HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

N-Acetylmuramoyl-L-alanine Amidase (Autolysin)

Subscribe to New Research on N-Acetylmuramoyl-L-alanine Amidase

An autolytic enzyme bound to the surface of bacterial cell walls. It catalyzes the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell wall glycopeptides, particularly peptidoglycan. EC 3.5.1.28.

Also Known As:

Autolysin; LE-Enzyme; Murein Hydrolase; Peptidoglycan Hydrolase; T7 Endolysin; T7 Lysozyme; Amidase, N-Acetylmuramoyl-L-alanine; Amidohydrolase, Mucopeptide; Endolysin, T7; Hydrolase, Murein; Hydrolase, Peptidoglycan; LE Enzyme; Lysozyme, T7; N Acetylmuramoyl L alanine Amidase; Mucopeptide Amidohydrolase; Peptidoglycan amidohydrolase

Networked: 121 relevant articles (4 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes
- Enzymes: 34502
  - Hydrolases: 639
    - Amidohydrolases: 12
      - N-Acetylmuramoyl-L-alanine Amidase: 121
        Bacillus licheniformis CwlL protein
        Bacillus subtilis cwlC protein
        Bacillus subtilis CwlD protein
        Bacillus subtilis CwlH protein
        Bacillus subtilis LytE protein
        Bacteria AmpD protein
        EJL amidase
        gamma phage PlyG lysin
        L-11 cell wall lytic enzyme
        Listeria monocytogenes Auto autolysin
        Staphylococcus aureus LytH protein
        Staphylococcus phage Twort PLYTW protein
        Streptococcus LytB protein
        Streptococcus LytC protein

Experts

1.	Chapot-Chartier, Marie-Pierre: 5 articles (02/2013 - 01/2009)
2.	Courtin, Pascal: 5 articles (02/2013 - 01/2009)
3.	Pons, Jean-Louis: 3 articles (03/2014 - 01/2009)
4.	Henriques-Normark, Birgitta: 3 articles (02/2014 - 03/2012)
5.	Normark, Staffan: 3 articles (01/2014 - 01/2004)
6.	Götz, Friedrich: 3 articles (01/2012 - 01/2009)
7.	García, Pedro: 2 articles (10/2015 - 09/2007)
8.	Peters, Georg: 2 articles (01/2015 - 12/2010)
9.	Heilmann, Christine: 2 articles (01/2015 - 12/2010)
10.	Pestel-Caron, Martine: 2 articles (03/2014 - 01/2009)

Related Diseases

1.	Infection 01/01/2010 - "However, presence of lytA gene in all the isolates signifies that irrespective of site of isolation, kind of infection caused, autolysin is an obligate necessity for this organism." 01/01/2008 - "[Identification and characterization of a novel infection-related factor (cell wall hydrolase/autolysin) of Streptococcus suis serotype 2]." 03/01/2007 - "Identification of IspC, an 86-kilodalton protein target of humoral immune response to infection with Listeria monocytogenes serotype 4b, as a novel surface autolysin." 12/01/2006 - "A peptidoglycan hydrolase motif within the mycobacteriophage TM4 tape measure protein promotes efficient infection of stationary phase cells." 08/01/2005 - "T7 lysozyme helps lyse the host cell by degrading its cell wall at the end of infection, allowing viral escape to infect new hosts. "
2.	Autolysis 04/01/2000 - "Previous studies in our laboratory have shown that the Staphylococcus aureus LytSR two-component regulatory system affects murein hydrolase activity and autolysis. " 07/01/2015 - "Newman ΔtagO showed enhanced susceptibility to autolysis, and an autolysin (atl) tagO double mutant abrogated this phenotype. " 04/01/2015 - "Consistent with reduced autolysis, the transcription levels of the autolysin genes, lytM and atlE, were reduced in the absence of Pfs. " 02/01/2015 - "The control of protease production mediates the processing of the major autolysin, Atl, and thus regulates the rate of autolysis. " 01/01/2015 - "To unravel the role of autolysis, an autolysin-coding gene, CA_C0554, was disrupted by using ClosTron system to obtain the mutant C. "
3.	Peritonitis 11/01/1998 - "The virulence of TX5127 was similar to that of OG1RF in the mouse peritonitis model, indicating that the autolysin of E. " 09/01/2007 - "Pneumococcal LytA autolysin, a potent therapeutic agent in experimental peritonitis-sepsis caused by highly beta-lactam-resistant Streptococcus pneumoniae."
4.	Sepsis (Septicemia) 09/01/2007 - "Pneumococcal LytA autolysin, a potent therapeutic agent in experimental peritonitis-sepsis caused by highly beta-lactam-resistant Streptococcus pneumoniae."
5.	Communicable Diseases (Infectious Diseases) 10/01/2005 - "In addition to phage particles per se, purified phage-encoded peptidoglycan hydrolase (lysin) is also reported to be effective for the treatment of bacterial infectious diseases caused by gram-positive bacteria such as Streptococcus pyogenes, S. "

Related Drugs and Biologics

1.	Streptococcus pneumoniae plY protein
2.	lysin
3.	Chloramphenicol (Chloromycetin)
4.	Amino Acids
5.	Tetracycline (Achromycin)
6.	Staphylococcal Protein A (A, Protein)
7.	Proteins (Proteins, Gene)
8.	Oxacillin (Prostaphlin)
9.	Lipase (Acid Lipase)
10.	Heme (Haem)

Related Therapies and Procedures

1.	Catheters
2.	Intramuscular Injections
3.	Aftercare (After-Treatment)