Myocardial Depressant Factor

A low molecular weight peptide of about 800-1000 having a negative inotropic effect. It is released into the circulation during experimental hemorrhagic pancreatitis, severe ischemia, and postoligemic shock.

Also Known As:

Networked: 95 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Pathan, Nazima: 3 articles (07/2011 - 10/2002)
2.	Levin, Michael: 3 articles (07/2011 - 10/2002)
3.	Harding, Sian E: 3 articles (07/2011 - 10/2002)
4.	Hemingway, Cheryl A: 2 articles (07/2011 - 01/2004)
5.	Relman, David A: 2 articles (07/2011 - 01/2004)
6.	Waddell, Simon J: 1 article (07/2011)
7.	Eleftherohorinou, Hariklia: 1 article (07/2011)
8.	Franklin, Joanne L: 1 article (07/2011)
9.	Wright, Victoria J: 1 article (07/2011)
10.	Dennis, Jayne L: 1 article (07/2011)

Related Diseases

1.	Shock 12/01/1991 - "Lipid-soluble cardiodepressant factor vs. water-soluble myocardial depressant factor-like substances in shock." 04/01/1989 - "Moreover PAF receptor antagonists attenuate the release of secondary toxic factors in shock, such as myocardial depressant factor. " 02/01/1988 - "These data suggest that theta-toxin-induced shock could be mediated by an endogenous myocardial depressant factor." 01/01/1983 - "Pharmacologic and surgical modulation of myocardial depressant factor formation and action during shock." 07/15/1982 - "The pathophysiologic role of myocardial depressant factor as a mediator of circulatory shock."
2.	Hemorrhagic Shock 06/01/1974 - "Pancreatic hypoperfusion and the production of a myocardial depressant factor in hemorrhagic shock." 03/01/1969 - "Further characterization of a myocardial depressant factor present in hemorrhagic shock." 08/01/1967 - "Characterization of a myocardial depressant factor present in hemorrhagic shock." 06/01/1970 - "Influence of hemodialysis on a myocardial depressant factor in hemorrhagic shock." 03/01/2005 - "Although this myocardial disorder is associated with increased expression of tumor necrosis factor-alpha (TNF-alpha), the role of TNF-alpha as a myocardial depressant factor in hemorrhagic shock remains to be determined. "
3.	Wounds and Injuries (Trauma) 05/01/1987 - "Pentobarbital anesthetized rats (35 kg/mg) subjected to Noble-Collip drum trauma were characterized by a 128 +/- 16 min survival time and a 4-fold increase in plasma myocardial depressant factor (MDF) activity. " 01/01/1988 - "Traumatic shock was produced by Noble Collip drum trauma and was characterized by marked hypotension, a 4- to 5-fold increase in plasma cathepsin D and myocardial depressant factor activities, and survival time of 95 +/- 15 minutes. " 01/01/1985 - "Anesthetized rats subjected to Noble-Collip drum trauma developed a shock state characterized by a survival time of 1.7 +/- 0.3 h, a sixfold increase in plasma cathepsin D activity, and a fourfold increase in plasma myocardial depressant factor (MDF) activity. " 05/01/1990 - "Treatment with BN 50739 (10 mg/kg, i.v.) 10 min post-trauma prolonged survival time to 3.14 +/- 0.44 h (p less than 0.01) and attenuated the accumulations of cathepsin D (5.8 vs. 12.5 U/ml, p less than 0.01), free amino-nitrogen (4.6 vs. 12.5 U/ml, p less than 0.001) and myocardial depressant factor (19.4 vs. 65.1 U/ml, p less than 0.001). " 07/01/1988 - "Pentobarbital (35 mg/kg) anesthetized rats subjected to Noble-Collip drum trauma were characterized by a 82 +/- 12 min survival time, a 20-fold increase in plasma cathepsin D activity, and a 6-fold increase in plasma myocardial depressant factor (MDF) activity. "
4.	Traumatic Shock 07/01/1988 - "Therefore, L-655,2340 does not stabilize lysosomal membranes directly, but exerts an anti-proteolytic action which appears to curtail the production of a myocardial depressant factor by the ischemic pancreas, thus protecting during traumatic shock. " 10/01/1984 - "The traumatic shock model was characterized by a 4.5-fold increase in plasma cathepsin D activity, a 4-fold increase in plasma myocardial depressant factor (MDF) activity, and a mean survival time of 1.5 +/- 0.2 h. " 01/01/1988 - "Traumatic shock was produced by Noble Collip drum trauma and was characterized by marked hypotension, a 4- to 5-fold increase in plasma cathepsin D and myocardial depressant factor activities, and survival time of 95 +/- 15 minutes. " 01/01/1981 - "MK-447, a free radical scavenger, at 1-4 mg/kg, was found to prolong survival in traumatic shock and to prevent the plasma appearance of a myocardial depressant factor (MDF) in shock rats. " 07/15/1982 - "Myocardial Depressant Factor (MDF) is a small peptide circulating in the blood of all mammalian species tested in a variety of shock states including endotoxic, hemorrhagic, cardiogenic, bowel ischemic, acute pancreatitis, burn, and traumatic shock. "
5.	Cardiogenic Shock 03/01/1978 - "Biochemical determinations failed to identify a single specific "myocardial depressant factor" in the plasma of patients and dogs with cardiogenic shock. " 10/01/1974 - "[Serial changes in myocardial depressant factor (Lefer) activities in cardiogenic shock]." 06/24/1974 - "Letter: Myocardial depressant factor in cardiogenic shock." 08/01/1973 - "[Characterization of a myocardial depressant factor isolated from dogs with cardiogenic shock]." 07/01/1971 - "Production of a myocardial depressant factor in cardiogenic shock."

Related Drugs and Biologics

1.	Glucocorticoids
2.	Catecholamines
3.	Angiotensins
4.	milk-derived factor
5.	Cathepsin D
6.	Pentobarbital (Nembutal)
7.	Peptides
8.	Nitrogen
9.	salicylhydroxamic acid (SHAM)
10.	Thromboxane Receptors (Thromboxane Receptor)

Related Therapies and Procedures

1.	Catheters
2.	Kidney Transplantation
3.	Renal Dialysis (Hemodialysis)