Myoglobin

12/01/1979 - "Both myoglobin and CPK were equally effective in providing an index of the extent of histopathologic myocardial infarction. "
07/22/2008 - "In vivo administration of nitrite reduced myocardial infarction by 61% in myoglobin(+/+) mice, whereas in myoglobin(-/-) mice nitrite had no protective effects. "
04/01/1994 - "Combining the electrocardiogram and myoglobin data substantially improved the sensitivity and predictive accuracy for the diagnosis of acute myocardial infarction."
10/01/1982 - "Diagnostic specificity of serum myoglobin radioimmunoassay for acute myocardial infarction is improved by using age-, sex-, and race-specific reference ranges."
11/01/2002 - "The 37 patients in the study were a high-risk population with over 50% presenting with a Thrombolysis in Myocardial Infarction (TIMI) risk score of greater or equal to 3. Myoglobin was the most sensitive marker (100% sensitivity) in early prediction of patients who were subsequently diagnosed to have a myocardial infarction. "

10/01/1995 - "This potential for 100% predictability in excluding AMI by the use of serial myoglobin determinations will be very helpful in the correct triage of patients presenting with acute chest pain."
07/01/2010 - "The automated H-FABP (by LTIA) is superior to cTnT, CK-MB, myoglobin, and H-FABP (by ELISA) tests for the diagnosis of AMI in patients admitted within 4 hours from the onset of chest pain."
07/24/2005 - "Our preliminary clinical data suggests that FABP had a better diagnostic performance (sensibility = 100%) than myoglobin (sensibility = 75%) to detect AMI in the first hours after the onset of the chest pain and myoglobin/CAIII ratio (specificity = 92.9%) improved the myoglobin specificity. "
06/01/2004 - "Reevaluation of myoglobin for acute chest pain evaluation: would false-positive results on "first-draw" specimens lead to increased hospital admissions?"
06/01/1996 - "A prospective, observational test performance study for the recognition of AMI was done using serial myoglobin assays of 42 admitted chest pain patients at a large, urban teaching hospital ED. "

04/01/2005 - "SHF hemofiltration achieved a much greater clearance of myoglobin than conventional hemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renal failure."
09/01/1997 - "The effectiveness on each method of blood purification was evaluated in this study based on the clearance of myoglobin and the length of time until recovery from acute renal failure (ARF). "
07/01/1988 - "In order to prevent myonephropathic metabolic syndrome (MNMS) following acute arterial occlusion of the extremities, the efficacy of plasma filtration to eliminate myoglobin which causes acute renal failure and other metabolites was evaluated by experimental model. "
02/01/1990 - "This study of the clinical course of nine patients with myoglobinuric acute renal failure reveals continuous arterio-venous hemofiltration (CAVH) to have an effective clearance for myoglobin. "
08/01/2013 - "Use of myoglobin as a marker and predictor in myoglobinuric acute kidney injury."

01/01/2014 - "We aimed to: i) assess the efficacy of CRRT in removing myoglobin; ii) investigate the influence of CRRT on mortality and kidney-related outcomes; and iii) evaluate the safety of CRRT for the treatment of people with rhabdomyolysis. "
06/01/2012 - "The present study investigates myoglobin-induced apoptosis in HK-2 cells (human renal proximal tubule cells) to discover some of the mechanisms involved in rhabdomyolysis related AKI. "
01/01/2011 - "No cases of rhabdomyolysis (the breakdown of muscle fibres resulting in the release of muscle fibre contents (myoglobin) into the bloodstream) occurred in 274 patients enrolled in three studies. "
05/01/2014 - "An extended two compartment model is proposed to describe the dynamics of myoglobin in rhabdomyolysis patients undergoing dialysis. "
05/01/2014 - "Kinetic modelling of haemodialysis removal of myoglobin in rhabdomyolysis patients."

01/10/2014 - "Numerous studies have implicated that hypoxia regulates myoglobin expression to allow adaptation to conditions of hypoxic stress. "
03/01/2009 - "In vitro and in vivo studies revealed that hypoxia in the presence or absence of exercise-induced stimuli reprograms calcium signaling and modulates myoglobin gene expression. "
03/01/2009 - "Numerous studies have implicated hypoxia in the regulation of myoglobin expression as an adaptive response to hypoxic stress. "
12/01/2002 - "The present study explores the role of myoglobin (Mb) in retarding the development of anoxia in the perfused working rat heart. "
03/01/2015 - "Additionally, we found a correlation between the prosurvival effect of hypoxia/NaNO2 pretreatment and the myoglobin content of the cells by comparing neonatal rat ventricular and atrial CMs, which express high and low myoglobin respectively. "