NAD+ Nucleosidase (NAD(P) Nucleosidase)

An enzyme that catalyzes the hydrolysis of nicotinamide adenine dinucleotide (NAD) to NICOTINAMIDE and ADENOSINE DIPHOSPHATE RIBOSE. Some are extracellular (ectoenzymes).The enzyme from some sources also catalyses the hydrolysis of nicotinamide adenine dinucleotide phosphate (NADP).

Also Known As:

NAD(P) Nucleosidase; Diphosphopyridine Nucleotidases; Ecto-NAD+ Glycohydrolase; NAD+ Nucleosidases; NAD-Glycohydrolase; NAD-Glycohydrolases; NADP Nucleosidase; NADP-Glycohydrolase; NADases; Ecto NAD+ Glycohydrolase; Glycohydrolase, Ecto-NAD+; Glycohydrolase, NAD+; NAD Glycohydrolase; NAD Glycohydrolases; NADP Glycohydrolase; Nucleosidase, NAD+; Nucleosidase, NADP; Nucleosidases, NAD+; Nucleotidase, Diphosphopyridine; Nucleotidases, Diphosphopyridine; DPNase; Diphosphopyridine Nucleotidase; NAD+ Glycohydrolase; NADase

Networked: 106 relevant articles (2 outcomes, 8 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Pentosyltransferases
        ADP Ribose Transferases: 198
        NAD+ Nucleosidase: 106
        ADP-ribosyl Cyclase: 38
  - Hydrolases: 2166
    - Glycoside Hydrolases: 871
      - N-Glycosyl Hydrolases: 36
        NAD+ Nucleosidase: 106
        ADP-ribosyl Cyclase: 38

Experts

1.	Wessels, Michael R: 7 articles (01/2022 - 10/2005)
2.	Caparon, Michael G: 5 articles (02/2016 - 07/2010)
3.	O'Seaghdha, Maghnus: 4 articles (12/2017 - 01/2013)
4.	Nurten, Rüstem: 4 articles (06/2014 - 02/2004)
5.	Chini, Claudia C S: 3 articles (01/2022 - 01/2016)
6.	Chini, Eduardo N: 3 articles (01/2022 - 01/2016)
7.	DiAntonio, Aaron: 3 articles (01/2022 - 01/2019)
8.	Milbrandt, Jeffrey: 3 articles (01/2022 - 01/2019)
9.	Velarde, Jorge J: 3 articles (01/2022 - 03/2016)
10.	Bastiat-Sempe, Benedicte: 3 articles (12/2017 - 09/2014)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "The Pharmacology of CD38/NADase: An Emerging Target in Cancer and Diseases of Aging." 06/01/2014 - "Serum levels of ADP-ribosylation and NAD glycohydrolase activity correlate well with tumor stage, stage of disease, serum CEA level, and site of lesion. " 06/01/2014 - "ADP-ribosylation and NAD glycohydrolase activity levels were correlated with tumor stage (p=0.05, p=0.001), stage of disease (p<0.001, p<0.001), serum CEA level (p<0.001, p<0.001), and site of lesion (p<0.001, p<0.001), respectively. " 07/01/2011 - "Erythrocyte and lymphocyte NAD(+) glycohydrolase levels were previously found to be elevated in cancer patients. " 11/15/1999 - "Increase of NAD glycohydrolase activity in uterine cervix cancers is caused by infiltration of lymphocytes."
2.	Inflammation (Inflammations) 05/30/2023 - "In particular, upregulation of the NADase CD38 by inflammation during aging contributes to mitochondrial dysregulation." 11/21/2022 - "EVs were able to attenuate the age-associated inflammation, inducing a decrease in the expression of TNF-α, iNOS, and the NADase CD38. " 01/01/2022 - "Here, we identified that deletion in mdx mice of CD38, a NAD+ glycohydrolase-producing modulators of Ca2+ signaling, led to a fully restored heart function and structure, with skeletal muscle performance improvements, associated with a reduction in inflammation and senescence markers. " 01/01/2022 - "At the functional level, the reduction of senescence-associated inflammation ensured sustained NAD+ levels in the plasma of AAV-LAV-BPIFB4 old mice by preventing the NADase CD38 increase in F4/80+ tissue-resident macrophages and Ly6Chigh pro-inflammatory monocytes of the spleen and bone marrow. " 01/01/2019 - "Conversely, the low expression of CD38/NADase was indicative of their inability to counteract NAD+-mediated OA inflammation. "
3.	Bites and Stings (Sting) 01/01/2023 - "However, the enzymatic activity of the NADase variants expressed by invasive strains suppresses STING-mediated type I IFN production. " 01/01/2023 - "Interplay between human STING genotype and bacterial NADase activity regulates inter-individual disease variability." 01/01/2022 - "The active bacterial TIR-STING structure reveals further cross-filament contacts that brace the assembly and coordinate packing of the associated TIR NADase effector domains at the base of the filament to drive NAD+ hydrolysis. " 01/01/2023 - "Here, we show that the outcome of invasive Streptococcus pyogenes infection is regulated by an interplay between human STING genotype and bacterial NADase activity. " 01/01/2023 - "Furthermore, the cardiac EC cGAS-STING pathway also regulates NAD homeostasis and mitochondrial bioenergetics in cardiomyocytes through the ecto-NADase activity of CD38. "
4.	Soft Tissue Infections 10/01/2005 - "We employed isogenic GAS mutants to assess the contribution of NADase activity to GAS virulence in vivo using mouse models of invasive soft-tissue infection and septicemia. " 01/01/2023 - "pyogenes soft tissue infection indicates that a STING genotype associated with reduced c-di-AMP-binding capacity combined with high bacterial NADase activity promotes a 'perfect storm' manifested in poor outcome, whereas proficient and uninhibited STING-mediated type I IFN production correlates with protection against host-detrimental inflammation. "
5.	Infections 01/01/2019 - "In this study, we use a macrophage infection model to investigate the NADase-dependent inhibition of IL-1β release. " 05/17/2010 - "The knockout mutant of the nga gene, which encodes NADase also showed reduced virulence in a mouse infection study. " 01/01/2023 - "These results reveal an immune-regulating function for bacterial NADase and provide insight regarding the host-pathogen genotype interplay underlying invasive infection and interindividual disease variability." 01/01/2023 - "Overall, this work delivers the structure-functional relationship of the NADase/SLO complex and pinpoints the key interacting residues that are central to the coordinated actions of NADase and SLO in the pathogenesis of GAS infection." 01/01/2023 - "Furthermore, the biological significance of the NADase/SLO complex in GAS virulence is demonstrated in a murine infection model. "

Related Drugs and Biologics

1.	NAD (NADH)
2.	cyclic diadenosine phosphate
3.	Enzymes
4.	Adenosine Diphosphate Ribose (ADP-Ribose)
5.	Niacinamide (Nicotinamide)
6.	Salts
7.	2'-nucleotidase
8.	NAD+ Nucleosidase (NAD(P) Nucleosidase)
9.	streptolysin O
10.	Virulence Factors (Pathogenicity Factors)

Related Therapies and Procedures

1.	Axotomy
2.	Drug Therapy (Chemotherapy)
3.	Braces