Paraneoplastic Endocrine Syndromes

Syndromes resulting from inappropriate production of HORMONES or hormone-like materials by NEOPLASMS in non-endocrine tissues or not by the usual ENDOCRINE GLANDS. Such hormone outputs are called ectopic hormone (HORMONES, ECTOPIC) secretion.

Also Known As:

Ectopic Hormone Syndrome; Endocrine Syndrome, Paraneoplastic; Paraneoplastic Endocrine Syndrome; Syndrome, Ectopic Hormone; Syndrome, Paraneoplastic Endocrine; Syndromes, Ectopic Hormone; Syndromes, Paraneoplastic Endocrine; Ectopic Hormone Syndromes

Networked: 15 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Neoplasms (Cancer)
2.	Hypercalcemia (Milk Alkali Syndrome)
3.	Paraneoplastic Syndromes (Paraneoplastic Syndrome)
4.	Inappropriate ADH Syndrome (SIADH)
5.	Diabetes Mellitus

Experts

1.	Takahashi, Yutaka: 2 articles (06/2023 - 01/2022)
2.	Chorny, Joseph A: 1 article (01/2024)
3.	Orrego, John J: 1 article (01/2024)
4.	Igaz, Péter: 1 article (06/2023)
5.	Henzen, Christoph: 1 article (11/2018)
6.	Ahn, Joong Hyun: 1 article (10/2015)
7.	Jeong, Chaiho: 1 article (10/2015)
8.	Kang, Hye Seon: 1 article (10/2015)
9.	Kim, Ju Sang: 1 article (10/2015)
10.	Lee, Hwa Young: 1 article (10/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Paraneoplastic Endocrine Syndromes:

1.	Adrenocorticotropic Hormone (ACTH)FDA Link 09/01/1984 - "Ectopic adrenocorticotropic hormone (ACTH) syndrome was the first ectopic hormone syndrome to be described. " 01/01/1982 - "Ectopic hormone syndromes associated with tumors in childhood are discussed as well as the possible mechanism involved in the ectopic production of ACTH." 10/01/2015 - "Small cell lung cancer (SCLC), which originated from neuroendocrine tissue, can develop into paraneoplastic endocrine syndromes, such as Cushing syndrome, because of an inappropriate secretion of ectopic adrenocorticotropic hormone (ACTH). " 06/01/1986 - "Paraneoplastic endocrine syndromes frequently observed are Cushing's syndrome due to ectopic production of ACTH, SIADH due to ectopic production of ADH, hyper-calcemia, hypoglycemia and so on. " 06/28/2023 - "In particular, paraneoplastic endocrine syndromes are mainly caused by ectopic hormone production by the tumor such as PTHrP in humoral hypercalcemia in malignancy and ACTH in ectopic ACTH syndrome. "
2.	Hormones (Hormone)IBA 06/13/2023 - "Hormone-related paraneoplastic syndromes are termed paraneoplastic endocrine syndromes. " 01/01/2003 - "The paraneoplastic endocrine syndromes ("ectopic" or "inappropriate" hormone production) comprise a wide array of symptom complexes associated with malignant or less commonly benign neoplasms. " 06/01/1986 - "Paraneoplastic endocrine syndromes should be distinguished from hormone production by benign cells, hormone production by a malignancy of an endocrine organ or alterations in hormone production being due to infiltration into the endocrine organ by a primary tumor. " 01/01/2022 - "In addition, some of malignant tumors ectopically produce hormones and lead to a clinically relevant ectopic hormone syndrome as an endocrine paraneoplastic syndrome. "
3.	Parathyroid Hormone-Related ProteinIBA 01/01/2003 - "Hypercalcemia, the most common paraneoplastic endocrine syndrome, may be due to the systemic release of parathyroid hormone-related protein (PTHrP), factors that may be produced locally (cytokines), or by a combination of these mechanisms. " 06/28/2023 - "In particular, paraneoplastic endocrine syndromes are mainly caused by ectopic hormone production by the tumor such as PTHrP in humoral hypercalcemia in malignancy and ACTH in ectopic ACTH syndrome. "
4.	Ectopic HormonesIBA 11/01/2018 - "Paraneoplastic endocrine syndromes are caused by ectopic hormone production by malignant tumor cells. " 06/28/2023 - "In particular, paraneoplastic endocrine syndromes are mainly caused by ectopic hormone production by the tumor such as PTHrP in humoral hypercalcemia in malignancy and ACTH in ectopic ACTH syndrome. "
5.	CytokinesIBA 01/01/2003 - "Hypercalcemia, the most common paraneoplastic endocrine syndrome, may be due to the systemic release of parathyroid hormone-related protein (PTHrP), factors that may be produced locally (cytokines), or by a combination of these mechanisms. "
6.	Vasopressins (Vasopressin)IBA 06/01/1979 - "Inappropriate secretion of antidiuretic hormone or Schwartz-Bartter syndrome is considered to be a paraneoplastic endocrine syndrome, most frequently associated with a small cell anaplastic carcinoma of the lung. "
7.	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 03/01/1975 - "Human molar thyrotrophin can be produced by trophoblastic tumours in both sexes and thyroid-stimulating factors have been reported to be released by malignant tumours of the gut and by bronchogenic carcinomas, although this is one of the rarest of the ectopic hormone syndromes."
8.	Thyroid HormonesIBA 09/01/1992 - "Potential indications include ectopic hormone syndromes, medullary thyroid carcinomas, pituitary resistance to thyroid hormones, tall stature children, diabetes mellitus and diabetic complications, polycystic ovary syndrome, and Graves' ophthalmopathy. "
9.	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 10/01/1983 - "Somatostatin analogs with dissociated actions could be promising for the treatment of diseases such as acromegaly, diabetes mellitus and some ectopic hormone syndromes."
10.	IodineIBA 01/01/2024 - "An ultrarare case of a middle-aged man with heavily treated broadly metastatic radioactive iodine-refractory widely invasive Hürthle cell carcinoma (HCC) of the thyroid with two synchronous paraneoplastic endocrine syndromes, T3 thyrotoxicosis and hypercalcemia of malignancy, is discussed here. "