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Multiple Primary Neoplasms

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Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.

Also Known As:

Neoplasms, Multiple Primary; Multiple Primary Neoplasms, Synchronous; Synchronous Multiple Primary Neoplasms; Synchronous Neoplasms; Multiple Primary Neoplasm; Neoplasm, Multiple Primary; Neoplasm, Synchronous; Primary Neoplasm, Multiple; Primary Neoplasms, Multiple; Synchronous Neoplasm; Neoplasms, Synchronous; Neoplasms, Synchronous Multiple Primary

Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Neoplasms: 649836
- Multiple Primary Neoplasms: 22
  - Multiple Endocrine Neoplasia: 485
  - Multiple Hamartoma Syndrome: 185

Related Diseases

1.	Neoplasms (Cancer)
2.	Squamous Cell Carcinoma (Epidermoid Carcinoma)
3.	Colorectal Neoplasms (Colorectal Cancer)
4.	Breast Neoplasms (Breast Cancer)
5.	Malignant Fibrous Histiocytoma

Experts

1.	Osorio, Irene: 1 article (01/2014)
2.	Urioste, Miguel: 1 article (01/2014)
3.	Rueda, Daniel: 1 article (01/2014)
4.	Masarykova, A: 1 article (01/2014)
5.	Benítez, Javier: 1 article (01/2014)
6.	Alegre, Cristina: 1 article (01/2014)
7.	Canal, Alicia: 1 article (01/2014)
8.	Pobijakova, M: 1 article (01/2014)
9.	Álvaro, Edurne: 1 article (01/2014)
10.	Rivera, Bárbara: 1 article (01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Primary Neoplasms:

1.	CytokinesIBA 04/01/2004 - "Prospective follow-up of older cancer patients, involving measurement of circulating cytokines, whose concentration increases with age, and study of the genotype of older individuals, may provide new information about whether certain older individuals are at increased risk for multiple primary neoplasms."
2.	Mitomycin (Mitomycin-C)FDA LinkGeneric 09/01/1984 - "Irradiation therapy raised the occurrence of multiple primary neoplasms 1.28 fold, and Mitomycin C (40 mg) had no effect on the occurrence of neoplasms during a 10-year observation period." 04/01/1985 - "The influence of family history of cancer, irradiation and anticancer medication (mitomycin C), on the occurrence of multiple primary neoplasms with breast cancer--statistical analysis by the person-year method." 09/01/1984 - "The influence of family history, irradiation and anti-cancer drug (Mitomycin C) on the occurrence of multiple primary neoplasms was analysed using the person-year method in 1359 Japanese breast carcinoma patients. " 09/01/1984 - "[Influence of family history, irradiation and anti-cancer drug (mitomycin C) on the occurrence of multiple primary neoplasms in breast carcinoma patients]." 04/01/1985 - "The influence of family history of cancer, radiation therapy and anticancer drug therapy (mitomycin C) on the occurrence of multiple primary neoplasms, following treatment of a first primary cancer of the breast, was analyzed by the person-year method in 1,359 patients, in Japan. "
3.	DNA (Deoxyribonucleic Acid)IBA 11/15/1990 - "Although the interrelationships between these multiple synchronous neoplasms are not entirely clear, the DNA analysis suggests that the occurrence of nondiploid stemlines and heterogeneous DNA content may parallel both tumor growth and more aggressive behavior."
4.	Carbon MonoxideIBA 11/01/2007 - "We report a case of unusual co-existence of multiple primary neoplasms of female genital tract. "
5.	Blood Group Antigens (Blood Groups)IBA 09/15/1983 - "[Distribution of ABO blood groups in women with multiple primary neoplasms - cancer of the breast and cervix uteri]."
6.	BariumIBA 06/01/1992 - "In 57% of patients, the presence of synchronous neoplasms was diagnosed preoperatively by colonoscopy and/or barium enema, in 38% peroperatively and in 5% postoperatively. "
7.	AsbestosIBA 05/01/1991 - "A brief discussion of multiple primary neoplasms associated with exposure to asbestos is also presented."
8.	glutathione S-transferase M1IBA 01/01/2004 - "Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco."
9.	tebufenozide (Mimic)IBA 08/01/2005 - "Sites of pathologic (18)F-FDG uptake should be confirmed by dedicated additional investigations before treatment, because synchronous neoplasms may mimic metastases."
10.	Calcibiotic Root Canal SealerIBA 01/01/2014 - "Early-onset microsatellite-stable/CIMP-high CRCs were more frequently mucinous and right sided than elderly cases, with a high incidence of Lynch syndrome neoplasms; early-onset microsatellite stable/CIMP-low/0 differed from elderly cases in location, stages, incidence of multiple primary neoplasms, and the familial component. "

Therapies and Procedures

1.	Radiotherapy 04/01/1986 - "Chemotherapy-associated multiple primary neoplasms seemed to appear more quickly than radiotherapy-associated multiple primary neoplasms. " 01/01/2014 - " words: malignant fibrous histiocytoma - radiotherapy - upper extremity - neoplasms - multiple primary." 01/01/2013 - "We present a patient with a history of endometrial cancer who, 3 years after surgery and radiotherapy, developed synchronous neoplasms of the breast, colon and rectum. " 04/01/1986 - "The presumptive factors for multiple primary neoplasms suggested radiotherapy-associated cancers in 30%, radiochemotherapy-associated in 13%, chemotherapy-associated in 34%, and genetic factor-related in 36% of cases. " 01/01/2004 - "In this study conducted amongst Indian male tobacco users with upper aero-digestive tract (UADT) squamous carcinoma, 30 patients with multiple primary neoplasms (MPN) were compared with 28 age and sex matched patients with a single primary neoplasm (SPN) for various environmental factors (form of tobacco use, alcohol, radiotherapy for index cancer) and genetic parameters (family history of UADT cancers and GSTT1/GSTM1 genotype). "
2.	Drug Therapy (Chemotherapy) 04/01/1986 - "Chemotherapy-associated multiple primary neoplasms seemed to appear more quickly than radiotherapy-associated multiple primary neoplasms. " 09/09/2009 - "Multiple primary neoplasms occur either by hazard or in the context of hereditary cancer syndromes, after chronic toxic exposition, in immunodeficiency or as secondary malignancies after radio- and/or chemotherapy. " 04/01/1986 - "The presumptive factors for multiple primary neoplasms suggested radiotherapy-associated cancers in 30%, radiochemotherapy-associated in 13%, chemotherapy-associated in 34%, and genetic factor-related in 36% of cases. " 04/01/1985 - "The influence of family history of cancer, radiation therapy and anticancer drug therapy (mitomycin C) on the occurrence of multiple primary neoplasms, following treatment of a first primary cancer of the breast, was analyzed by the person-year method in 1,359 patients, in Japan. "
3.	Colectomy 06/01/2007 - "Subtotal colectomy is recommended for patients with ischemic lesions and serosal tears on the cecum, and when there is a synchronous neoplasm in the proximal colon." 12/01/1995 - "Segmental resection following intraoperative irrigation is the preferred option except when there is caecal perforation or if synchronous neoplasms are present in the colon, when subtotal colectomy is more appropriate."
4.	Colonoscopes 03/01/1985 - "To find and eradicate synchronous neoplasms, colonoscopy was performed before and after resectional surgery in 50 patients with "occluding colorectal cancer," defined as encroachment of the lumen by tumor to a degree that prevented passage of a colonoscope. "
5.	Stents 05/01/2013 - "Preoperative colonoscopy for detection of synchronous neoplasms after insertion of self-expandable metal stents in occlusive colorectal cancer: comparison of covered and uncovered stents."