4-Chloro-7-nitrobenzofurazan (4 Chloro 7 nitrobenzofurazan)

A benzofuran derivative used as a protein reagent since the terminal N-NBD-protein conjugate possesses interesting fluorescence and spectral properties. It has also been used as a covalent inhibitor of both beef heart mitochondrial ATPase and bacterial ATPase.

Also Known As:

4 Chloro 7 nitrobenzofurazan; 7-Chloro-4-nitrobenzofurazan; NBF-Cl; Nitrobenzoxadiazole Chloride; 7 Chloro 4 nitrobenzofurazan; Chloride, NBD; Chloride, Nitrobenzoxadiazole; NBF Cl; Chloronitrobenzoxadiazole; NBD Chloride; Benzofurazan, 4-chloro-7-nitro-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - Oxadiazoles: 146
        4-Chloro-7-nitrobenzofurazan: 3
        2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose: 43
        PC 16: 38
        6-deoxy-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminoglucose: 8
        1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine: 4
        7-nitrobenz-2-oxa-1,3-diazol-4-ylcholesterol: 4
        7-nitrobenzo-2-oxa-1,3-diazole chloride: 4
        N-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine: 4
        N-(7-nitro-2,1,3-benzoxadiazol-4-yl)phosphatidylserine: 2
        2,2,6-trimethyl-4-(4-nitrobenzo(1,2,5)oxadiazol-7-ylamino)-6-pentylpiperidine-1-oxyl: 1
        4-nitro-7-(3-aminopyrrolidin-1-yl)-2,1,3-benzoxadiazole: 1
        celecoxib-NBD: 1
        N-4-nitrobenzo-2-oxa-1,3-diazoleaminocaproyl sphingosylphosphorylcholine: 1
        (7-nitrobenzo(1,2,5)oxadiazol-4-yl)-(3-(dimethylamino)propyl)methylamine
        1,2-(oleoyl)-N-(6-((7-nitrobenz-2-oxa-1,3-diazo-4-yl)aminocaproyl))phosphatidylinositol
        1,2-(palmitoyl-NBD-aminocaproyl)phosphatidylethanolamine
        1-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-1-deoxyfructose
        1-oleoyl-2-((N-(7-(nitro)-2,1,3-benzoxadiazol-4-yl)amino)hexanoyl)glycero-3-phosphate
        1-oleoyl-2-((N-(7-nitro-2,1,3-benzoxadiazol-4-yl)amino)caproyl)phosphatidylserine
        1-oleoyl-2-(12-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)dodecanoyl)phosphatidylcholine
        1-oleoyl-2-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproylphosphatidylcholine
        1-oleoyl-2-hexanoyl-NBD-glycerol
        1-palmitoyl-2-(12-((7-nitro-2,1,3-benzoxadiazol-4-yl)amino)dodecanoyl)phosphatidylcholine
        1-palmitoyl-2-(12-((7-nitro-2-1,3-benzoxadiazol-4-yl)amino)dodecanoyl)glycero-3-phosphocholine
        1-palmitoyl-2-(6-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)caproyl)glycero-3-phosphoserine
        10,14-dihydroxy-9,11,13,13-tetramethyl-2-(1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl)-5-(7-nitro-benzo(1,2,5)oxadiazol-4-yl)-1-oxa-5-aza-cyclohexadecane-12,16-dione
        12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoic acid
        12-(N-methyl-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl))aminododecanoylsphingosyl-1-O-beta-glucoside
        12-N-methyl-7-nitrobenzo-2-oxa-1,3-diazolamino stearate
        2,5,7,8-tetramethylchroman-2-(9-(7-nitrobenz(1,2,5)oxadiazol-4-ylamino)nonyl)chroman-6-ol
        2-(6-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyl-1-hexadecanoylglycero-3-phosphocholine
        25-((7-chloro-4-nitrobenz-2-oxa-1,3-diazole)methylamino)-27-norcholesterol
        25-(N-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)methyl)amino)-27-norcholesterol
        3,7,11-trimethyl-12-(7-nitrobenzo(1,2,5)oxadiazo-4-ylamino)dodeca-2,6,10-trien-1-yl pyrophosphate
        3-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-3-toluene
        4-(N,N-dihexadecyl)amino-7-nitrobenz-2-oxa-1,3-diazole
        4-(N-(acetoxyethyl)-N-methylamino)-7-nitro-2,1,3-benzoxadiazole ubiquinone
        4-N-(4-N'-aminoethyl)piperazino-7-nitro-2,1,3-benzoxadiazole
        4-nitrobenzo-2-oxa-1,3-diazol-octreotide
        5-methyl 3-(6-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexyl 1,4-dihydro-2,6-dimethyl-4-(2-trifluoromethyl)phenyl-3,5-pyridinedicarboxylate
        7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole
        7-nitrobenz-2-oxa-1,3-diazol-4-yl dodecanoate
        7-nitrobenz-2-oxa-1,3-diazole desferrioxamine B
        7-nitrobenzoxadiazole-6-aminohexanoic acid
        acetyl-C16-ceramide-NBD
        alprenolol-NBD
        ASM 5-10
        ASM 5-67
        BD 623
        beta-(N-(7-nitro-2,1,3-benzoxadiazol-4-yl))alanyl-coenzyme A
        C12-NBD-ceramide
        CGP 12177-NBD
        N(1)-cholesterylcarbamoyl-N(8)-(4-nitrobenzo-2-oxa-1,3-diazole)-3,6-dioxaoctyl-1,8-diamine
        N(6)-(7-nitro-2,1,3-benzoxadiazol-4-yl)aminohexanoyl-1-phosphatidic acid
        N(alpha)-acetyl-N(epsilon)-4-(7-nitrobenzofurazanyl)lysyl-alanyl-alanine
        N,N,N-trimethyl-2-(methyl(7-nitrobenzo(c)(l,2,5)oxadiazol-4-yl)amino)ethanaminium
        N-(5-isothiocyanato-2-phenylindol-3-ylglyoxyl)-N'-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)-1,6-diaminohexane
        N-(6-N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminohexanoyl)-3-O-methylsphingosine
        N-(6-N--(7-nitrobenz-2-oxa-1,3-diazol-4-yl)aminohexanoyl)-1-O-methylsphingosine
        N-(7-nitro-2,1,3-benzoxadiazol-4-yl)dioleoylphosphatidylethanolamine
        N-(7-nitrobenz-2-oxa-1,3-diazole)-23,24-dinor-5-cholen-22-amine-3beta-ol
        N-(7-nitrobenzoxa-2,3-diazol-4-yl)hexadecylamine
        N-(N-(7-nitro-2,1,3-benzoxadiazol-4-yl)-epsilon-aminohexanoyl)sphingosylphosphorylcholine
        N-NBD-1,2-dilauroylphosphatidylethanolamine
        N1-(3-(dimethylamino)propyl)-N1,N3-dimethyl-N3-(7-nitro-benzo(1,2,5)oxadiazol-4-yl)-1,3-propanediamine
        Nalpha-nitroveratryloxycarbonylamino-N-epsilon-6-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)hexanoyllysine cyanomethyl ester
        NBD-5-acylcholine
        NBD-cerebroside
        NBD-colcemid
        NBD-galactosylceramide
        nitrobenzoxadiazolealanine
        pindolol-NBD
        SW120 compound

Experts

1.	Almahri, Albandary: 1 article (08/2021)

Related Diseases

1.	Allergic Contact Dermatitis 08/01/1991 - "Allergic contact dermatitis from 4-chloro-7-nitrobenzofurazan." 08/01/1991 - "A 30-year-old pharmacist suffered from acute allergic contact dermatitis due to 4-chloro-7-nitrobenzofurazan (NBD-Cl). "
2.	Hypercholesterolemia 10/01/1983 - "The thiol reagent NBD-chloride (4-chloro-7-nitro-benzo-2-oxo-1,3-diazole) was used to determine the amount and reactivity of SH-groups of Ca-ATPase of rat skeletal muscle sarcoplasmic reticulum during hypercholesterolemia. "
3.	Hirsutism 08/01/2021 - "Utility of 4-chloro-7-nitrobenzofurazan for spectrofluorimetric and spectrophotometric determinations of the anti-hirsutism agent (α-difluoromethylornithine) in pharmaceutical cream samples."

Related Drugs and Biologics

1.	Sulfhydryl Compounds (Thiols)
2.	Indicators and Reagents (Reagents)
3.	Eflornithine (Ornidyl)
4.	Adenosine Triphosphatases (ATPase)
5.	7-nitrobenzo-2-oxa-1,3-diazole chloride