Myelin Proteins

Proteins found in the myelin sheath. The major proteins of central nervous system myelin include: MYELIN PROTEOLIPID PROTEIN; MYELIN BASIC PROTEINS; and MYELIN-ASSOCIATED GLYCOPROTEIN. The major proteins of peripheral nervous system myelin include: MYELIN BASIC PROTEINS (myelin P1 protein and MYELIN P2 PROTEIN); MYELIN P0 PROTEIN; and MYELIN-ASSOCIATED GLYCOPROTEIN.

Also Known As:

Networked: 269 relevant articles (3 outcomes, 19 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Love, Seth: 3 articles (01/2015 - 07/2013)
2.	Miller, Stephen D: 3 articles (02/2010 - 02/2002)
3.	Karpus, William J: 3 articles (02/2010 - 07/2004)
4.	Kipnis, Jonathan: 3 articles (06/2005 - 10/2002)
5.	Schwartz, Michal: 3 articles (06/2005 - 10/2002)
6.	Wellington, Dannielle: 2 articles (05/2014 - 07/2013)
7.	Esiri, Margaret M: 2 articles (05/2014 - 07/2013)
8.	Barker, Rachel: 2 articles (05/2014 - 07/2013)
9.	Skaper, Stephen D: 2 articles (01/2012 - 08/2005)
10.	Sedzik, Jan: 2 articles (06/2011 - 01/2008)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 05/19/2010 - "Spinal cord injury studies revealed an identical in vivo hierarchy of these three myelin proteins. " 04/01/2002 - "Lymphocytes respond to myelin proteins after spinal cord injury (SCI) and may contribute to post-traumatic secondary degeneration. " 11/26/2002 - "Here we show that this ability, assessed by retinal ganglion cell survival after optic nerve injury or locomotor activity after spinal cord contusion, is decreased if the animals were immunized as neonates with myelin proteins (resulting in their nonresponsiveness as adults to myelin proteins) or injected with naturally occurring regulatory CD4(+)CD25(+) T cells immediately after the injury, and is improved by elimination of these regulatory T cells. " 06/01/2009 - "Effects of progesterone on oligodendrocyte progenitors, oligodendrocyte transcription factors, and myelin proteins following spinal cord injury." 05/01/2003 - "Spinal cord injury (SCI) evokes an increase in intracellular free Ca(2+) level resulting in activation of calpain, a Ca(2+)-dependent cysteine protease, which cleaves many cytoskeletal and myelin proteins. "
2.	Diabetic Neuropathies (Diabetic Neuropathy) 11/01/1987 - "The results suggest that abnormal protein phosphorylation, particularly of myelin proteins, is a feature of experimental diabetic neuropathy and that the changes are most pronounced in the distal portion of the nerve." 06/01/2007 - "Considering the functional significance of myelin proteins, this impairment of protein expression is possibly involved in the pathogenesis of diabetic neuropathy, including that in brain disorders." 02/23/2007 - "In the model of STZ-induced of diabetic neuropathy, chronic treatment for 1 month with P, or with its derivatives, DHP and THP, counteracted the impairment of nerve conduction velocity (NCV) and thermal threshold, restored skin innervation density, and improved Na(+),K(+)-ATPase activity and mRNA levels of myelin proteins, such as glycoprotein zero and peripheral myelin protein 22, suggesting that these neuroactive steroids, might be useful protective agents in diabetic neuropathy. "
3.	Optic Nerve Injuries 11/26/2002 - "Here we show that this ability, assessed by retinal ganglion cell survival after optic nerve injury or locomotor activity after spinal cord contusion, is decreased if the animals were immunized as neonates with myelin proteins (resulting in their nonresponsiveness as adults to myelin proteins) or injected with naturally occurring regulatory CD4(+)CD25(+) T cells immediately after the injury, and is improved by elimination of these regulatory T cells. "
4.	Human Influenza (Influenza) 04/10/2001 - "These data support the clinical observations that influenza vaccination is effective and safe in patients with MS with respect to cellular immunoreactivity against two main CNS myelin proteins."
5.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 07/01/1984 - "Chronic experimental allergic encephalomyelitis in guinea pigs: immunologic studies on the two major myelin proteins." 03/15/2005 - "Murine experimental autoimmune encephalomyelitis (EAE) is a CD4+ T cell-mediated autoimmune disorder directed against myelin proteins within the CNS. " 08/15/2001 - "Gender differences in cytokine production have been observed in splenocytes of experimental autoimmune encephalomyelitis mice stimulated with myelin proteins and may underlie gender differences in susceptibility. " 12/01/1997 - "Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the central nervous system (CNS) in which clinical neurological signs and histopathologic changes of disease can be suppressed by feeding CNS myelin proteins. " 09/15/1996 - "Experimental autoimmune encephalomyelitis is a disease of the central nervous system that can be readily induced in a variety of species by immunization with myelin proteins. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Glycoproteins (Glycoprotein)
3.	Adenosine Triphosphatases (ATPase)
4.	Protective Agents
5.	Steroids
6.	Proteins (Proteins, Gene)
7.	Peptides
8.	Calpain
9.	Transcription Factors (Transcription Factor)
10.	Immunoglobulin M (IgM)

Related Therapies and Procedures

1.	Transplantation (Transplant Recipients)
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration