Muscimol

A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.

Also Known As:

Networked: 610 relevant articles (41 outcomes, 36 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Ludvig, Nandor: 7 articles (02/2013 - 04/2009)
2.	Moshé, Solomon L: 6 articles (12/2014 - 08/2003)
3.	Kuzniecky, Ruben I: 6 articles (07/2012 - 04/2009)
4.	Tang, Hai M: 6 articles (07/2012 - 04/2009)
5.	Colombari, Eduardo: 5 articles (01/2013 - 04/2006)
6.	Devinsky, Orrin: 5 articles (07/2012 - 04/2009)
7.	Parent, Marise B: 5 articles (03/2010 - 05/2003)
8.	Walf, Alicia A: 5 articles (09/2008 - 01/2006)
9.	Frye, Cheryl A: 5 articles (09/2008 - 01/2006)
10.	Takakura, Ana C: 4 articles (07/2014 - 02/2011)

Related Diseases

1.	Seizures (Seizure) 04/25/2011 - "The duration of Ach-induced EEG seizures was measured in each experimental session to assess the antiepileptic efficacy of muscimol, while the rat's behavior was also monitored. " 03/02/2012 - "Electrophysiological and behavioral studies have demonstrated that muscimol administered through the cranial meninges can prevent focal neocortical seizures. " 01/01/2001 - "In the present study, we first confirmed that bilateral injection of muscimol (700 pmol/side) in the substantia nigra had no effect in Wistar rats with audiogenic seizures (Wistar AS). " 06/01/1992 - "Since previous work had suggested that the anticonvulsant effect of intranigral muscimol depended on the particular experimental seizure used, three different experimental seizures were used in the present study to evaluate the effects of BMI infusion into the tectum. " 01/01/1987 - "Since previous studies have shown that similar infusions of muscimol are anticonvulsant in adults and proconvulsant in rat pups, our results suggest that the nigrostriatal pathway may play an important role in mediating the nigral effects on seizures."
2.	Hyperalgesia 01/01/2014 - "In addition, the efficacy of different doses of muscimol did not have difference on thermal hyperalgesia (df: 24, 5; F= 1.52; p= 0.24), mechanical hyperalgesia (df: 24, 5; F= 0.3; p= -0.75), cold allodynia (df: 24, 5; F= 0.8; p= -0.56), and mechanical allodynia (df: 24, 5; F= 1.75; p= 0.86). " 01/01/2014 - "Muscimol with the dose of 0.01 µg in 15 minutes caused to improve the thermal hyperalgesia (df: 24, 5; F= 6.6; p<0.001), mechanical hyperalgesia (df: 24, 5; F= 7.8; p<0.001), cold allodynia (df: 24, 5; F= 6.96; p<0.001), and mechanical allodynia (df: 24, 5; F= 15.7; p<0.001). " 01/01/2014 - "Furthermore, in the L5 SNL rats, 20 μg Muscimol injected immediately after injury caused a long-lasting attenuation of mechanical allodynia (P<0.05), whereas the thermal hyperalgesia was not alleviated (P>0.05). " 03/01/2012 - "Dorsal root ganglion application of muscimol prevents hyperalgesia and stimulates myelin protein expression after sciatic nerve injury in rats." 06/01/2005 - "Mechanical hyperalgesia was attenuated only by the highest dose of muscimol. "
3.	Ischemia 07/01/1998 - "The [3H]muscimol binding sites were significantly reduced four weeks after ischemia in the motor cortex, hindlimb representation area and exofocal parts of the primary and secondary somatosensory cortices of both hemispheres. " 02/01/1987 - "In the superolateral convexities of the frontal cortices, [3H]muscimol binding was increased in 60% of the animals killed 3 days after ischemia, and decreased in 67% of the animals killed 27 days after ischemia. " 03/17/2003 - "Transient focal ischemia caused a significant reduction of [(3)H]muscimol binding to GABA(A) receptors within the ischemic cortical penumbra of placebo-treated rats. " 10/01/1993 - "In this study, we looked at the protective effects of muscimol, a GABA A agonist in a gerbil model of repetitive forebrain ischemia. " 01/01/1994 - "Focal ischemia caused a moderate to severe delay in the acquisition of visual-spatial information, which was completely eliminated by the combination treatment but only partially ameliorated with MK-801 or muscimol alone. "
4.	Hypercapnia 03/01/2001 - "Muscimol dialysis (10 and 40 mM) had no effect on eupnea but caused a significant reduction in the response to hypercapnia during both wakefulness (34.8 +/- 8.7 and 30.7 +/- 10.1%, respectively) and sleep (36.7 +/- 6.7 and 49.5 +/- 8.9%, respectively). " 04/15/2006 - "Muscimol did not change the threshold and sensitivity of RTN neurons to hyperoxic hypercapnia nor their activation by peripheral chemoreceptor stimulation. " 10/01/2000 - "Muscimol dialysis caused a 32.4+/-10.4% reduction in MA with a significant downward displacement of the response to hypercapnia with no significant effect on the slope. " 10/01/2000 - "In the RVM of decerebrate piglets 2-15 days of age, we studied the effects of electrolytic lesions (n=7) or microdialysis of muscimol (n=15), a GABAA receptor agonist, on ventilatory output and the response to hypercapnia. " 07/01/2014 - "Muscimol injection in the KF reduced the increase in ventilation produced by hypoxia (8% O2) (1,827 ± 61 vs. saline: 3,179 ± 325 ml·kg(-1)·min(-1)) or hypercapnia (7% CO2) (1,488 ± 277 vs. saline: 3,539 ± 374 ml·kg(-1)·min(-1)) in unanesthetized rats. "
5.	Anoxia (Hypoxia) 01/01/2015 - "There was a significant attenuation in these responses to hypobaric hypoxia (a) after lesioning posterior hypothalamus and (b) after chronic infusion of GABAA receptor agonist muscimol into posterior hypothalamus. " 03/01/2012 - "Heart rate increased during hypoxia and was greatest in muscimol-injected pups. " 09/01/2002 - "Changes in the activity of muscimol under hypoxia may have significant clinical implications." 09/01/2002 - "In conclusion, muscimol in hypoxia-exposed group of rats exerted beneficial effect on consolidation in passive avoidance situation and exerted anxiolytic activity. " 09/01/2002 - "In the elevated "plus" maze test, treatment of rats with muscimol after hypoxia significantly prolonged the time spent in open arms and increased the number of entries into open arms, while shortened the time spent in closed arms. "

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Related Therapies and Procedures

1.	Injections
2.	Drug Therapy (Chemotherapy)
3.	Spinal Injections
4.	Catheters
5.	Analgesia