Necrobiosis Lipoidica

A degenerative disease of the dermal connective tissue characterized by the development of erythematous papules or nodules in the pretibial area. The papules form plaques covered with telangiectatic vessels. More than half of the affected patients have diabetes.

Also Known As:

Networked: 173 relevant articles (13 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris)
2.	Lipodystrophy
3.	Telangiectasis (Telangiectasia)
4.	Melanoma (Melanoma, Malignant)
5.	Hirsutism

Experts

1.	Borgia, Francesco: 2 articles (07/2015 - 12/2014)
2.	Cannavò, Serafinella P: 2 articles (07/2015 - 12/2014)
3.	Dissemond, J: 2 articles (07/2013 - 08/2007)
4.	Körber, A: 2 articles (07/2013 - 08/2007)
5.	Harth, W: 2 articles (06/2011 - 04/2004)
6.	Hsu, Sylvia: 2 articles (07/2010 - 01/2009)
7.	Boyd, Alan S: 2 articles (11/2007 - 06/2007)
8.	Gambichler, T: 2 articles (10/2005 - 01/2003)
9.	Kreuter, A: 2 articles (10/2005 - 01/2003)
10.	Altmeyer, P: 2 articles (10/2005 - 01/2003)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Necrobiosis Lipoidica:

1.	Cyclosporine (Ciclosporin)FDA LinkGeneric 08/01/2007 - "[Successful therapy of ulcerated necrobiosis lipoidica non diabeticorum with cyclosporine A]." 12/01/2013 - "Juvenile ulcerated necrobiosis lipoidica successfully treated with oral cyclosporin A." 08/01/2007 - "Based on this case, we discuss the role of cyclosporine A in patients with necrobiosis lipoidica in the context of the disease etiology." 08/01/2007 - "We report on a 68-year-old patient with an 18 year history of ulcerated necrobiosis lipoidica non diabeticorum of both lower limbs, which responded to systemic cyclosporine A. " 05/01/2004 - "There have been four previous case reports of healing of treatment-resistant ulcerating necrobiosis lipoidica with cyclosporin."
2.	Pentoxifylline (Trental)FDA LinkGeneric 01/01/1993 - "Ulcerating necrobiosis lipoidica effectively treated with pentoxifylline." 01/01/1989 - "Rheologic parameters of the blood were examined in 17 patients with necrobiosis lipoidica before and over the course of trental (pentoxyphyllin) therapy. " 08/01/1987 - "Pentoxifylline for necrobiosis lipoidica diabeticorum." 01/01/1994 - "Chronic balanitis with palisading granuloma: an atypical genital localization of necrobiosis lipoidica responsive to pentoxifylline." 03/01/1997 - "Necrobiosis lipoidica often fails to respond adequately to therapy with topical and intralesional corticosteroids, or to systemic medications like niacinamide and pentoxifylline (Trental). "
3.	FumaratesIBA 01/01/2003 - "Clearance of necrobiosis lipoidica with fumaric acid esters." 10/01/2005 - "Fumaric acid esters in necrobiosis lipoidica: results of a prospective noncontrolled study." 01/01/2010 - "Fumaric acid esters in severe ulcerative necrobiosis lipoidica: a case report and evaluation of current therapies."
4.	Insulin (Novolin)FDA Link 12/01/1999 - "A 23-year-old woman with long-standing insulin dependent diabetes presented with necrobiosis lipoidica. " 01/06/1996 - "A young patient with insulin-dependent diabetes had a severe invalidating ulcerated necrobiosis lipoidica. " 11/15/1979 - "For the judgment of the peripheral blood supply 16 insulin-dependent diabetics with necrobiosis lipoidica at the lower extremities were compared with 15 insulin-dependent diabetics without necrobiosis lipoidica. " 12/14/1956 - "[Necrobiosis lipoidica as allergic skin reaction after insulin administration]." 01/01/2007 - "We report the ambulatory outpatient management of an insulin-dependent diabetic with ulcerated necrobiosis lipoidica complicated by activated protein C resistance."
5.	infliximab (Remicade)FDA Link 01/01/2003 - "Infliximab: a promising new treatment option for ulcerated necrobiosis lipoidica." 09/01/2011 - "Treatment of pre-ulcerative necrobiosis lipoidica with infliximab." 04/01/2009 - "Treatment of refractory ulcerative necrobiosis lipoidica diabeticorum with infliximab: report of a case." 01/01/2011 - "Intralesional infliximab in noninfectious cutaneous granulomas: three cases of necrobiosis lipoidica." 03/01/2005 - "Infliximab may be an additional option in the treatment of recalcitrant forms of GA as well as in other chronic granulomatous skin disorders, such as sarcoidosis and necrobiosis lipoidica."
6.	Erythema elevatum diutinumIBA 01/01/1993 - "This drug has shown promising results in the treatment of many dermatologic disorders including necrobiosis lipoidica diabeticorum, leukocytoclastic vasculitis and Raynaud's phenomenon. " 01/01/1969 - "[Diabetic necrobiosis lipoidica with an aspect of erythema elevatum diutinum]." 01/01/1959 - "[Erythema elevatum diutinum, granuloma annulare, necrobiosis lipoidica & granulomatosis disciformis Gottron-Miescher; a comparative study on their incidence]." 04/01/1979 - "[Dermatoses in scar tissue: necrobiosis lipoidica diabeticorum, erythema elevatum diutinum, pretibial myxedema, anetoderma, etc]."
7.	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 04/01/2010 - "Significant improvement in ulcerative necrobiosis lipoidica with hydroxychloroquine." 08/01/2010 - "[Ulcerated necrobiosis lipoidica: successful treatment with topical tacrolimus and hydroxychloroquine]."
8.	adalimumab (Humira)FDA Link 07/01/2013 - "Thus, adalimumab could represent promising new treatment option, especially for patients with otherwise therapy-refractory ulcerated necrobiosis lipoidica. " 07/01/2013 - "We present a new therapeutic option using adalimumab to treat refractory ulcerated necrobiosis lipoidica non diabeticorum. " 07/01/2013 - "[Successful treatment of a patient with ulcerated necrobiosis lipoidica non diabeticorum with adalimumab]." 01/01/2009 - "Treatment of necrobiosis lipoidica with etanercept and adalimumab."
9.	ThiazolidinedionesIBA 06/01/2007 - "Patients with such disparate conditions as psoriasis, hirsutism, melanoma, angiosarcoma, lipodystrophy, and necrobiosis lipoidica have benefited from the administration of thiazolidinediones. "
10.	Doxycycline (Vibramycin)FDA LinkGeneric 10/01/2011 - "[Significant improvement in ulcerative necrobiosis lipoidica with doxycycline]."

Therapies and Procedures

1.	Dye Lasers 09/01/2001 - "The purpose of this study was to evaluate the usefulness of pulsed dye laser (Candela SPTL, Irvine, MA, USA) in the treatment of an area of necrobiosis lipoidica of 4 cm in diameter on the anterior aspect of the leg in a non-diabetic patient. " 09/01/2001 - "Necrobiosis lipoidica diabeticorum treated with the pulsed dye laser." 12/01/1999 - "Pulsed dye laser treatment of necrobiosis lipoidica: report of a case." 09/01/2001 - "Pulsed dye laser may be a useful treatment for improving the telangiectasia and erythematous component of necrobiosis lipoidica."
2.	Transplants (Transplant) 09/01/2009 - "Does pancreas transplant in diabetic patients affect the evolution of necrobiosis lipoidica?" 11/01/1985 - "Necrobiosis lipoidica: treatment with porcine dressings, split-thickness skin grafts and pressure garments. " 03/01/1997 - "On the basis of unpublished work which showed a predominance of T helper cells in lesions of necrobiosis lipoidica, and recalling the case of a woman whose necrobiosis lipoidica improved after she was started on cyclosporine for a renal transplant, systemic cyclosporine was successfully used in the cases of two young women who had insulin-dependent diabetes and were disfigured by severe, ulcerating necrobiosis lipoidica on the anterior lower legs. "
3.	Aftercare (After-Treatment) 01/01/2011 - "Although this approach was clearly effective for necrobiosis lipoidica, the disease recurred several months after treatment interruption, raising the question of the need for maintenance therapy. " 01/01/1988 - "Skin blood flow was measured by the laser Doppler technique in lesional and clinically normal skin of 10 diabetic patients with necrobiosis lipoidica during and after treatment with 40 mg acetylsalicylic acid (ASA) daily. " 03/01/1989 - "In ten female patients with necrobiosis lipoidica diabeticorum (six who were diabetic and four who were not) platelet survival times were measured before and after treatment with aspirin and dipyridamole. "
4.	Bariatric Surgery 01/01/2013 - "Remission of ulcerated necrobiosis lipoidica diabeticorum after bariatric surgery." 01/01/2013 - "We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery."
5.	Photochemotherapy (Photodynamic Therapy) 12/01/2014 - "Ulcerative necrobiosis lipoidica successfully treated with photodynamic therapy: case report and literature review." 12/01/2013 - "Photodynamic therapy for necrobiosis lipoidica is an unpredictable option: three cases with different results." 05/01/2012 - "Case of necrobiosis lipoidica diabeticorum successfully treated by photodynamic therapy." 01/01/2009 - "Photodynamic therapy of necrobiosis lipoidica--a multicenter study of 18 patients." 12/01/2006 - "Successful treatment of necrobiosis lipoidica diabeticorum with photodynamic therapy."