Myofascial Pain Syndromes (Myofascial Pain Syndrome)

Muscular pain in numerous body regions that can be reproduced by pressure on TRIGGER POINTS, localized hardenings in skeletal muscle tissue. Pain is referred to a location distant from the trigger points. A prime example is the TEMPOROMANDIBULAR JOINT DYSFUNCTION SYNDROME.

Also Known As:

Networked: 371 relevant articles (62 outcomes, 119 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Pain (Aches)
2.	Low Back Pain (Lumbago)
3.	Fibromyalgia (Fibrositis)
4.	Neck Pain (Cervicalgia)
5.	Pelvic Pain

Experts

1.	Fregni, Felipe: 9 articles (01/2020 - 10/2013)
2.	Caumo, Wolnei: 8 articles (01/2018 - 10/2013)
3.	Torres, Iraci L S: 7 articles (01/2018 - 10/2013)
4.	Grosman-Rimon, Liza: 6 articles (12/2022 - 09/2016)
5.	Kumbhare, Dinesh: 6 articles (12/2022 - 09/2016)
6.	Brietzke, Aline: 5 articles (01/2018 - 10/2013)
7.	Deitos, Alicia: 5 articles (01/2018 - 10/2013)
8.	Lee, Shi-Uk: 4 articles (08/2021 - 03/2013)
9.	Dolatkhah, Neda: 4 articles (01/2021 - 01/2020)
10.	Gao, Qian: 4 articles (01/2020 - 01/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Myofascial Pain Syndromes:

1.	Lidocaine (Xylocaine)FDA LinkGeneric 01/01/2019 - "This study indicated that kinesiotaping may be useful to increase the efficacy of myofascial trigger point lidocaine injection in myofascial pain syndrome." 01/01/2019 - "Does kinesiotaping increase the efficacy of lidocaine injection in myofascial pain syndrome treatment? " 10/01/2012 - "The aim of this study was to compare topical 5% lidocaine patch with placebo patch in the treatment of myofascial pain syndrome of the upper trapezius. " 01/01/2009 - "This study aimed to assess the effectiveness of lidocaine iontophoresis for inactivation of trigger points (TrPs) in the treatment of myofascial pain syndrome (MPS). " 03/01/2013 - "[Comparative study on effect of acupuncture and lidocaine block for lumbar myofascial pain syndrome]."
2.	Local AnestheticsIBA 02/01/2017 - "Comparison between ultrasound-guided interfascial pulsed radiofrequency and ultrasound-guided interfascial block with local anesthetic in myofascial pain syndrome of trapezius muscle." 06/01/2007 - "Comparison between newer local anesthetics for myofascial pain syndrome management." 07/01/2001 - "Water-diluted local anesthetic for trigger-point injection in chronic myofascial pain syndrome: evaluation of types of local anesthetic and concentrations in water." 11/01/2020 - "However, there is limited data on the relationship between myofascial pain syndromes (MFPS) and MS. The aim of the study to investigate the frequency and impact of MFPS in patients with MS, to evaluate the effect of local anesthetic injections for short-term treatment. " 01/01/2020 - "Ashi Acupuncture Versus Local Anesthetic Trigger Point Injections in the Treatment of Abdominal Myofascial Pain Syndrome: A Randomized Clinical Trial."
3.	Type A Botulinum Toxins (Botox)FDA Link 12/01/2016 - "The authors conducted a systematic review to study the efficacy of botulinum toxin type A (BoTN-A) in the treatment of myofascial pain syndrome. " 01/01/2006 - "Our study shows that there was no difference between the effect of small doses of botulinum toxin A and those of physiological saline in the treatment of myofascial pain syndrome." 01/01/2006 - "The effect of small doses of botulinum toxin a on neck-shoulder myofascial pain syndrome: a double-blind, randomized, and controlled crossover trial." 12/01/2016 - "Botulinum toxin type A for the treatment of head and neck chronic myofascial pain syndrome: A systematic review and meta-analysis." 07/25/2014 - "To assess the effectiveness and safety of botulinum toxin A (BTXA) in the treatment of myofascial pain syndrome (MPS), excluding MPS in neck and head muscles. "
4.	salicylhydroxamic acid (SHAM)IBA 03/01/2018 - "Comparision of the effectiveness of ESWT and ultrasound treatments in myofascial pain syndrome: randomized, sham-controlled study." 01/01/2022 - "Fifty male volunteers (age 25.00 ± 1.05 years) with trapezius myofascial pain syndrome were randomly allocated into intervention group (E-WAA treatment) or sham control group at a 1:1 ratio. " 03/01/2013 - "The objective of this study was to test the hypothesis that dry needling is more effective than sham dry needling in the treatment of myofascial pain syndrome (MPS). " 01/01/2021 - "The randomized controlled trials comparing extracorporeal shock wave therapy with sham extracorporeal shock wave therapy or other treatments for patients with myofascial pain syndrome in the neck and shoulder patients were included. " 03/01/2018 - "[Purpose] The purpose of this study is to compare effectiveness of extracorporeal shock wave therapy (ESWT), ultrasound (US) and sham ESWT in the treatment of myofascial pain syndrome (MPS). "
5.	Botulinum Toxins (Botulinum Toxin)IBA 01/01/2018 - "Previous studies evaluating the efficacy of botulinum toxin for the treatment of myofascial pain syndrome are limited, with variable results. " 01/01/2013 - "Although the use of botulinum toxin to treat myofascial pain syndrome (MPS) has been investigated in many clinical trials, the results are contradictory. " 10/01/2012 - "Problems that were common to the studies were robust placebo responders, incomplete treatment of a regional myofascial pain syndrome, inappropriate or confounding control populations or treatments, and inappropriate time periods for assessment of outcomes, or misinterpretation of the time-frame of action of botulinum toxin. " 01/01/2023 - "However, there is no botulinum neurotoxin injection guideline, and the most appropriate injection site based on topographical anatomic information for this injection to effectively treat myofascial pain syndrome in the infraspinatus muscle is unclear. " 01/01/2023 - "Botulinum neurotoxin injection is a valuable treatment method for patients with myofascial pain syndrome in the infraspinatus muscle. "
6.	Analgesics (Analgesic Drugs)IBA 01/01/2022 - "There were two goals to this study: the first goal was to research the analgesic effectiveness of erector spinae plane block (ESPB) added to the treatment after trapezius muscle injection (TMI) and the second was to investigate whether repeated TMI increases the analgesic effect in myofascial pain syndrome (MPS). " 02/01/2011 - "On the other hand, there is convincing evidence that BoNTA lacks strong analgesic effects in patients with myofascial pain syndrome. " 10/01/2002 - "The use of topical analgesics for myofascial pain syndrome is the focus of this review. " 04/01/2019 - "Assessment of predisposing factors in myofascial pain syndrome and the analgesic effect of trigger point injections - A primary therapeutic interventional clinical trial." 01/01/2023 - "We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan (GV3) in patients with lumbar disc herniation (LDH) and myofascial pain syndrome (MPS). "
7.	Oxygen (Dioxygen)IBA 01/01/2023 - "This study measured cerebral blood oxygen changes in patients with myofascial pain syndrome (MPS) using functional near-infrared spectroscopy (fNIRS). " 01/01/2009 - "The aim of the present study was to evaluate the effects of hyperbaric oxygen (HBO) therapy on myofascial pain syndrome (MPS). " 09/01/2023 - "This study aims to compare effectiveness of oxygen-ozone injection versus lidocaine injection on the trigger point in the treatment of myofascial pain syndrome (MPS). " 09/01/2023 - "Comparison of the efficacy of oxygen-ozone and lidocaine injections in the treatment of myofascial pain syndrome: A randomized clinical trial."
8.	incobotulinumtoxinAFDA Link 11/01/2021 - "The aim was to evaluate the effectiveness and safety of IncobotulinumtoxinA (IncoA) for the management of myofascial pain syndrome (MPS) in refractory patients. " 11/01/2021 - "Retrospective study of the clinical effect of incobotulinumtoxinA for the management of myofascial pain syndrome in refractory patients." 11/01/2006 - "Botulinum type A toxin (BoNT-A) has antinociceptive and muscle-relaxant properties and may help relieve the symptoms of myofascial pain syndrome. " 11/01/2011 - "Fixed-location treatment with BoNT-A of patients with upper back myofascial pain syndrome did not lead to a significant improvement of the main target parameter in week 5 after treatment. " 11/01/2011 - "Patients with moderate-to-severe myofascial pain syndrome affecting cervical and/or shoulder muscles (10 trigger points, disease duration 6-24 months) and moderate-to-severe pain intensity were randomized to BoNT-A (N = 81) or saline (N = 72). "
9.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/01/2022 - "There is strong evidence that up to 85% of patients with CPP have serious dysfunctions of the musculoskeletal system, including abdominal myofascial pain syndrome (AMPS). " 11/01/2009 - "Abdominal myofascial pain syndrome is a highly prevalent disease associated with CPP, and because of this physicians should get used to make a precise and early diagnosis in order to avoid additional and unnecessary investigation." 03/01/2015 - "Myofascial pain syndrome of the pelvic floor (MPSPF) is a common disease in the context of chronic pelvic pain (CPP); however, there is currently no gold-standard test to diagnose it. " 03/01/2008 - "The purpose of this study was then to investigate the prevalence of major depression in chronic pain patients (CPP) with myofascial pain syndrome (MPS) and to investigate the relationship between some clinical parameters and level of depression, utilizing a healthy control group without MPS. " 12/01/2017 - "Objective: Strong evidence shows that 85% of women with chronic pelvic pain (CPP) have musculoskeletal disorders, such as abdominal myofascial pain syndrome (AMPS). "
10.	Adrenal Cortex Hormones (Corticosteroids)IBA 07/01/2009 - "BTX is being used increasingly for myofascial pain syndromes, and some studies have demonstrated superior efficacy to corticosteroid injection. " 10/19/2020 - "Corticosteroid TPI was more effective compared to ESWT in short-term controlling of pain and disability caused by myofascial pain syndrome of QL muscle. " 12/01/2007 - "Myofascial pain syndrome (MPS) may persist for many years and is often refractory to traditional therapeutic approaches including pharmacotherapy, focal tenderness infiltration by local anesthetic and corticosteroids, physical therapy and behavioral modification. "

Therapies and Procedures

1.	Dry Needling 01/01/2023 - "Evidence has shown that dry needling (DN) is effective for myofascial pain syndrome (MPS). " 07/01/2021 - "Dry needling has been found to be effective in various myofascial pain syndromes and musculoskeletal conditions. " 01/01/2022 - "To compare the efficacy of platelet-rich plasma (PRP) injection vs dry needling (DN) for management of trigger points in the masseter muscle in myofascial pain syndrome (MPS) patients. " 01/01/2022 - "Comparative Efficacy of Platelet-Rich Plasma and Dry Needling for Management of Trigger Points in Masseter Muscle in Myofascial Pain Syndrome Patients: A Randomized Controlled Trial." 01/01/2017 - "To compare the efficacy of two different dry needling (DN) techniques (deep dry needling & peppering) in myofascial pain syndrome (MPS). "
2.	Therapeutics 12/01/2018 - "Our findings show that conventional US therapy is effective in the treatment of myofascial pain syndrome." 07/01/2023 - "Comparison of kinesio taping, trigger point injection, and neural therapy in the treatment of acute myofascial pain syndrome: A randomized controlled study." 12/01/2018 - "This study aims to evaluate the effectiveness of conventional ultrasound (US) therapy in the treatment of myofascial pain syndrome. " 11/24/2023 - "Bowen therapy and tennis ball technique are also recommended for treating myofascial pain syndrome. " 06/01/2023 - "To investigate the effectiveness of Bowen therapy in managing myofascial pain syndrome with symptoms lasting for more than six weeks. "
3.	Extracorporeal Shockwave Therapy 07/01/2018 - "To compare the efficacy of high- and low-energy extracorporeal shock wave therapy (ESWT) for patients with myofascial pain syndrome (MPS) of the upper trapezius. " 01/01/2021 - "The aim of the study was to investigate the efficacy of extracorporeal shock wave therapy on myofascial pain syndrome in the neck and shoulder compared with that of other treatments. " 01/01/2021 - "To compare the efficacy of extracorporeal shock wave therapy versus standard care (ultrasound + hot pack + self-stretch-exercises) in treatment of neck and upper back myofascial pain syndrome. " 01/01/2021 - "Although studies examined kinesiological taping (KT) and extracorporeal shock wave therapy (ESWT) in myofascial pain syndrome (MPS), no study has yet compared these two treatments. " 07/18/2023 - "Instrumented assisted soft tissue mobilization vs extracorporeal shock wave therapy in treatment of myofascial pain syndrome."
4.	Injections 06/01/1995 - "Our study shows that injections of sterile water are substantially more painful but demonstrate no better clinical outcome than similar injections of saline as a method to treat patients with chronic myofascial pain syndrome." 09/01/1994 - "The purpose of this study was to investigate factors that may influence the outcome of trigger point injections for myofascial pain syndrome. " 01/01/2021 - "A 37-year-old male patient presented with myofascial pain syndrome and was given trigger point injections in trapezius muscles under ultrasound guidance. " 12/04/2020 - "Sonography-guided trigger point injections in abdominal myofascial pain syndrome." 07/01/2020 - "PRGF injections in masseter muscle affected by myofascial pain syndrome are an effective treatment method. "
5.	Ultrasonic Therapy 07/01/2015 - "Efficacy of Pulsed and Continuous Therapeutic Ultrasound in Myofascial Pain Syndrome: A Randomized Controlled Study." 01/01/2015 - "Efficacy of conventional ultrasound therapy on myofascial pain syndrome: a placebo controlled study." 12/01/2018 - "Effectiveness of Ultrasound Therapy on Myofascial Pain Syndrome of the Upper Trapezius: Randomized, Single-Blind, Placebo-Controlled Study." 01/01/2017 - "Effectiveness of ultrasound therapy for myofascial pain syndrome: a systematic review and meta-analysis." 07/01/2014 - "A comparison of the effectiveness of low-, moderate- and high-dose ultrasound therapy applied in the treatment of myofascial pain syndrome."