Mycophenolic Acid (Cellcept)

Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.

Also Known As:

Cellcept; Mycophenolate Mofetil; Mycophenolate Mofetil Hydrochloride; Mycophenolate Sodium; Mycophenolic Acid Morpholinoethyl Ester; Myfortic; RS 61443; RS-61443; Sodium Mycophenolate; Mofetil Hydrochloride, Mycophenolate; Mofetil, Mycophenolate; Mycophenolate, Sodium; RS61443; -Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-

Networked: 3948 relevant articles (461 outcomes, 474 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Chan, Tak Mao: 13 articles (03/2022 - 12/2007)
2.	Mok, Chi Chiu: 12 articles (12/2022 - 09/2002)
3.	Jayne, David: 11 articles (01/2021 - 01/2005)
4.	Storb, Rainer: 11 articles (01/2021 - 03/2002)
5.	Acharya, Nisha R: 10 articles (01/2022 - 03/2012)
6.	van Gelder, Teun: 10 articles (01/2022 - 03/2003)
7.	Sandmaier, Brenda M: 10 articles (01/2021 - 03/2002)
8.	Rostaing, Lionel: 10 articles (01/2019 - 09/2004)
9.	Ginzler, Ellen M: 10 articles (01/2016 - 11/2005)
10.	Oellerich, Michael: 10 articles (01/2014 - 05/2002)

Related Diseases

1.	Lupus Nephritis 07/01/2023 - "Proliferative lupus nephritis was assumed and mycophenolate mofetil was introduced, with sustained complete remission over a 33-month follow-up. " 01/01/2012 - "Clinical trials revealed a high efficacy of mycophenolate mofetil (MMF)in inducing and maintaining remission in patients with class III-V-lupus nephritis. " 11/01/2005 - "Short-term to intermediate-term, randomized controlled trials have shown that mycophenolate mofetil is a good option for the induction and maintenance of remission in lupus nephritis patients. " 11/24/2005 - "Since anecdotal series and small, prospective, controlled trials suggest that mycophenolate mofetil may be effective for treating lupus nephritis, larger trials are desirable. " 12/01/2017 - "Mycophenolic acid (MPA) provides effective treatment for lupus nephritis patients. "
2.	Nephrotic Syndrome (Syndrome, Nephrotic) 03/01/2016 - "To establish the efficacy of mycophenolate mofetil (MMF) in steroid dependent nephrotic syndrome and to determine the predictive factors for a good response. " 12/01/2018 - "Mycophenolate mofetil for sustained remission in nephrotic syndrome." 02/01/2017 - "Overall condition improvement in a rat model of nephrotic syndrome treated with CellCept nanoliposomes." 03/01/2022 - "Mycophenolate mofetil is effective for the treatment of pediatric idiopathic nephrotic syndrome (INS). " 10/07/2016 - "Therapeutic drug monitoring leading to individualized dosing may improve the efficacy of mycophenolate mofetil in steroid-dependent nephrotic syndrome. "
3.	Proteinuria 06/01/2004 - "The proteinuria improved dramatically following treatment with mycophenolate mofetil. " 01/01/2009 - "The patient was treated with mycophenolate mofetil (1.5 g/day) with a significant improvement in proteinuria." 10/01/2022 - "Remission can be achieved in patients with IGAVN and nephrotic-range proteinuria using mycophenolate mofetil-based immunosuppression. " 05/01/2012 - "Our aim was to evaluate the efficacy of mycophenolate mofetil (MMF) for treating pediatric patients with HSPN and nephrotic-range proteinuria. " 09/01/2023 - "Also, Mycophenolic Acid has discontinued for her 5 months ago due to the reduction of proteinuria and the control of the disease. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 07/01/2017 - "Background Mycophenolate mofetil has recently been reported to be effective against systemic lupus erythematosus. " 01/01/2015 - "Mycophenolate mofetil (MMF) has recently been reported to be effective in the treatment of systemic lupus erythematosus (SLE). " 04/01/2012 - "Mycophenolate mofetil (MMF) has been reported recently to be effective in the treatment of systemic lupus erythematosus (SLE). " 10/01/2011 - "Mycophenolate mofetil (MMF) is an immunomodulatory drug shown to be effective in the treatment of systemic lupus erythematosus. " 04/01/2009 - "Mycophenolate mofetil (MMF) is effective in the treatment of patients with active systemic lupus erythematosus (SLE). "
5.	Pemphigus (Pemphigus Vulgaris) 12/01/2009 - "Mycophenolate sodium appears to be an effective and safe alternative in the treatment of pemphigus vulgaris." 07/01/1999 - "Is mycophenolic acid effective for the treatment of pemphigus?" 08/01/2010 - "Non-blinded trials of pemphigus vulgaris suggest that mycophenolate mofetil (MMF) may be beneficial. " 03/01/2008 - "The present study describes our experience of the adjuvant use of mycophenolate mofetil in the management of 31 patients with pemphigus vulgaris as an initial treatment. " 01/01/2002 - "[Open trial of mycophenolate mofetil in the treatment of resistant pemphigus vulgaris]."

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4.	Adrenal Cortex Hormones (Corticosteroids)
5.	Steroids
6.	Tacrolimus (Prograf)
7.	Rituximab (Mabthera)
8.	Immunosuppressive Agents (Immunosuppressants)
9.	Prednisone (Sone)
10.	Methotrexate (Mexate)

Related Therapies and Procedures

1.	Therapeutics
2.	Kidney Transplantation
3.	Transplantation
4.	Liver Transplantation
5.	Hematopoietic Stem Cell Transplantation