Nephrocalcinosis

A condition characterized by calcification of the renal tissue itself. It is usually seen in distal RENAL TUBULAR ACIDOSIS with calcium deposition in the DISTAL KIDNEY TUBULES and the surrounding interstitium. Nephrocalcinosis causes RENAL INSUFFICIENCY.

Also Known As:

Networked: 767 relevant articles (19 outcomes, 42 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Hypercalciuria
2.	Hyperparathyroidism
3.	Hypercalcemia (Milk Alkali Syndrome)
4.	Nephrolithiasis
5.	Kidney Calculi (Kidney Stone)

Experts

1.	Konrad, Martin: 15 articles (04/2015 - 08/2002)
2.	Verhulst, Anja: 7 articles (01/2015 - 10/2005)
3.	Hou, Jianghui: 7 articles (01/2013 - 06/2007)
4.	D'Haese, Patrick C: 6 articles (01/2015 - 10/2005)
5.	Vervaet, Benjamin A: 6 articles (01/2015 - 10/2005)
6.	Goodenough, Daniel A: 6 articles (09/2010 - 06/2007)
7.	Sayer, John A: 5 articles (08/2015 - 01/2003)
8.	Evenepoel, Pieter: 5 articles (05/2015 - 08/2008)
9.	Haisch, Lea: 5 articles (04/2015 - 05/2009)
10.	Gambaro, Giovanni: 5 articles (04/2015 - 04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nephrocalcinosis:

1.	CalciumIBA 11/01/2014 - "This study aims at assessing the effects of calcium and phosphor supplementation in neonatal nephrocalcinosis by renal ultrasonography. " 09/01/1988 - "The exchangeable intrarenal calcium observed in this autoradiographic study was due to HgCl2-induced nephrocalcinosis." 10/01/1987 - "Studies were, therefore, performed to determine the effect of PTH on the renal handling of HCO3 in an animal model in which changes in plasma calcium and phosphate, and nephrocalcinosis, all known to affect tubular acidification, did not occur. " 11/01/2015 - "The presence of nephrocalcinosis positively correlated with urine calcium excretion (mean ± SD 287.39 ± 112.49 vs 223.68 ± 100.67 mg per day, p = 0.03). " 11/01/2015 - "Nephrocalcinosis in Calcium Stone Formers Who Do Not have Systemic Disease."
2.	CreatinineIBA 06/01/2004 - "In VLBW premature infants, close observation of acid-base status and regular analysis of spot urine specimens (Ca, P, creatinine) during the first weeks of life may help to identify those premature infants at risk for nephrocalcinosis." 01/01/2015 - "Serum creatinine was measured at 1, 3, 6, and 12 months after nephrocalcinosis was diagnosed. " 03/01/2005 - "The urinary ratio of beta2-microglobulin and creatinine (beta2M/Cr) was very high in a transplanted woman with nephrocalcinosis (> 3.23 mg/mmol) and slightly high in five patients (> 0.052 or < 1.0 mg/mmol) with multiple urological manipulations. " 06/01/2004 - "Moreover, the Ca/creatinine ratio in spot urine specimens tended to be higher (P<0.1) in patients developing nephrocalcinosis. " 08/01/1978 - "There was close correlation between hypercalcaemia, hyperuricaemia, nephrocalcinosis and creatinine clearance. "
3.	MagnesiumIBA 10/01/1999 - "Syndrome of renal magnesium wasting and nephrocalcinosis." 01/01/1999 - "Ionized hypomagnesemia was noted in a patient with normal total plasma magnesium in the context of hypercalciuric nephrocalcinosis of unknown origin. " 08/01/1998 - "We suggest that a magnesium-deficient diet not only induces nephrocalcinosis, but it also diminishes kidney function." 08/01/1998 - "Diminished kidney function and nephrocalcinosis in rats fed a magnesium-deficient diet." 08/01/1998 - "Effect of dietary magnesium level on nephrocalcinosis and growth in rats."
4.	pamidronate (APD)FDA LinkGeneric 01/01/2006 - "To prevent nephrocalcinosis, pamidronate might be considered as first line treatment for severe hypercalcemia in SCFN." 09/01/2001 - "The increased potency of zoledronic acid allowed us to give one-tenth the dose of pamidronate, with increased therapeutic efficacy and no evidence of nephrocalcinosis." 09/01/2001 - "Nephrocalcinosis was identified in 14 of 20 kidneys of rabbits infused with pamidronate, but was not detected in the 20 kidneys of those rabbits infused with zoledronic acid. "
5.	PhosphorusIBA 07/01/1991 - "Phosphorus-induced nephrocalcinosis in female rats: a study on regression and clinical abnormalities." 01/01/1974 - "[Possible role of excessive phosphorus consumption in the pathogenesis of nephrocalcinosis (an experimental study)]." 05/01/2015 - "Serum phosphorus level, but not nephrocalcinosis predicted renal death, independent of renal function. " 11/01/2007 - "High-phosphorus (P) diet induces nephrocalcinosis in rats; however, the mechanism for onset of this disorder is unclear. " 04/01/2001 - "Nephrocalcinosis, as confirmed by a histological examination, was apparent in all rats fed on the high-phosphorus diet, and this condition was more severe in those rats fed on K5P3O10 than in those fed on KH2PO4. "
6.	Vitamin DFDA LinkGeneric 03/01/1960 - "A comparative cytochemical and cytologic study of vitamin D induced nephrocalcinosis." 08/01/2015 - "In order to expedite the identification of this rare disorder and improve therapies to avoid its progression to nephrocalcinosis, this editorial updates the current knowledge on the frequency of CYP24A1-inactivating mutations, the features of their early clinical presentation and progression, and the pathophysiology of vitamin D activation in health and in granulomatous disorders that may help improve current treatment. " 05/01/2014 - "Diagnosis: Nephrocalcinosis secondary to exogenous vitamin D intoxication." 11/01/2007 - "Nephrocalcinosis seems correlated to chronic administration while cardiovascular disorders are more likely associated with massive acute vitamin D administration, severe dysrhythmia being rare in children in this context." 07/01/2001 - "All patients had been treated previously with vitamin D and oral phosphate and had radiologic evidence of nephrocalcinosis. "
7.	Calcium OxalateIBA 11/01/2015 - "Nephrocalcinosis can occur in calcium oxalate stone formers but the quantity and frequency of nephrocalcinosis in this group are dramatically less." 09/01/2007 - "The incidence of tubular calcium oxalate nephrocalcinosis could be underestimated due to the loss of crystals during tissue processing for routine histology. " 06/01/2006 - "Continuous infusion of oxalate by minipumps induces calcium oxalate nephrocalcinosis." 11/01/1987 - "[Experimental calcium oxalate nephrocalcinosis. " 04/01/1960 - "I. Clinical and pathologic findings in a patient with calcium oxalate nephrocalcinosis."
8.	Primary hyperoxaluria type 1IBA 12/01/2010 - "Cortical nephrocalcinosis in an infant caused by primary hyperoxaluria type 1." 08/01/1996 - "Although nephrocalcinosis is a classical finding in primary hyperoxaluria type 1 (PH 1) associated with a poor renal survival it is exceptional in patients with PH type 2 (PH 2), characterized by a more favorable outcome. " 11/01/2010 - "Excellent renal function and reversal of nephrocalcinosis 8 years after isolated liver transplantation in an infant with primary hyperoxaluria type 1." 09/01/2015 - "Primary Hyperoxaluria Type 1: A Cause for Infantile Renal Failure and Massive Nephrocalcinosis." 07/01/2011 - "Therefore primary hyperoxaluria type 1 is responsible for hyperoxaluria leading to aggressive stone formation and nephrocalcinosis. "
9.	Phenobarbital (Luminal)FDA Link 10/01/2005 - "Experimental studies revealed that crystal retention in the distal nephron, a process that may lead to nephrocalcinosis, is limited to proliferating/regenerating tubular cells expressing hyaluronan and osteopontin at their luminal surface. " 01/01/1998 - "We investigated the anticalcification efficacy of oral potassium citrate versus the combined administration of this drug and magnesium citrate in the magnesium-deficient rat developing corticomedullary nephrocalcinosis and luminal microliths in the long term. "
10.	Amifostine (Ethyol)FDA LinkGeneric 02/01/1987 - "This nephrocalcinosis was markedly reduced by WR-2721 treatment. " 02/01/1987 - "In conclusion, the present study suggests that chronic treatment with WR-2721, a potent inhibitor of PTH secretion, may be effective for preventing the deleterious consequences of hyperparathyroidism, such as nephrocalcinosis." 02/01/1987 - "Prevention of parathyroid hormone-dependent nephrocalcinosis by chronic administration of the organic phosphorothioate WR-2721." 02/01/1987 - "WR-2721 failed to reduce the nephrocalcinosis induced by 1,25 dihydroxyvitamin D3 intoxication in TPTX rats fed the normal Ca-normal phosphorus diet. "

Therapies and Procedures

1.	Transplants (Transplant) 08/01/2008 - "In patients with this complication, calcimimetics may help to improve bone health both by suppressing bone turnover and demineralization and may retard or prevent nephrocalcinosis of the graft. " 07/01/2014 - "In conclusion, the disease was characterized by an autosomal recessive compound heterozygous status and, after five years of donation the renal graft function remained stable without recurrence of metabolic disturbances or nephrocalcinosis. " 10/01/2005 - "Preterm neonates and renal transplant patients frequently develop nephrocalcinosis. " 09/01/1999 - "Repeated graft sonography showed no nephrocalcinosis, but mild oxalate deposits are noted on renal biopsy. " 10/01/2005 - "Rapidly developing nephrocalcinosis in a patient with end-stage liver disease who received a domino liver transplant from a patient with known congenital oxalosis."
2.	Drug Therapy (Chemotherapy) 09/01/1983 - "Nephrocalcinosis due to hyperphosphataemia with hypocalcaemia is a rare cause of ARF during chemotherapy of ALL. " 05/01/1992 - "In all 5 infants with nephrocalcinosis, renal calculi decreased and urine Ca/Cr improved after drug therapy was discontinued. " 06/01/1984 - "The authors report a documented case of hyperphosphatemia-induced nephrocalcinosis after chemotherapy of an acute lymphoblastic leukemia (ALL). " 06/01/2002 - "The potential causes of progressive and severe intrarenal fibrosis, infundibular stenosis and nephrocalcinosis, and renal cysts in this patient may include abnormal renal development secondary to Beckwith-Wiedemann syndrome itself, radiation or chemotherapy damage, or a combination."
3.	Kidney Transplantation 07/01/2014 - "To report a case of kidney transplantation father to daughter in a familial occurrence of severe bilateral nephrocalcinosis associated with ocular impairment in a non-consanguineous Brazilian family, in which two daughters had nephrocalcinosis and severe retinopathy. " 05/01/2005 - "Hypocitraturia as a risk factor for nephrocalcinosis after kidney transplantation." 01/01/1978 - "A renal transplantation performed in one of the patients failed because of the formation of nephrocalcinosis." 06/01/2003 - "Hyperphosphaturia after kidney transplantation in syngeneic rats: effects on nephrocalcinosis and bone metabolism?" 01/01/1989 - "Recurrence of nephrocalcinosis after renal transplantation in an adult patient with primary hyperoxaluria type I."
4.	Total Parenteral Nutrition 11/01/1998 - "Oxalate has been implicated in the etiology of nephrocalcinosis in premature infants as well as in the formation of insoluble precipitates in total parenteral nutrition (TPN) intravenous tubing. " 07/01/2003 - "The aim of this study was to evaluate prospectively the influence of nutrition on certain factors which may inhibit or promote nephrocalcinosis in two groups of preterm infants, receiving total parenteral nutrition (TPN) and special preterm milk formula respectively, but not furosemide. " 11/01/1989 - "In VLBW infants who receive total parenteral nutrition, elevated urinary oxalate concentrations may develop and may be a factor in the pathogenesis of nephrocalcinosis in these infants." 11/01/2001 - "In addition, babies with nephrocalcinosis had a lower intake of fluid, calcium, and phosphate, longer duration of total parenteral nutrition, and higher urinary oxalate/creatinine and urate/creatinine ratios than infants who did not have the condition. "
5.	Neonatal Intensive Care 03/01/2014 - "The objective of this study was to determine the incidence and risk factors of nephrocalcinosis (NC) in pre-term neonates in the neonatal intensive care unit (NICU) at the Al-Minya University, Egypt. "