children with nephrosis; a study of glomerular damage and the effect of steroids]." 10/01/1957 - "Needle biopsy in children with nephrosis: a study of glomerular damage and effect of adrenal steroids." 07/01/1960 - "[Treatment of nephrosis in the child with cortical steroids. " 08/14/1959 - "[The prolonged intermittent therapy of nephrosis with steroids; methods and results in children and adults]."
5.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/01/1977 - "Long term follow up of steroid and cyclophosphamide therapy in nephrosis." 03/10/1977 - "[Long-term follow-up of the effectiveness of cyclophosphamide in corticodependent and corticoresistant infantile nephrosis. " 06/01/1976 - "The two groups did not differ significantly as to age at onset of idiopathic nephrosis nor as to the duration of the INS prior to cyclophosphamide therapy. " 03/01/1975 - "Gonadal function in children with nephrosis treated with cyclophosphamide." 10/26/1974 - "Long-term assessment of cyclophosphamide therapy for nephrosis in children."
6.	Dietary ProteinsIBA 02/01/1986 - "To determine whether restriction of dietary protein will reduce urinary albumin excretion in patients with established nephrosis and whether such dietary restriction will result in decreased albumin pools, we performed paired studies on nine nephrotic patients. " 09/01/1996 - "In rats with PAN nephrosis, findings suggest that restriction of dietary protein leads to a reduction in glomerular SMemb expression." 06/01/1994 - "The results of this study suggest that dietary protein restriction attenuates TI fibrosis in PAN-induced nephrosis by partially reversing the increase in renal matrix synthesis. " 11/01/1936 - "THE EFFECT OF DIETARY PROTEIN ON THE UREA CLEARANCE OF CHILDREN WITH NEPHROSIS." 03/01/1994 - "To determine whether dietary protein restriction (LPD) causes protein catabolism in adriamycin nephrosis, nephrotic and control rats were paired by weight and gavage fed an 8.5% protein diet for 3 days (protocol 1) or 12 days (protocol 2). "
7.	CholesterolIBA 01/15/1982 - "These results are in accordance with previous studies showing enhanced cholesterol production in experimental nephrosis. " 11/01/1955 - "Studies on the mechanism of cholesterol synthesis in nephrosis." 09/01/2003 - "In conclusion, GSE administration decreases urine protein excretion and serum cholesterol and triglyceride levels in rats with PAN-induced nephrosis." 11/01/1992 - "Macrophages mediate adverse effects of cholesterol feeding in experimental nephrosis." 10/01/1992 - "To test this, three maneuvers to either raise or lower the glomerular macrophage number during acute PA nephrosis (2 weeks after PA) were employed: 1) an essential fatty acid-deficient (EFAD) diet; 2) a cholesterol-supplemented diet (CSD); and 3) a single dose (600 rad) whole-body X-irradiation (XI) given to CSD-fed PA rats. "
8.	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/01/1994 - "In this review, the results of both uncontrolled and controlled studies of the therapeutic effects of cyclosporine in steroid-sensitive/dependent idiopathic nephrosis and in steroid-resistant idiopathic nephrosis are analyzed. " 05/01/2013 - "Prospective 5-year follow-up of cyclosporine treatment in children with steroid-resistant nephrosis." 05/01/2001 - "Acute renal toxicity of cyclosporin A (CyA) may be responsible for osmotic nephrosis-like lesions. " 03/01/2000 - "Long-term clinical and pathological effects of cyclosporin in children with nephrosis." 12/01/1995 - "Cyclosporine in the treatment of idiopathic nephrosis."
9.	Lipoproteins (Lipoprotein)IBA 02/01/1997 - "The present results also suggest that the elevated plasma Lp(a) levels in nephrosis are related to an increased hepatic synthesis rather than a decreased catabolism of lipoproteins." 11/01/1996 - "Lipoprotein metabolism in experimental nephrosis." 01/01/1990 - "Catabolic defect of triglyceride is associated with abnormal very-low-density lipoprotein in experimental nephrosis." 12/15/1984 - "Lipoprotein metabolism in experimental nephrosis." 11/01/1981 - "With regard to atherogenicity of nephrosis, no salient, general lipoprotein-related change was discerned. "
10.	Adrenocorticotropic Hormone (ACTH)FDA Link 01/01/1952 - "Nephrosis; a long remission after ACTH." 10/01/1969 - "[Synthetic corticotropin in the treatment of nephrosis in childhood]." 06/15/1956 - "[ACTH therapy of nephrosis in children]." 10/01/1955 - "[ACTH therapy in nephrosis]." 01/01/1955 - "[Nephrosis and ACTH (with special reference to humoral changes observed in four cases cases)]."

Therapies and Procedures

1.	Nephrectomy 04/01/2004 - "We have performed the first quantitative immunoelectron microscopy study of alpha-actinin-4 expression in humans, analysing 12 cases of minimal change nephrosis (MCNS) and 16 cases of idiopathic membranous nephropathy (MGN), and comparing this with expression in normal tissue from seven nephrectomies (Nx). " 06/01/2000 - "We succeeded in developing a model of persistent nephrosis without severe glomerular abnormalities, nephrectomy or other manoeuvres known to induce disturbed haemodynamics, using an agent without tubulointerstitial toxicity, and considered it to be suitable for investigating the direct toxicity of proteinuria. " 06/01/1993 - "Kidney tissue was obtained from adults undergoing nephrectomy for renal tumor (n = 9) or biopsy for nephrosis and renal failure (n = 1). " 08/01/1993 - "Lipids were also measured to determine whether severe atherogenic abnormalities seen during nephrosis improved after nephrectomy. " 11/01/2015 - "Absence of osmotic nephrosis in renal tissue removed during laparoscopic nephrectomy after infusion of 6% Hydroxyethyl starch 130/0.4."
2.	Transplantation (Transplant Recipients) 11/01/2006 - "Osmotic nephrosis in a renal transplant recipient." 10/01/1993 - "Our data show that CNF patients have an increased tendency for post-transplantation nephrosis." 09/01/1982 - "Transplantation in idiopathic nephrosis." 08/01/1979 - "Following transplantation, nephrosis developed in three recipients. " 06/01/2010 - "Forty-five Sprague-Dawley rats were randomly divided into three groups (n=15 each): a nephrosis model group that received a single intraperitoneal injection of PAN (0.15 mg/g); a BMSC transplantation group that received a single intraperitoneal injection of PAN (0.15 mg/g) followed by BMSC transfusion; a control group that received a single intraperitoneal injection of normal saline. "
3.	Kidney Transplantation 08/01/2012 - "Our experience suggests that activated B cells may play a pivotal role in the recurrence of nephrosis after renal transplantation in children with CNS." 01/01/2003 - "To investigate sexual function before and after kidney transplantation in patients with chronic nephrosis. " 07/24/1993 - "Hydroxyethylstarch and osmotic-nephrosis-like lesions in kidney transplantation." 07/01/2010 - "We retrospectively reviewed the clinical records of 321 children seen with nephritis/nephrosis at the Pediatric Nephrology Unit, Soba University Hospital and Dr. Salma Dialysis and Kidney Transplantation Centre, Khartoum, Sudan during the period from 2002 to 2007. " 05/01/1993 - "Oxalate nephrosis and renal sclerosis after renal transplantation in a cat."
4.	Plasma Exchange 05/27/2007 - "Plasma exchange and retransplantation in recurrent nephrosis of patients with congenital nephrotic syndrome of the Finnish type (NPHS1)." 01/01/2005 - "Furthermore, plasma exchange or low density lipoprotein (LDL) apheresis could be a candidate for refractory nephroses, such as primal focal segmental glomerulosclerosis and can induce partial or complete remission."
5.	Blood Component Removal (Apheresis) 01/01/2005 - "Furthermore, plasma exchange or low density lipoprotein (LDL) apheresis could be a candidate for refractory nephroses, such as primal focal segmental glomerulosclerosis and can induce partial or complete remission."