Mutagens

04/01/2014 - "To increase the efficacy of currently used anti-cancer genotoxins, one of the current efforts is to find agents that can sensitize cancer cells to genotoxins so that the efficacious doses of genotoxins can be lowered to reduce deleterious side-effects. "
09/01/2011 - "To increase the efficacy of currently used anti-cancer genotoxins, a combination use of different drugs is a potential new therapeutical tool. "
10/04/2004 - "Nevertheless, our results suggest that research on the mutagen sensitivity and efficacy of DNA repair could impact the development of new diagnostic and screening strategies as well as indicate new targets to prevent and cure cancer. "
02/01/2008 - "The investigation of BLM sensitivity on cancer- or disease-free subjects and not occupationally exposed to known mutagen represents the strengths of the present study, as the detection of genetic damage is not biased by any disease- and occupational-related factor. "
01/01/2003 - "The yeast assay could hold promise for the identification of mutagens implicated in human cancer if the p53 mutational spectra obtained with this assay would match human tumor mutation data. "

05/01/2001 - "Chromosome aberration assays in Pisum for the study of environmental mutagens."
06/01/1998 - "Chromosome aberration assays in Crepis for the study of environmental mutagens."
03/01/1998 - "The study comprised 100 subjects, all medical staff occupationally exposed to X-rays, who were re-examined for unstable chromosomal aberrations after 3 months (12 subjects), 6 months (31 subjects), 9 months (13 subjects), 12 months (21 subjects), over 24 months (14 subjects), and over 36 months (9 subjects) controls were 60 subjects who were not exposed to ionizing radiation or chemical mutagens at their workplaces. "
10/01/1993 - "In addition to the analysis of spontaneous and clastogen-induced chromosome aberrations, this study also included classical karyotype analysis and scoring of sister chromatid exchanges (SCE) in some of the patients. "
01/01/1990 - "However, in our MDS patients these so called "mutagen-associated" chromosome abnormalities were significantly more frequent than in all studies published so far. "

02/01/1994 - "Study of the molecular basis for Legionella pneumophila pathogenicity would be facilitated with an efficient mutagen that can not only mark genomic mutations, but can also be used to reflect gene expression during macrophage infection. "
05/02/2023 - "Pre-neoplastic cells could appear as a result of various pro-carcinogenic events, among which, are infections with bacteria that produce genotoxins that generate cells with high genetic instability. "
02/10/2023 - "This review presents the cellular responses of infection with the genotoxins-producing E. "
01/01/2023 - "Thus, UPEC infection acts as an epi-mutagen reprogramming the urothelial epigenome, leading to urothelial-intrinsic remodelling and training of the innate response to subsequent infection."
01/01/2022 - "Our findings elucidate the mechanisms through which genotoxins shape microbial communities and provide a platform for probing the larger role of enteric multibacterial interactions regarding infection and disease outcomes."

12/01/2023 - "Studies have associated bacterial generation of genotoxins with the occurrence of TMPRSS2-ERG gene fusions, a common, early oncogenic event during prostate carcinogenesis. "
12/15/2012 - "Nf1 heterozygosity confers broad susceptibility to genotoxin-induced tumorigenesis, and this paradigm serves as an experimental platform for future studies of SMNs."
04/10/2011 - "In conclusion, we suggest that this in vitro model may provide the feasibility for future studies on the molecular basis of pancreatic ductal cell carcinogenesis caused by dietary mutagens."
10/01/2002 - "Regarding risk factors, studies of inherited susceptibility and constitutive polymorphisms in genes pertinent to carcinogenesis (for example, DNA repair and detoxification genes and mutagen sensitivity) have revealed provocative findings. "
09/01/2022 - "The mechanistic basis of inflammatory response and oxidative damage triggered by mutagens in tumorigenesis has also been highlighted. "

05/24/2023 - "The cytokinesis-block micronucleus cytome assay (CBMN), a well-established marker assay for chromosomal mutagen sensitivity, was applied in this study enrolling breast cancer patients and age and sex-matched controls. "
10/01/2011 - "The results from this study provide strong support for the hypotheses that high red meat intake and meat-derived mutagen exposure may be associated with an increase in breast cancer risk."
10/01/2011 - "Previous studies of the association of meat intake and meat-derived mutagen exposure with breast cancer risk have produced inconsistent results. "
10/01/2011 - "Well-done meat intake and meat-derived mutagen exposures in relation to breast cancer risk: the Nashville Breast Health Study."
01/01/2002 - "Fluid obtained by ductal lavage may allow for more detailed studies of the role of mutagens in breast cancer."