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Nefopam (Ajan)

Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)

Also Known As:

Ajan; 3M Brand of Nefopam Hydrochloride; Acupan; Biocodex Brand of Nefopam Hydrochloride; Fenazoxine; Krewel Brand of Nefopam Hydrochloride; Nefopam Hydrochloride; Silentan Nefopam; Hydrochloride, Nefopam; Nefopam, Silentan; 1H-2,5-Benzoxazocine, 3,4,5,6-tetrahydro-5-methyl-1-phenyl-

Networked: 132 relevant articles (20 outcomes, 22 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Azocines
    - Oxazocines
      - Nefopam: 132
        desmethyl-nefopam
        N-desmethylnefopam

Experts

1.	Girard, Philippe: 5 articles (03/2011 - 04/2004)
2.	Pansart, Yannick: 5 articles (03/2011 - 04/2004)
3.	Gillardin, Jean-Marie: 5 articles (04/2008 - 04/2004)
4.	Coppé, Marie-Claude: 4 articles (03/2011 - 10/2004)
5.	Sessler, Daniel I: 3 articles (07/2014 - 01/2005)
6.	Alfonsi, Pascal: 3 articles (07/2014 - 01/2005)
7.	Guignard, Bruno: 3 articles (07/2014 - 01/2005)
8.	Chauvin, Marcel: 3 articles (07/2014 - 01/2005)
9.	Verniers, Danielle: 3 articles (04/2008 - 10/2004)
10.	Benhamou, Dan: 3 articles (11/2007 - 02/2004)

Related Diseases

1.	Pain (Aches) 06/01/2014 - "At the slower rate of infusion (60 ml/h) of the 1.5 mg/ml nefopam solution, injection pain intensity was attenuated to a significantly greater degree than at the faster rates." 09/01/2012 - "Pooled analysis showed a significant reduction in pain levels favoring nefopam over placebo after 2 weeks [weighted mean difference -21.2, 95% CI -35.6 to -6.7; number needed to treat (NNT) 2, 95% CI 1.4 to 9.5]. " 04/01/1980 - "Although a few patients with chronic pain have received nefopam for several weeks, further studies are needed to clarify its continued effectiveness and safety when used over long periods. " 09/01/2015 - "Pain intensity scores at rest and on coughing were significantly lower in the nefopam group throughout the first 12 and 48 h after operation, respectively. " 07/01/2015 - "Nefopam is a non-opiate analgesic commonly used for the treatment of moderate to severe pain. "
2.	Postoperative Pain 01/01/2009 - "In the absence of evidence of efficacy for oral nefopam in acute postoperative pain, its use in this indication is not justified. " 01/01/2009 - "To assess the efficacy of single dose oral nefopam in acute postoperative pain, and any associated adverse events. " 01/01/1988 - "[Evaluation of the analgesic efficacy of nefopam in postoperative pain]." 01/01/2009 - "No included studies were identified after examining in detail thirteen studies on oral nefopam in participants with established postoperative pain. " 01/01/2009 - "Randomised, double-blind, placebo-controlled clinical trials of oral nefopam for relief of acute postoperative pain in adults. "
3.	Neuralgia (Stump Neuralgia) 08/01/2015 - "The present study investigates the mechanical antiallodynic effect of nefopam using immunohistochemical study and western blot analysis in a rat neuropathic pain model. " 08/01/2015 - "Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model." 10/01/2014 - "However, the effect of nefopam on diabetic neuropathic pain is unclear. " 07/01/2014 - "The potential role of intrathecal nefopam in the management of neuropathic pain." 04/30/2014 - "Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats."
4.	Neoplasms (Cancer) 01/01/2014 - "[Postoperative analgesia with nefopam and non-steroidal anti-inflammatory drugs in patients after surgery for tumors of head and neck]." 01/01/2012 - "Nefopam caused a 45% decline in tumor number, 33% decline in tumor volume, and a 40% decline in scar size when tested in mice. " 03/01/1999 - "Oxadol (nefopam hydrochloride), a central analgesic, was used for postoperative pain relief in patients operated on the abdominal and pelvic organs for cancer. " 12/01/1977 - "The efficacy of nefopam, a novel analgesic agent, was compared to pentazocine in a double blind study in 40 cancer patients with chronic pain. " 07/01/1976 - "Open study of the analgesic effects of nefopam hydrochloride (Acupan) on cancer patients with pain."
5.	Hyperalgesia 10/01/2014 - "Pretreatment with nefopam significantly inhibited STZ-induced mechanical and cold allodynia, but not thermal hyperalgesia. " 06/01/2013 - "Effects of nefopam on early postoperative hyperalgesia after cardiac surgery." 06/01/2013 - "Nefopam administered during the perioperative period slightly reduced acute hyperalgesia after cardiac surgery, but this was not associated with improved analgesic efficacy." 06/01/2013 - "The purpose of this randomized, double-blind placebo-controlled study was to evaluate the effect of nefopam, a centrally acting antinociceptive compound, on the development of hyperalgesia after sternotomy. " 08/01/2015 - "In conclusion, intrathecal nefopam reduced mechanical allodynia in a rat neuropathic pain model. "

Related Drugs and Biologics

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2.	Morphine (MS Contin)
3.	Ketoprofen (Orudis)
4.	Capsaicin (Zostrix)
5.	Acetaminophen (Paracetamol)
6.	Diclofenac (SR 38)
7.	N-Methylaspartate (NMDA)
8.	Pentazocine (Talwin)
9.	Aspirin (Acetylsalicylic Acid)
10.	Tilidine

Related Therapies and Procedures

1.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
2.	Kidney Transplantation
3.	Perioperative Period
4.	Rewarming
5.	Ligation