Multiple Organ Failure (MODS)

A progressive condition usually characterized by combined failure of several organs such as the lungs, liver, kidney, along with some clotting mechanisms, usually postinjury or postoperative.

Also Known As:

Networked: 2487 relevant articles (109 outcomes, 223 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sepsis (Septicemia)
2.	Septic Shock (Toxic Shock Syndrome)
3.	Multiple Organ Failure (MODS)
4.	Wounds and Injuries (Trauma)
5.	Infection

Experts

1.	Cuzzocrea, Salvatore: 20 articles (09/2011 - 10/2002)
2.	Moore, Ernest E: 19 articles (02/2013 - 02/2003)
3.	Gando, Satoshi: 16 articles (07/2013 - 08/2002)
4.	Mazzon, Emanuela: 15 articles (09/2011 - 10/2002)
5.	Di Paola, Rosanna: 13 articles (09/2011 - 11/2003)
6.	Carcillo, Joseph A: 12 articles (10/2015 - 02/2002)
7.	Cuschieri, Joseph: 12 articles (02/2013 - 02/2002)
8.	Thiemermann, Christoph: 11 articles (01/2015 - 01/2002)
9.	Hayakawa, Mineji: 10 articles (12/2012 - 08/2002)
10.	Maier, Ronald V: 10 articles (03/2012 - 02/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multiple Organ Failure:

1.	CytokinesIBA 01/01/2007 - "Our data indicate that CPFA combined with CVVH is an effective and safe method to improve the prognosis of MODS patients with ALF, the mechanism of which may be related to its effective removal of inflammatory cytokines." 09/01/2015 - "PD improved organ function, prolonged survival time, and reduced MODS incidence and serum levels of AOPPs and proinflammatory cytokines. " 04/01/2012 - "Here we present the Pathway Semantics Algorithm (PSA), an algebraic process of node and edge analyses of evoked biological pathways over time for in silico discovery of biomedical hypotheses, using data from a prospective controlled clinical study of the role of cytokines in multiple organ failure (MOF) at a major US trauma center. " 09/01/2003 - "We initiated MARS therapy (extracorporeal liver support utilizing albumin dialysis) with intention to positively influence the organ functions in his MODS on the basis of recently published studies which suggested a positive impact of MARS in multiorgan failure secondary to respiratory illnesses and the possible influence on inflammatory mediators and cytokines. " 02/21/2003 - "In the present study, we investigated plasma levels of pro- and anti-inflammatory cytokines in survivors and non-survivors from MODS in the early postoperative course following open heart surgery. "
2.	ZymosanIBA 06/01/2002 - "In conclusion, TNF-deficient mice exhibit significantly improved morbidity and mortality during zymosan-induced MODS. " 06/01/2002 - "Improved survival of TNF-deficient mice during the zymosan-induced multiple organ dysfunction syndrome." 09/01/2011 - "The aim of this study was to evaluate the possible role of glucocorticoid-induced TNFR-related (GITR) on zymosan-induced MODS. " 07/01/2011 - "The aim of this study was to investigate the effect of HBO exposure on TLR2 and TLR4 signal transduction and organ dysfunction during MODS induced by zymosan in the rat. " 03/01/2015 - "In conclusion, the lack of 5-HT by genetic knockout or by pharmacologic inhibition of the TPH1 enzyme significantly attenuated zymosan-induced MODS. "
3.	Anti-Bacterial Agents (Antibiotics)IBA 03/01/2011 - "He eventually died of multiple organ failure due to multi-antibiotics resistance. " 08/01/2009 - "In spite of administration of broad-spectrum antibiotics and repeated surgical removal of necrotic tissue the patient died of multiple organ failure. " 09/30/2003 - "Indeed, in some individuals, an enhanced inflammatory response may lead to multiple organ failure despite early and appropriate use of antibiotics. " 06/01/2000 - "Although potent antibiotics and catecholamine were administered, he died of multiple organ failure 29 hours after the operation. " 05/01/1995 - "Despite the development of better resuscitation, more powerful antibiotics, and more sophisticated methods for organ support, our ability to rescue patients from established MODS has not improved significantly since the syndrome was first described two decades ago. "
4.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/01/2015 - "[Modulation of endothelial progenitor cells by tumor necrosis factor-α in multiple organ dysfunction syndrome in swine]." 09/01/2009 - "Phosphorylation of p38MAPK was obviously increased in extent, which enhanced gene expression of TNF-alpha and then secretion of TNF-alpha by the peripheral blood mononuclear cell in MODS, and the differences were statistically significant compared with that of control group (P<0.05 or P<0.01). " 07/01/2008 - "Under the normal physiologic condition, TNF-alpha and NO moved steadily without chaotic properties; while under the pathologic condition of MODS, they manifest relatively complicated chaotic properties. " 06/01/2007 - "To remove endotoxin and TNF-alpha from patients with MODS, the adsorption method has proven to be most effective. " 06/01/2007 - "Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that plays a crucial role in the pathogenesis of multiple organ dysfunction syndrome. "
5.	OxygenIBA 04/01/2011 - "This study compared the parameter estimates of pulmonary oxygen uptake (VO(2p)), heart rate (HR) and muscle deoxygenation (Δ[HHb]) kinetics when several moderate-intensity exercise transitions (MODs) were performed during a single visit versus several MODs performed during separate visits. " 07/08/1998 - "At study entry (day 9 [SD, 3] of ARDS), the 2 groups had similar LIS, ratios of PaO2 to fraction of inspired oxygen (FIO2), and MODS scores. " 06/01/2013 - "Tissue oxygen saturation has been predicative of onset of multiple organ dysfunction syndrome. " 10/01/2011 - "The physiological and biochemical abnormalities that constitute multiple organ failure represent cellular perturbations that, importantly, need to be reconciled with a lack of significant cell death together with availability but impaired utilization of oxygen. " 08/01/2011 - "A reliable, continuous method of monitoring splanchnic organ oxygen saturation could allow for the early detection of malperfusion, and may prevent the onset of multiple organ failure. "
6.	C-Reactive ProteinIBA 04/01/2007 - "Treated patients had significant reduction in C-reactive protein levels, and by day 7 had lower LIS and multiple organ dysfunction syndrome scores. " 05/01/2000 - "The PaO2/FiO2 ratio improved significantly within 3 days after the start of steroid therapy, and MODS and C-reactive protein decreased concurrently. " 06/01/2014 - "In addition, 65 age- and sex-matched patients with pronounced MODS were assigned for comparison of autonomic function and C-reactive protein in patients with CHF or MODS, respectively. " 04/01/2013 - "The C-reactive protein (CRP) index, acute physiology and chronic health evaluation II (APACHE II) score, mechanical duration of ventilation, mortality rate, incidence of multiple organ failure, and usage of continuous renal replacement therapy were evaluated. " 02/01/2005 - "By Study Day 8, treated patients had, compared with control subjects, a significant improvement in Pa(O(2)):FI(O(2)) (p = 0.002) and chest radiograph score (p < 0.0001), and a significant reduction in C-reactive protein levels (p = 0.01), MODS score (p = 0.003), and delayed septic shock (p = 0.001). "
7.	MethylprednisoloneFDA LinkGeneric 07/08/1998 - "Changes observed by study day 10 for methylprednisolone vs placebo were as follows: reduced LIS (mean [SEM], 1.7 [0.1] vs 3.0 [0.2]; P<.001); improved ratio of PaO2 to FIO2 (mean [SEM], 262 [19] vs 148 [35]; P<.001); decreased MODS score (mean [SEM], 0.7 [0.2] vs 1.8 [0.3]; P<.001); and successful extubation (7 vs 0; P=.05). " 02/01/2001 - "Although high-dose methylprednisolone therapy was continued, her white blood cell count further decreased to 0.3 x 10(9)/L, and the patient died of multiple organ failure on day 29 post-PBSCT. " 09/01/1989 - "The patient did not respond to high-dose methylprednisolone therapy, and died of multiple organ failure on the 18th day after the operation." 11/01/1998 - "Among nonimprovers, those randomized to prolonged methylprednisolone treatment had a rapid and significant reduction in plasma and BAL aminoterminal propeptide levels and similar changes in lung injury and MODS scores. " 07/08/1998 - "In this study, prolonged administration of methylprednisolone in patients with unresolving ARDS was associated with improvement in lung injury and MODS scores and reduced mortality."
8.	Protein CIBA 01/01/2012 - "Sequential measurements of cfDNA suggested that ICU mortality may be predicted within 24 hours of study inclusion, and that the predictive power of cfDNA may be enhanced by combining it with protein C levels or MODS scores. " 07/01/2015 - "Levels of antithrombin (P = .026) and protein C (P = .035) were significantly lower in patients with MODS. " 01/01/2012 - "The serial data suggest that the combination of cfDNA with protein C and MODS scores may yield even stronger predictive power. " 01/01/2007 - "Drotrecogin alpha (activated) (DAA), or recombinant human activated protein C, is a new treatment in sepsis-induced multiple organ failure, leading to significant reduction in the mortality rate, thanks to its anticoagulant properties. " 12/01/2008 - "Improvements in ICU care in the last 10 years (e.g., tight glycemic control, activated protein C, fewer transfusions causing fewer nosocomial infections) may have decreased the incidence, magnitude, and mortality of MODS, as hypothesized in this study. "
9.	Interleukin-8 (Interleukin 8)IBA 03/01/2004 - "Mean values of IL-8 were 1.3-fold higher in non-survivors (p<0.05), and 60-fold higher in MODS group (p<0.01). " 10/01/1998 - "Increased serum interleukin-8: correlation with poor prognosis in patients with postoperative multiple organ failure." 04/01/1994 - "In septic patients, high amounts of circulating IL-8 concentrations correlate with fatal outcome, whereas only low plasma concentrations of IL-8 are present in patients with nonseptic, multiple organ failure. " 04/01/1994 - "Although the mortality rate of nonseptic, multiple organ failure patients was 92%, low plasma concentrations of IL-8 were found (78 +/- 34 pg/mL), while high plasma concentrations were measured in septic, multiple organ failure patients (mortality rate 69%) who were sampled at a similar stage. " 04/01/1994 - "We investigated whether the presence of measurable IL-8 in plasma was associated with the clinical status of severely ill septic or nonseptic patients susceptible to the development of multiple organ failure. "
10.	Proteins (Proteins, Gene)IBA 10/01/2013 - "Continuous blood purification ameliorates endothelial hyperpermeability in SAP patients with MODS by regulating tight junction proteins via ROCK." 04/01/2011 - "Further studies will be required to determine if the proteins identified participate in the pathogenesis of multiple organ failure and if they can be used as diagnostic markers." 05/01/2014 - "Compared with the MODS model group, the apoptosis quantity of SMCs and the expression of Bax and Cyt c proteins significantly decreased, and the expression of Bcl-2 protein significantly increased in the DG group (allP <0.01). " 10/01/2013 - "However, the effect of CBP on the change of tight junction proteins in SAP patients with MODS was still unknown. " 01/01/2011 - "Functional clustering of proteins revealed changes arising from several global classes that give novel insight into fundamental mechanisms of MODS. "

Therapies and Procedures

1.	Resuscitation 01/01/2012 - "For the late resuscitation studies (n = 3), there was statistically significant difference [P = 0.05, I (2)=66%], and there was no significant effect on mortality (OR = 0.89, 95%CI 0.52-1.54, P = 0.68) and incidence of MODS (OR = 0.43, 95%CI 0.17-1.08, P = 0.07). " 04/01/2013 - "In the end, 2 patients (33.3%) died from multiple-organ failure, despite intensive resuscitation. " 01/01/2008 - "The high prevalence of multiple organ failure at diagnosis and the high mortality in the first 48 h suggests delays in diagnosis, in initial resuscitation, and/or in initiating appropriate antibiotic treatment." 12/01/2007 - "An early and adequate resuscitation with goal-directed therapy enabled the reversion of the multiple organ failure syndromes and a favorable outcome, despite the severity of the disease." 06/01/2006 - "One newborn was asystolic despite resuscitation and died of multiple organ failure. "
2.	Plasma Exchange 05/01/2015 - "Therapeutic plasma exchange as a strategy to reverse multiple organ dysfunction syndrome in patients receiving extracorporeal life support." 07/01/2002 - "Despite the treatment of successive plasma exchange and steroid pulse therapy, he eventually died by multiple organ failure. " 01/01/1990 - "Plasma exchange might be of value as adjunctive therapy where overwhelming septicaemia occurs with multiple organ failure." 01/01/1990 - "Two patients with multiple organ failure, septicaemia and a deteriorating clinical course were treated by plasma exchange in addition to standard supportive measures. " 01/01/1990 - "Multiple organ failure--a role for plasma exchange?"
3.	Debridement 01/01/2005 - "The diagnosis and treatment of these conditions is best accomplished in a regional burn center in which management of multiple organ failure can be conducted with aggressive debridement and fasciotomy of the necrotic skin. " 07/01/2014 - "His admission was punctuated by multiple surgical debridements and a prolonged intensive care stay due to multiple organ failure. " 09/28/2009 - "The patient eventually succumbed to multiple organ failure despite surgical debridement and drainage, together with aggressive antibiotic therapy and nutritional support. " 02/01/2012 - "Intra-abdominal sepsis leading to multiple organ failure accounts for most of the late deaths, indicating the importance of early haemodynamic stabilization, adequate debridement of devitalized tissue and wide drainage. " 03/01/2005 - "The patient underwent emergency surgery with debridement of all necrotic tissue, exploratory laparotomy, sigmoidectomy and derivative colostomy, but due to her advanced age and multiple organ failure, the outcome was fatal."
4.	Renal Replacement Therapy (Therapies, Renal Replacement) 10/01/1993 - "The improved understanding of the multiple organ failure syndrome and the pathophysiology of the septic syndrome, suggest today newer indications for continuous renal replacement therapies. " 11/01/2014 - "Continuous renal replacement therapy in children with multiple organ dysfunction syndrome: a case series." 09/01/2012 - "Of 1650 children undergoing cardiac surgery, 81 (4.9%) required continuous renal replacement therapy, 65 of whom (80.2%) presented multiple organ failure. " 06/28/2011 - "[Effect of continuous renal replacement therapy started at different time on patients with multiple organ dysfunction syndrome]." 09/01/2006 - "Renal replacement therapy is necessary mainly in the setting of multiple organ failure on intensive care units with few patients surviving to require long term renal replacement therapy. "
5.	Renal Dialysis (Hemodialysis) 10/01/2001 - "The objective was to study the effects of daily intermittent on-line predilution hemodiafiltration (IHDF) on laboratory parameters, and on multiple organ dysfunction score (MODS), compared with intermittent hemodialysis (IHD). " 01/01/2008 - "All of these patients died of multiple organ failure or required permanent hemodialysis within 1 year after the start of cyclic VAD. " 03/01/2005 - "Extracorporeal life support and continuous hemodialysis were initiated, but the patient died with multiple organ failure on 5th postoperative day. " 02/01/2003 - "The experience in 17 MODS cases with ARF treated with intermittent hemodialysis (IHD) in our hospital before October 1999 was present. " 11/01/1990 - "3 cases died in multiple organ failure, included a case treated by hemodialysis. "