HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)

Subscribe to New Research on NADPH-Ferrihemoprotein Reductase

A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.

Also Known As:

Cytochrome P450 Reductase; Cytochrome P-450 Oxidase; Ferrihemoprotein P450 Reductase; NADPH Cytochrome P450 Oxidoreductase; NADPH Cytochrome P450 Reductase; NADPH-Cytochrome P450 Reductase; NADPH-P450 Reductase; Cytochrome P 450 Oxidase; Cytochrome P 450 Reductase; Ferrihemoprotein P 450 Reductase; NADPH Cytochrome P 450 Oxidoreductase; NADPH Cytochrome P 450 Reductase; NADPH Ferrihemoprotein Reductase; NADPH P450 Reductase; Oxidase, Cytochrome P-450; P-450 Oxidase, Cytochrome; P450 Reductase, Cytochrome; P450 Reductase, NADPH-Cytochrome; Reductase, Cytochrome P-450; Reductase, Cytochrome P450; Reductase, Ferrihemoprotein P-450; Reductase, Ferrihemoprotein P450; Reductase, NADPH-Cytochrome P450; Reductase, NADPH-Ferrihemoprotein; Reductase, NADPH-P450; Cytochrome P-450 Reductase; Ferrihemoprotein P-450 Reductase; NADPH Cytochrome P-450 Oxidoreductase; NADPH Cytochrome P-450 Reductase; NADPH Cytochrome c Reductase; NADPH:ferrihemoprotein oxidoreductase

Networked: 157 relevant articles (2 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Oxidoreductases: 9264
    - NADPH Oxidoreductases NADH
      - Cytochrome Reductases: 1
        NADPH-Ferrihemoprotein Reductase: 157
        NADPH-tetrazolium reductase: 4
        cotton CPRR1 protein
        cotton CPRR2 protein
        flavocytochrome P450 BM3 monoxygenases

Experts

1.	Patterson, Adam V: 6 articles (12/2013 - 09/2003)
2.	Ding, Xinxin: 5 articles (07/2015 - 03/2005)
3.	Wilson, William R: 4 articles (12/2013 - 06/2007)
4.	Zhang, Qing-Yu: 3 articles (07/2015 - 03/2005)
5.	Guise, Christopher P: 3 articles (12/2013 - 05/2013)
6.	Stratford, Ian J: 3 articles (12/2008 - 09/2003)
7.	Xie, Fang: 2 articles (07/2015 - 01/2014)
8.	Zhu, Yi: 2 articles (07/2015 - 01/2014)
9.	Su, Jiechuang: 2 articles (12/2013 - 05/2013)
10.	Smaill, Jeff B: 2 articles (12/2013 - 12/2013)

Related Diseases

1.	Neoplasms (Cancer) 08/15/2000 - "NADPH-cytochrome P450 reductase is predominant in metabolic activation of MC in hypoxic cancer cells. " 11/01/1997 - "P450-catalyzed drug metabolism is obligatorily dependent on electron input from the flavoenzyme NADPH-P450 reductase (RED), which is widely expressed in many cell types, including tumor cells. " 09/01/2000 - "These findings suggest that NADPH:cytochrome P450 reductase is an important enzyme in BRU59-21 metabolism in model systems of tumor hypoxia." 09/01/2000 - "Role of NADPH:cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia." 03/01/2006 - "Further enhancement of the efficacy of P450-based gene therapy can be achieved: by co-expression of P450 with the flavoenzyme NADPH-P450 reductase, which provides electrons required for P450 metabolic activity; by metronomic (anti-angiogenic) scheduling of the prodrug; by localized delivery of the prodrug to the tumor; and by combination with anti-apoptotic factors, which slow the death of the P450 'factory' cells and thereby enhance the bystander cytotoxic response. "
2.	Sarcoma (Soft Tissue Sarcoma) 12/01/1983 - "Extra-hepatic Walker sarcoma 256 produced a marked decrease (approximately 60%) in the levels of cytochrome P-450 and NADP-cytochrome P-450 reductase in rat liver endoplasmic reticulum, and a lesser decrease (approximately 20%) of cytochrome b5 and NADH-cytochrome b5 reductase. "
3.	Hepatocellular Carcinoma (Hepatoma) 04/01/1983 - "Characterization of NADPH-cytochrome P-450 reductase in a mouse hepatoma cell line." 12/20/1982 - "Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat hepatoma." 06/01/2011 - "Suppression of cytochrome P450 reductase (POR) expression in hepatoma cells replicates the hepatic lipidosis observed in hepatic POR-null mice." 12/22/1978 - "Cytochrome P-450 reductase has been at least partially purified from the Novikoff hepatoma and hepatoma 5123 t.c.(H). " 01/05/2006 - "HepG2 cells, a human hepatoma cell line, stably expressing NADPH-cytochrome P450 reductase (OR) and/or cytochrome P450 2D6 wild-type (CYP2D6-WT) or its variants (Pro34Ser, Gly42Arg, Arg296Cys and Ser486Thr) were established in the present study. "
4.	Anoxia (Hypoxia) 05/15/2013 - "In the present paper, we report a 6-nitroquinolone ester (FSL-61) as a fluorogenic probe for POR (NADPH:cytochrome P450 oxidoreductase) activity under hypoxia, and demonstrate its suitability of monitoring POR by flow cytometry. " 11/11/2009 - "Similar hypoxia-selective reduction of IQ-F occurred within A549 cells, which expresses NADPH:cytochrome P450 reductase. " 02/01/2000 - "Of these, three primary metabolites are 2-methylamino-7-aminomitosene, 1,2-cis and 1,2-trans-1-hydroxy-2-methylamino-7-aminomitosene, which are consistent with those previously observed in hypoxia using purified rat liver NADPH-cytochrome c reductase. " 09/01/2000 - "These findings suggest that NADPH:cytochrome P450 reductase is an important enzyme in BRU59-21 metabolism in model systems of tumor hypoxia." 09/01/2000 - "Role of NADPH:cytochrome P450 reductase in the hypoxic accumulation and metabolism of BRU59-21, a technetium-99m-nitroimidazole for imaging tumor hypoxia."
5.	Carcinoma (Carcinomatosis) 09/01/1997 - "II) We have examined the bioreductive enzyme activities of DTD and cytochrome P450 reductase and IC50's of MMC in 13 colon and gastric carcinoma cell lines. " 06/15/1996 - "To study the bioreductive enzymes responsible for MMC activation in tumor cells, we examined the enzyme activities of DT-diaphorase (DTD) and NADPH:cytochrome P-450 reductase in 13 colon and gastric carcinoma cell lines and then compared these activities to the respective cellular MMC sensitivity. " 05/01/1994 - "We studied the antitumor effects of KW-2149 in MMC-resistant variants of human colon carcinoma HT-29 (HT-29/MMC) and mouse hepatoma Hepa-I (C4, B13NBii1) cells, which are deficient in DT-diaphorase and cytochrome P450 reductase, respectively. " 12/01/1987 - "Administration of nicotinamide to Wistar rats (100 mg/kg body wt.) bearing Yoshida sarcoma (ascites) tumour as well as to Swiss and CBA mice (250 mg/kg body wt.) bearing the transplantable fibrosarcoma and the spontaneously induced mammary carcinoma, respectively, was shown to bring about a reversal of the decreased activity of NADPH-cytochrome c reductase in host livers of the tumour-bearing animals. " 02/01/2002 - "These results suggest that prostate areas susceptible to carcinoma induction have less protection by COMT, GSH, and quinone reductase and/or cytochrome P450 reductase, favoring reaction of CE-3,4-Q with DNA, presumably to initiate cancer."

Related Drugs and Biologics

1.	Cytochrome P-450 Enzyme System (Cytochrome P450)
2.	Cytochromes b5 (Cytochrome b5)
3.	NADP (NADPH)
4.	Cytochrome-B(5) Reductase (Methemoglobin Reductase)
5.	Carbon Monoxide
6.	Enzymes
7.	NADPH-Ferrihemoprotein Reductase (Cytochrome P450 Reductase)
8.	Oxidoreductases
9.	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)
10.	Aniline Hydroxylase

Related Therapies and Procedures

1.	Cardiopulmonary Resuscitation (CPR)
2.	Oral Administration
3.	Electrocoagulation (Electrocautery)