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Mutism (Selective Mutism)

The inability to generate oral-verbal expression, despite normal comprehension of speech. This may be associated with BRAIN DISEASES or MENTAL DISORDERS. Organic mutism may be associated with damage to the FRONTAL LOBE; BRAIN STEM; THALAMUS; and CEREBELLUM. Selective mutism is a psychological condition that usually affects children characterized by continuous refusal to speak in social situations by a child who is able and willing to speak to selected persons. Kussmal aphasia refers to mutism in psychosis. (From Fortschr Neurol Psychiatr 1994; 62(9):337-44)
Also Known As:
Selective Mutism; Elective Mutism; Kussmaul's Aphasia; Mutism, Conversion; Mutism, Elective; Mutism, Organic; Mutism, Selective; Mutism, Voluntary; Aphasia, Kussmaul; Aphasia, Kussmaul's; Conversion Mutism; Conversion Mutisms; Elective Mutisms; Kussmauls Aphasia; Mutisms; Mutisms, Conversion; Mutisms, Elective; Mutisms, Organic; Mutisms, Voluntary; Organic Mutism; Organic Mutisms; Voluntary Mutism; Voluntary Mutisms; Kussmaul Aphasia
Networked: 191 relevant articles (24 outcomes, 24 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Catatonia
2. Psychotic Disorders (Schizoaffective Disorder)
3. Mutism (Selective Mutism)
4. Medulloblastoma
5. Seizures (Absence Seizure)

Experts

1. Kristensen, Hanne: 2 articles (11/2021 - 07/2012)
2. Vincent, Angela: 2 articles (10/2016 - 10/2010)
3. Manassis, Katharina: 2 articles (06/2016 - 01/2013)
4. Oerbeck, Beate: 2 articles (06/2016 - 07/2012)
5. Figlerowicz, Magdalena: 1 article (04/2022)
6. Lubarski, Karol: 1 article (04/2022)
7. Mania, Anna: 1 article (04/2022)
8. Mazur-Melewska, Katarzyna: 1 article (04/2022)
9. Michalak, Sławomir: 1 article (04/2022)
10. Osztynowicz, Krystyna: 1 article (04/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mutism:
1. Fluoxetine (Prozac)FDA LinkGeneric
2. SteroidsIBA
3. Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA
4. Amobarbital (Amsal)IBA
5. Zolpidem (Ambien)FDA LinkGeneric
6. Aripiprazole (Abilify)FDA Link
7. AntibodiesIBA
8. Lorazepam (Ativan)FDA LinkGeneric
02/01/1986 - "Lorazepam for a short-term alleviation of mutism."
05/01/2007 - "Catatonic mutism after liver transplant rapidly reversed with lorazepam."
01/01/2023 - "While initially, the patient appeared to have a positive response to lorazepam, she became increasingly catatonic with minimal oral intake, mutism, and urinary retention. "
01/01/2022 - "In recent years, there has been a call to move catatonia from a classifier to a diagnosis of its own in the DSM-5.1,2 Catatonia is often underdiagnosed in the hospital and carries with it substantial morbidity and mortality.3 Malignant catatonia, characterized by autonomic instability, hyperactivity, mutism, and stuporous exhaustion, is a medical emergency requiring intensive care.4 Early diagnosis and treatment are imperative, as untreated malignant catatonia may be fatal in up to 10% to 20% of cases, sometimes only days from onset.5 The combination of lorazepam and electroconvulsive therapy (ECT) is a safe and effective treatment for catatonia in both adults and children, although the body of literature pertaining to children remains limited.6,7 In addition, there are multiple case reports of improvement in catatonia with ECT regardless of etiology.8 However, laws in some US states prohibit ECT's use despite evidence of its effectiveness and safety in children and adolescents.9 Here, we describe a case presentation that was both prolonged and complicated by state laws pertaining to the use of ECT in children and adolescents."
05/01/2012 - "This study identifies that longer duration of illness, presence of catatonic sign of mutism and certain specific phenomena like third-person auditory hallucinations and made phenomena predicted poor response to lorazepam in catatonia. "
9. N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
10. N-Methylaspartate (NMDA)IBA

Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Critical Care (Surgical Intensive Care)
4. Aftercare (After-Treatment)
5. Patient-Controlled Analgesia (Analgesia, Patient Controlled)