Morphine Dependence

02/01/2009 - "Notably, in the spontaneous withdrawal study, AV411 treatment was delayed relative to the start of the morphine regimen so to also test whether AV411 could still be effective in the face of established morphine dependence, which it was. "
07/01/2011 - "It suggests that WG extract may be effective for inhibiting the behavioral effects of morphine by possibly modulating the central dopaminergic system and that WG might be a useful resource to develop an agent for preventing and treating morphine addiction."
01/01/1991 - "It was concluded that morphine experience enhances the reinforcing efficacy of morphine and broadens the conditions under which the drug is reinforcing; thus it possibly increases morphine abuse potential."
01/15/2015 - "We conclude that regular swimming exercise reduces the severity of morphine dependence and voluntary morphine consumption with reducing anxiety and depression in morphine-dependent and withdrawn rats. "
12/01/2015 - "Therefore, this study investigated TH changes in dopaminergic neurons of the ventral tegmental area (VTA) and substantia nigra (SN), as well as the morphine effects on dopaminergic neurons induced by different durations of morphine dependence. "

10/25/2005 - "This study was to investigate the role of the spinal ERK in morphine dependence and naloxone-precipitated withdrawal response. "
08/01/2002 - "Acute and chronic morphine dependence and naloxone-precipitated withdrawal models were employed in the present study. "
11/01/1995 - "In the present study, we have utilized two differing experimental protocols for the induction of morphine dependence in rats that would represent the extremes of normal laboratory handling procedures and have then assessed withdrawal behaviors following naloxone challenge. "
01/01/2012 - "These results suggest that the selective antagonism of D(3) receptors attenuates the CPA produced by a model of naloxone-induced withdrawal from acute morphine dependence."
11/01/2011 - "Naloxone withdrawal (2 mg kg⁻¹) was performed to assess morphine dependence. "

10/01/1993 - "Is morphine dependence mediated exclusively by the Mu receptor?"
01/01/1993 - "Relative involvement of supraspinal and spinal mu opioid receptors in morphine dependence in mice."
11/01/1987 - "Modulation of brain alpha 2-adrenoceptor and mu-opioid receptor densities during morphine dependence and spontaneous withdrawal in rats."
01/01/1993 - "These results suggest that both supraspinal and spinal mu opioid receptors are involved in the development of morphine dependence and that supraspinal mu receptors play a more important role than spinal mu receptors in withdrawal jumping which may reflect an excitation of the central nervous system whereas supraspinal and spinal mu receptors have similar importance in withdrawal diarrhea which may reflect an abnormal function of the autonomic nervous system."
08/15/2009 - "Synthesis and characterizations of novel quinoline derivatives having mixed ligand activities at the kappa and mu receptors: Potential therapeutic efficacy against morphine dependence."

04/01/2009 - "We examined whether methadone, an opioid often used to treat morphine dependence, also exhibited 5-HT(3) receptor antagonist properties. "
02/01/2009 - "Social service agency inquiries found that the child's grandfather had been prescribed methadone for acquired morphine addiction. "
06/18/1999 - "The functional desensitization of opioid receptors by methadone may explain why methadone is effective in the treatment of morphine dependence."
01/01/2015 - "Although methadone is widely used in maintenance therapy for heroin/morphine addiction, the long-term effects of prenatal exposure to methadone and preventative therapy remain unclear. "
02/02/2012 - "In the present study, we performed proteomes in the NAc of rhesus monkeys of morphine dependence and withdrawal intervention with clonidine or methadone. "

07/25/1997 - "Sears, Alterations in adenosine A receptors in morphine dependence, Brain Res., 657 (1994) 347-350], was used in this current study. "
12/27/1995 - "In intact rats the induction of morphine dependence reduced the potency of these antagonists at inhibiting adenosine-induced decreases in blood pressure. "
09/01/2008 - "Our investigations focused on adenosine A2A agonists as possible vehicles for pharmacotherapy for morphine addiction."
05/01/2009 - "Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence. "
01/01/2000 - "Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence. "

01/01/2014 - "The case reported here is that of a 46-year-old woman with a history of cocaine and morphine abuse who was found dead inside her bathroom. "
01/01/2002 - "On the other hand, D2L is not essential for the rewarding aspects of cocaine and for the development of morphine dependence. "
11/01/2010 - "Our previous research has shown that 1MeTIQ prevents morphine addiction and abates the expression of the reinstatement of cocaine self-administration. "
01/01/1991 - "As malnutrition has been associated with drug use, a low protein diet has been evaluated for its contribution to the impairment of the immune system during cocaine/morphine addiction. "
11/01/2003 - "He used cocaine to treat depression, asthma, cachexia, and for overcoming morphine addiction. "

05/01/2009 - "Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence. "
01/01/2000 - "Dipyridamole, a blocker of adenosine reuptake, induced a significant reduction of morphine dependence. "

02/01/2014 - "These results, along with those reported previously, suggested that morphine dependence may be associated with regionally specific changes in κ-opioid receptor expression in mesocorticolimbic system."
10/01/2011 - "Furthermore, the possible contribution of constitutive opioid receptor activity to precipitated withdrawal was evaluated using increasing levels of morphine dependence. "
10/01/2008 - "In conclusion, it seems that morphine dependence protects the kidney against I/R injury via opioid receptor-dependent pathways. "
02/01/2000 - "The up-regulation of AC/cAMP-PKA signal system in some brain regions occurred in the state of morphine dependence and the effect was mediated via specific activation of opiate receptors. "
11/01/1995 - "[Opioid receptors altered binding nature in guinea-pig brain following the development of morphine dependence]."

08/01/2001 - "Accordingly, we found that ethanol decreased morphine dependence and locomotor sensitization. "
05/01/2011 - "AC5 has been shown to be an essential mediator of morphine addiction and dopamine receptor function; however, it remains unknown whether or not AC5 plays a role in ethanol preference and sensitivity in animals. "
11/01/1997 - "These results demonstrate that ethanol, like dizocilpine, attenuates the development of morphine dependence. "
11/01/1997 - "Ethanol attenuation of morphine dependence: comparison to dizocilpine."
07/01/1982 - "The purpose of the present paper is to investigate the effect of combined treatment of morphine and ethanol on preference for morphine or ethanol and morphine dependence formation. "

09/15/2010 - "Both naloxone and L-NAME significantly abolished the protective effects of morphine dependence on functional and histological factors. "
03/01/2002 - "L-NAME (5 and 10 mg/kg) did not affect the development of morphine dependence, but significantly potentiated the effects of both subeffective (0.01 mg/kg) and effective (0.03 mg/kg) doses of clonidine. "
03/14/2003 - "L-NAME (20 mg/kg, i.p.) significantly (p < 0.05) enhanced the pain threshold, potentiated morphine-induced analgesia and attenuated the expression phase of morphine dependence which has been characterized by withdrawal signs and body weight loss, but did not modify the induction phase of morphine tolerance and dependence. "
03/01/2002 - "The effects of simultaneous administration of alpha(2) -adrenergic agents with L-NAME or L-arginine on the development and expression of morphine dependence in mice."
02/01/1994 - "L-NAME and NO2Arg also attenuated some signs of morphine dependence, as assessed by naloxone (2 mg/kg)-precipitated withdrawal. "

05/16/2012 - "Our study provides a comprehensive understanding of the metabolic alteration associated with morphine addiction and withdrawal therapy, which may help to develop new pharmacotherapies."
02/02/2012 - "Our study provides a comprehensive understanding of the neuropathophysiology associated with morphine addiction and withdrawal therapy in primate, which is helpful for the development of opiate withdrawal pharmacotherapies."
06/01/1971 - "[Pharmacotherapy of morphine addiction]."
09/01/2008 - "Our investigations focused on adenosine A2A agonists as possible vehicles for pharmacotherapy for morphine addiction."
03/01/2012 - "We can suggest that calcium channel blockers have potential for alleviating nicotine and morphine addiction by selectively decreasing the incentive motivational properties of both drugs, and may be beneficial as smoking cessation or opioid dependence pharmacotherapies."

11/01/2010 - "Our previous research has shown that 1MeTIQ prevents morphine addiction and abates the expression of the reinstatement of cocaine self-administration. "
01/01/1977 - "After morphine self-administration was eliminated, responding to escape from nalorphine was maintained in the postdependent monkeys, showing no difference from escape responding during morphine dependence. "

11/06/1998 - "Acute morphine dependence in mice selectively-bred for high and low analgesia."
02/01/2012 - "The results suggest that the dopamine system of the Pfn may become a therapeutic target for analgesia and the treatment of morphine dependence."
11/11/2010 - "The data suggest that partial α(2C)-activation is compatible with effective enhancement of morphine analgesia and reduction both of morphine tolerance acquisition and morphine dependence acquisition and expression. "
01/01/1990 - ""Paradoxical" analgesia and aggravated morphine dependence induced by opioid antagonists."
10/26/1984 - "These results raise the possibility that different receptor mechanisms mediate morphine analgesia and many of the withdrawal signs associated with morphine dependence."

01/01/1993 - "Morphine dependence was induced by multiple injections of the drug on an incremental staircase dosage regimen for 6 days. "
12/01/2000 - "The results showed that morphine-dependence increased seizure severity only at 1-4th PTZ injections in the kindling model. "
01/01/2014 - "The morphine dependence model was obtained through injections of morphine at increasing doses for 8 days. "
02/01/2012 - "In the present study, the tree shrews (Tupaia belangeri chinensis) developed morphine tolerance and chronic morphine dependence by morphine injections with increasing doses (5, 10, 15, 20 mg/kg body weight for 7 days). "
01/01/2002 - "The genetic relationship between acute and chronic morphine dependence was thus presently studied by comparing mice of 11 inbred strains (129P3, A, AKR, BALB/c, C3H/He, C57BL/6, CBA, DBA/2, LP, SJL, and SWR) for naloxone-precipitated withdrawal jumping responses using three subcutaneous morphine administration paradigms: acute (single injection) or chronic (three daily morphine injections for 4 days) injection, or chronic infusion (7 days via implanted osmotic minipumps). "

01/10/2011 - "In the present study, mice were intraperitoneally injected with 2mg/kg polyinosinic-polycytidylic acid (Poly I:C, a viral mimetic) for 3 days to induce an immune challenge, followed by subcutaneous injection of morphine 3 times per day for 3 days to induce morphine dependence. "
05/15/2001 - "Morphine dependence was induced in male Wistar rats by two daily subcutaneous injections of morphine at increasing doses, and the withdrawal syndrome was precipitated acutely by intraperitoneal administration of naloxone. "
01/01/2000 - "Experiments on mice showed that the GABA-positive preparations (THIP, baclofen, fenibut, valproate sodium) intraperitoneally injected in the course of the morphine addiction development (double daily subcutaneous injections at a dose increasing from 10 to 100 mg/kg over a period of 8 days) and, to a greater extent, upon cessation of the morphine injections, partly reduce manifestations of the naloxone-enhanced (0.1 mg/kg, s.c.) daily abstinence, as evaluated by the hopping activity and pair interaction tests."