Nasal Polyps (Nasal Polyp)

Focal accumulations of EDEMA fluid in the NASAL MUCOSA accompanied by HYPERPLASIA of the associated submucosal connective tissue. Polyps may be NEOPLASMS, foci of INFLAMMATION, degenerative lesions, or malformations.

Also Known As:

Networked: 1620 relevant articles (71 outcomes, 316 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sinusitis
2.	Cystic Fibrosis (Mucoviscidosis)
3.	Asthma (Bronchial Asthma)
4.	Polyps
5.	Rhinitis

Experts

1.	Bachert, Claus: 41 articles (01/2016 - 11/2003)
2.	Lee, Sang Hag: 28 articles (07/2015 - 02/2002)
3.	Lee, Heung-Man: 24 articles (11/2015 - 05/2006)
4.	Mullol, Joaquim: 23 articles (05/2015 - 05/2002)
5.	Bachert, C: 22 articles (02/2014 - 04/2001)
6.	Conley, David B: 20 articles (11/2015 - 10/2003)
7.	Grammer, Leslie C: 20 articles (11/2015 - 09/2004)
8.	Kern, Robert C: 19 articles (11/2015 - 10/2003)
9.	Lee, Seung Hoon: 19 articles (10/2014 - 03/2004)
10.	Holtappels, Gabriele: 18 articles (01/2016 - 03/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Nasal Polyps:

1.	SteroidsIBA 01/01/2008 - "Seven patients improved in their nasal polyps with topical steroids, six showed complete resolution. " 10/01/2013 - "Topical steroids are beneficial in the treatment of CRS with nasal polyps, but have not been shown to be effective in CRS without nasal polyps." 06/01/2011 - "Intranasal steroids are effective in preventing or delaying recurrence of nasal polyps. " 01/01/2004 - "This is particularly effective in reducing upper-airway mucosal congestion, nasal polyp formation, and systemic steroids." 02/01/2013 - "Oral steroids are commonly used in the management of chronic rhinosinusitis (CRS) with and without nasal polyps (CRSwNP and CRSsNP, respectively). "
2.	Budesonide (Pulmicort)FDA LinkGeneric 04/01/2001 - "Doses of budesonide aqueous nasal spray, 128 microg once daily, were found to be effective in the treatment of nasal polyps, and doses of budesonide aqueous nasal spray, 256 microg once daily, did not show any significant additional efficacy." 12/01/1990 - "The results demonstrate that topical nasal budesonide, 400 micrograms two times a day, is an effective treatment of nasal polyps." 02/01/1995 - "It is concluded that budesonide powder is useful in the treatment of nasal polyps." 12/01/2000 - "A randomized, double-blind, placebo-controlled trial was performed to assess the efficacy of once daily budesonide in patients with nasal polyps. " 05/01/1998 - "The aim of our study was to compare the efficacy of treatment of two formulations of budesonide with placebo on nasal polyps. "
3.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2005 - "Studies have suggested that topical corticosteroids are effective in the treatment of nasal polyps; however, this has yet to be confirmed in a large, robust clinical trial. " 09/01/2013 - "Intranasal and oral corticosteroids are widely used in the management of chronic rhinosinusitis with nasal polyps (CRSwNP). " 02/01/2013 - "Corticosteroids were effective in treating CRS with or without nasal polyps and reducing the chance of repeat endoscopic sinus surgery with manageable adverse effects and minimal systemic absorption. " 09/01/2015 - "Oral corticosteroids in the management of chronic rhinosinusitis with and without nasal polyps: Risks and benefits." 05/01/1996 - "Short-term treatment with systemic corticosteroids is an alternative method of inducing remission and controlling nasal polyps. "
4.	Clarithromycin (Biaxin)FDA LinkGeneric 02/01/2014 - "To evaluate the efficacy of clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis with nasal polyps (CRSwNP) or without nasal polyps (CRSsNP). " 01/01/2011 - "To evaluate the efficacy of long-term clarithromycin (CAM) treatment in adult Chinese patients suffering from chronic rhinosinusitis without nasal polyps (CRSnNP). " 12/01/2014 - "Preoperative clarithromycin administration postponed nasal polyp relapse after FESS. " 12/01/2014 - "Eighty nasal polyp patients (42 non-atopic and 38 atopic) were included in this prospective, non-placebo controlled investigation and randomized equally to either the combined clarithromycin-surgical or surgical group. " 03/01/2014 - "Low-dose clarithromycin has been recommended for the treatment of chronic rhinosinusitis without nasal polyps. "
5.	fluticasone (Cutivate)FDA LinkGeneric 07/01/2010 - "Impact of baseline nasal polyp size and previous surgery on efficacy of fluticasone delivered with a novel device: a subgroup analysis." 01/01/2008 - "Comparison of the efficacy of nasal drop and nasal spray applications of fluticasone propionate in nasal polyps." 09/01/2004 - "This double-blind placebo-controlled randomized study was performed in order to investigate whether fluticasone propionate aqueous nasal spray (FPANS) reduces the recurrence rate of nasal polyps and chronic rhinosinusitis during the first year after FESS. " 01/01/2005 - "Nasal polyps were obtained from 22 patients, before and after 4 weeks of local steroid treatment (fluticasone). " 11/01/2004 - "(2) The effects of Fluticasone propionate on nasal polyps may be related to changing the expression of AQP-5 to a degree. "
6.	Messenger RNA (mRNA)IBA 04/14/2015 - "The relative expression levels of mRNA expression of MUC5AC were significantly greater in patients of CRS with or without nasal polyps than in controls (1.861±0.718 and 1.562±0.428 vs 1.004±0.094, P<0.05). " 11/01/2013 - "The mRNA expressions of 5-LOX, 15-LOX-1, FPRL-1, and CysLT1R were significantly greater in nasal polyps than in inferior turbinates. " 08/01/2006 - "Significantly greater levels of PGDS mRNA and lesser levels of PGES mRNA were observed in the nasal polyps as compared with uncinate process mucosae, and an inverse correlation between PGDS and PGES expression was observed. " 07/01/2014 - "To study the expression of intedeukin-5 (IL-5) mRNA and protein in Nasal polyps and in the inferior turbinate, and to explore the relationship between the expression and the Clinical features. " 01/01/2014 - "In this study, we show that tissue MC in human nasal polyps express DP2 protein, and that human MC lines and primary cultured human MC express mRNA as well as protein of DP2. "
7.	Beclomethasone (Beclometasone)FDA Link 09/01/1976 - "As morphological studies did not reveal any sign of adverse effects, beclomethasone dipropionate may be regarded as a valuable drug in the treatment of nasal polyps. " 04/01/2001 - "Using May-Grünwald-Giemsa (MGG) method and immunohistochemical method, the protein expression of Bcl-x1 and Bcl-2 in eosinophils in nasal polyps from patients treated with beclomethasone dipropionate treatment and patients without any treatment was compared. " 04/01/2001 - "[The protein expression of Bcl-x1 and Bcl-2 in eosinophils in nasal polyps and the influence of beclomethasone dipropionate on the expression]." 01/01/1999 - "Topical treatment of nasal polyps with a beclomethasone dipropionate powder preparation." 06/01/1983 - "Intranasal beclomethasone in severe rhinosinusitis and nasal polyps."
8.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 06/01/2014 - "Aspirin desensitization: useful treatment for chronic rhinosinusitis with nasal polyps (CRSwNP) in aspirin-exacerbated respiratory disease (AERD)?" 09/01/2012 - "However, studies concerning survivin expression in chronic rhinosinusitis (CRS) with nasal polyps are rare and the specificity of the survivin expression in nasal polyps from individuals with aspirin-exacerbated respiratory disease (AERD) has not been investigated. " 05/01/2009 - "The purpose of this study was to apply protein microarray technology to the study of sinonasal tissue and to identify differential protein expression in nasal polyps from aspirin-sensitive (AS) versus aspirin-tolerant (AT) patients with chronic rhinosinusitis (CRS) and CRS with nasal polyps (CRSwNPs). " 01/01/2007 - "Our study revealed that nasal polyps of aspirin-sensitive patients were infiltrated with eosinophils and mast cells, Cys-LT(1) receptor proportions in these inflammatory cells were found to be higher and Cys-LT(1) receptor immunoreactivity in eosinophils and mast cells was increased." 02/01/1987 - "The findings of this study will help to explain biochemical basis of the pathogenesis of aspirin-sensitive nasal polyps and to develop better medical treatment for them."
9.	Immunoglobulin E (IgE)IBA 09/01/1996 - "Total and specific immunoglobulin E (IgE) are found in significantly greater concentration in nasal polyp tissue than in serum and tonsil tissue. " 07/01/2005 - "[Study on the association among total immunoglobulin E and eosinophil in nasal polyp]." 01/01/1986 - "The present study suggests that mast cell degranulation plays an important role in the formation of nasal polyps, but it may not only be an IgE-dependent mechanism. " 09/01/1975 - "Immunofluorescence studies on renal tissue, tonsils, adenoids, nasal polyps, and skin of atopic and nonatopic patients, with special reference to IgE." 11/01/2014 - "In conclusion, IgE antibody could be locally produced in the nasal polyp tissue while not detectable in the serum."
10.	Erythromycin (Erycette)FDA LinkGeneric 06/01/1994 - "Therefore, the present study was carried out to determine the correlation between the clinical efficacy of EM therapy and the histopathological features of the ethmoidal mucosa and nasal polyps of patients treated with erythromycin. " 05/01/2015 - "The subgroup of patients without nasal polyps in the erythromycin group showed a tendency to improvement in some secondary outcome criteria. " 01/01/2007 - "To study the effect of erythromycin on apoptosis in epithelial cell and investigate the significance of epithelial cell apoptosis in nasal polyps forming. " 07/01/2006 - "To study the effect of erythromycin on apoptosis and expression of Bax and Bcl-2 of epithelial cell in nasal polyps. " 12/01/2003 - "To study the expression of apoptotic gene in nasal polyps and the possible effect of erythromycin on it. "

Therapies and Procedures

1.	Oral Administration 03/01/2012 - "We present a patient with chronic rhinosinusitis with nasal polyps who exhibited relief of nasal obstruction and nasal discharge and improvement in the sense of smell following oral administration of 150 mg of aspirin daily. " 12/01/2001 - "Four weeks after surgery, nasal polyps recurred, but his condition was improved by oral administration of steroids and nebulizer treatment with steroids and fluconazole. "
2.	Aftercare (After-Treatment) 05/01/2010 - "Both of the 2 groups' final scores of the total 20 items and the most important 5 items of SNOT-20 and Lund-Kennedy and Lund-Mackay were greatly improved, however there is an obvious difference between them: the therapeutic effect of groups I is better than group II. SIT can reduce the recurrence of nasal polyps after operation, and improve the state after treatment." 04/01/2011 - "The score of CT scan was significantly decreased to 2.83 +/- 1.86 (t = 11.41, P < 0.01) in the CRS with nasal polyps group and to 2.43 +/- 1.91 (t = 12.86, P < 0.01) in the CRS without nasal polyps group after treatment. " 02/01/2010 - "The size of nasal polyps and the score of sinus shadows were assessed with nasal endoscopy and computed tomography (CT), respectively, before and after treatment. " 12/01/2008 - "Foxp3+ T regulatory cells (Tregs) are increased in nasal polyps (NP) after treatment with intranasal steroid." 09/01/2005 - "Olfactometry can help to estimate nasal polyps during and after treatment even in early stage."
3.	Heterologous Transplantation (Xenotransplantation) 05/01/2012 - "MUC7, which is primarily associated with the submucosa, as opposed to MUC4 and MUC5AC, which are primarily expressed in the epithelium, was significantly decreased in the nasal polyp xenografts. " 12/01/2009 - "Xenografts of human nasal polyp tissues were established after their subcutaneous implantation into NOD-scid IL2rgamma(null) mice. " 12/01/2009 - "Xenografts at 8 to 12 weeks after implantation were examined histologically and immunohistochemically to identify human inflammatory leukocytes and to determine whether the characteristic histopathologic characteristics of the nasal polyps were maintained for a prolonged period. " 12/01/2009 - "Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice." 01/01/2006 - "Human nasal polyp microenvironment maintained in viable and functional states as xenografts in SCID mice."
4.	Phototherapy (Light Therapy) 09/02/2010 - "The results suggest that phototherapy may represent a potential new treatment option in nasal polyps." 09/02/2010 - "Narrow-band UVB phototherapy of nasal polyps: results of a pilot study."
5.	Nebulizers and Vaporizers (Inhaler) 12/01/2001 - "Four weeks after surgery, nasal polyps recurred, but his condition was improved by oral administration of steroids and nebulizer treatment with steroids and fluconazole. "