Narcotic Antagonists (Opioid Antagonists)

09/15/2015 - "Peripherally acting mu-opioid antagonists are effective for opioid-induced constipation but are expensive. "
02/01/2011 - "Recently new effective opioid antagonists were introduced to act against constipation in patients on long-term opioid therapy. "
09/10/2009 - "Effectiveness of two opioid antagonists in treating opioid-induced constipation."
01/01/2009 - "Peripherally restricted opioid antagonists have been developed for the prevention and management of opioid induced constipation. "
11/01/2007 - "Peripherally acting opioid antagonists in the treatment of opiate-related constipation: a systematic review."

04/01/2013 - "Since the comprehensive review by Leavitt in 2009, few new studies on the use of opioid antagonists for pain have been published. "
04/01/2013 - "Published clinical trials, case reports and other sources were reviewed to determine the effectiveness and safety of opioid antagonists for use in relieving pain. "
01/01/1999 - "The aim of our study was to investigate the effect of intracerebroventricular (i.c.v.) administration of very low doses of opioid antagonists on the pain threshold, arterial blood pressure and body temperature of spontaneously hypertensive rats (SHR) with chronic pain. "
07/01/2014 - "The protocol focuses on avoiding bowel preparation and nasogastric tube, early feeding, nonnarcotic pain management and the use of cholinergic and μ-opioid antagonists. "
04/01/2013 - "Opioid antagonists for pain."

08/01/2011 - "Published reports on placebo-controlled clinical trials and other studies investigating the use of pure opioid antagonists for the prevention and treatment of opioid-induced pruritus (OIP) were evaluated. "
06/01/2013 - "Opioid antagonists and mixed agonist/antagonists appear to be the most useful for the management of opioid-induced pruritus. "
08/01/2011 - "Use of pure opioid antagonists for management of opioid-induced pruritus."
04/01/2003 - "Recently, evidence for a central mechanism for pruritus has been obtained and opioid antagonists have been tried clinically with some benefit, but their use is not widespread. "
11/01/1998 - "However, although opioid antagonists relieve itching to a large extent, the itching usually is not abolished completely. "

04/01/2010 - "Some treatments have proven efficacy in randomized clinical trials in patients with cholestatic disorders, such as anion exchange resins, rifampicin, opioid antagonists and ursodeoxycholic acid; the latter is especially useful in intrahepatic cholestasis of pregnancy."
06/01/2007 - "Depending on the underlying disease state resulting in cholestasis, phenobarbital, ursodiol, bile sequestering agents, and opioid antagonists appear to be most effective for treating pruritus related to intrahepatic cholestasis. "

10/01/1986 - "In addition, the patients who required opioid antagonists to reverse postoperative respiratory depression had lower clearance rates (1.5 +/- 0.7 vs 4.1 +/- 1.9 ml X kg-1 X min-1) and longer elimination half-life values (406 +/- 304 vs 87 +/- 53 min). "
01/01/1982 - "In this group however, fine patients developed a respiratory depression, often delayed in onset, associated with increased PaCO2 levels and/or bradypnea, requiring treatment with narcotic antagonists. "
01/01/1987 - "It is fortunate for anaesthetists who use opioids regularly, that recognition and treatment of respiratory problems are an integral part of their craft and that opioid antagonists are effective in reversing respiratory depression."
10/01/2011 - "Opioid antagonists such as naloxone to prevent or treat opioid-induced respiratory depression have a number of limitations. "
09/01/1988 - "The duration of respiratory depression induced by morphine 10 mg/70 kg was studied following the administration of one of two opioid antagonists. "