HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Muscle Cramp (Cramp)

A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)
Also Known As:
Cramp; Cramps; Cramp, Muscle; Muscle Cramps; Muscular Cramp; Cramp, Limb; Cramp, Muscular; Cramps, Limb; Cramps, Muscle; Cramps, Muscular; Limb Cramps; Muscular Cramps; Limb Cramp
Networked: 1781 relevant articles (171 outcomes, 200 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Pain (Aches)
2. Fibrosis (Cirrhosis)
3. Muscle Cramp (Cramp)
4. Hypotension (Low Blood Pressure)
5. Spasm (Spasms)

Experts

1. Gallo, Richard L: 20 articles (06/2015 - 04/2003)
2. Sun, Jia: 13 articles (01/2022 - 08/2015)
3. Agerberth, Birgitta: 10 articles (01/2021 - 06/2006)
4. Finsterer, Josef: 8 articles (01/2021 - 07/2006)
5. Wang, Ji Ming: 8 articles (01/2021 - 06/2013)
6. Miller, Kevin C: 8 articles (01/2020 - 09/2009)
7. Diana, Julien: 7 articles (01/2022 - 01/2013)
8. Pan, Li-Long: 7 articles (01/2022 - 01/2019)
9. Chen, Keqiang: 7 articles (01/2021 - 06/2013)
10. Gong, Wanghua: 7 articles (01/2021 - 06/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Muscle Cramp:
1. Quinine (Quinson)FDA Link
2. MagnesiumIBA
3. Carnitine (L-Carnitine)FDA LinkGeneric
4. CathelicidinsIBA
5. TaurineFDA Link
6. shakuyaku-kanzoh-tohIBA
7. Antimicrobial PeptidesIBA
8. Acetaminophen (Paracetamol)FDA LinkGeneric
9. Mexiletine (Mexitil)FDA LinkGeneric
10. SodiumIBA

Therapies and Procedures

1. Therapeutics
2. Renal Dialysis (Hemodialysis)
3. Aftercare (After-Treatment)
12/04/2020 - "In one study, results indicated that women may be more likely to report never having any leg cramps after treatment (risk ratio (RR) 5.66, 95% confidence interval (CI) 1.35 to 23.68, 1 trial, 69 women, low-certainty evidence); whilst fewer women may report having twice-weekly leg cramps (RR 0.29, 95% CI 0.11 to 0.80, 1 trial, 69 women); and more women may report a 50% reduction in number of leg cramps after treatment (RR 1.42, 95% CI 1.09 to 1.86, 1 trial, 86 women, low-certainty evidence). "
08/11/2015 - "Outcomes that showed differences were: frequency of leg cramps after treatment: never, and twice a week (risk ratio (RR) 5.66, 95% confidence interval (CI) 1.35 to 23.68, one trial, 69 women, evidence graded low; RR 0.29, 95% CI 0.11 to 0.80, one trial, 69 women), and frequency of leg cramps: 50% reduction in number of leg cramps after treatment (RR 1.42, 95% CI 1.09 to 1.86, one trial, 86 women, evidence graded low). "
07/01/2021 - "The frequency of leg cramps after treatment was not decreased in the treatment group compared to the control group (WMD = -0.47, 95% CI: -1.14-0.20, P = 0.167). "
07/01/2021 - "We summarized the weighted mean difference (WMD) with 95% CIs for "the frequency of leg cramps after treatment", and summarized the odds ratio (OR) with 95% confidence intervals (CIs) for "recovery from leg cramps" and "side effects". "
01/01/2021 - "Muscle cramp scores (frequency×intensity) decreased in seven patients by weeks 4 and 8 after treatment initiation. "
4. Oral Administration
5. Transcutaneous Electric Nerve Stimulation (TENS)