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Morphine (MS Contin)

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Also Known As:

MS Contin; Morphia; Duramorph; Morphine Sulfate; Morphine Chloride; Morphine Sulfate (2:1), Anhydrous; Morphine Sulfate (2:1), Pentahydrate; Oramorph SR; SDZ 202-250; SDZ202-250; Chloride, Morphine; Contin, MS; SDZ 202 250; SDZ 202250; SDZ202 250; SDZ202250; Sulfate, Morphine; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-

Networked: 12922 relevant articles (1183 outcomes, 2021 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Suzuki, Tsutomu: 33 articles (04/2015 - 09/2002)
2.	Dehpour, Ahmad Reza: 30 articles (12/2015 - 01/2002)
3.	Narita, Minoru: 27 articles (01/2014 - 09/2002)
4.	Zarrindast, Mohammad-Reza: 23 articles (06/2015 - 05/2002)
5.	Klepstad, Pål: 21 articles (12/2015 - 08/2002)
6.	Mercadante, Sebastiano: 21 articles (12/2015 - 05/2002)
7.	Dahan, Albert: 21 articles (11/2015 - 10/2003)
8.	Bruera, Eduardo: 21 articles (10/2015 - 09/2003)
9.	Wong, Chih-Shung: 21 articles (05/2015 - 06/2002)
10.	Kaasa, Stein: 21 articles (01/2015 - 08/2002)

Related Diseases

1.	Pain (Aches) 12/01/2007 - "For BTP, a mean dose of 28 mg of effervescent morphine (range 10-80 mg) resulted in a highly significant reduction of pain score (mean 7.8 to mean 3.2; P < 0.001). " 01/01/1997 - "In clinical practice, recent advances have been based upon an improved understanding of 'old' substances such as morphine and, at the same time, research continues in the hope of finding the 'ideal' analgesic-effective in most situations but without adverse effects: this appears to be a somewhat utopian arm at present, considering the number of different causes of pain. " 02/01/1985 - "One to two milligrams of intrathecal morphine dramatically relieved their spasticity and pain. " 05/01/2012 - "As pain in the intensive care unit (ICU) is still common despite important progress in pain management, we studied the efficacy of an intravenous bolus of morphine 2.5 vs 7.5 mg for procedural pain relief in patients after cardiothoracic surgery in the ICU. " 04/01/2012 - "The efficacy of consecutive NCPB technique with regard to pain relief was observed by a marked decrease in the visual analog score and in opioid consumption, with preprocedural mean values dropping from (8.7±1.0) and (155±56)mg/day of morphine to (1.8±1.1) and (0)mg/day at the first postprocedural visit, respectively. "
2.	Postoperative Pain 06/01/1990 - "Epidural morphine is effective in the treatment of postoperative pain, but the incidence of associated side effects is high. " 04/01/2011 - "Postoperative pain, morphine use, disease-free and overall survival, and surgical and hospital costs were measured postoperatively and compared between the two groups. " 05/01/2013 - "The intrathecal morphine is effective in postoperative pain control. " 09/01/2010 - "It has been shown to be effective in reducing morphine consumption and improving postoperative pain relief in several clinical settings. " 01/01/2005 - "In contrast, intra-articular morphine does appear to be effective for decreasing postoperative pain."
3.	Neoplasms (Cancer) 01/01/1992 - "Pharmacokinetics and efficacy of rectal versus oral sustained-release morphine in cancer patients." 07/01/1989 - "The use of controlled-release morphine administered at regular 12-hour intervals offers an additional method of providing prolonged comfort with the associated overall improvement in quality of life of the cancer patient." 01/01/2001 - "Many clinical data concerning oral morphine show that it is safe and effective even in the patients with advanced cancer and poor performance status. " 01/01/2000 - "This study showed a limited efficacy of a palliative cancer care workshop on the morphine-prescription figures of the general practitioners in daily practice. " 01/01/2015 - "This study aimed to determine what predicts serum concentrations of morphine in cancer patients receiving continuously intravenous morphine, the relationships between serum concentration of morphine/its metabolites and urinary concentrations, and the relation between morphine concentrations and with clinical outcomes. "
4.	Pruritus (Itching) 03/01/2015 - "In this study, treatment with a peripherally acting μ-opioid antagonist was generally ineffective against intrathecal morphine-induced pruritus, but a small clinical effect cannot be excluded. " 03/01/2015 - "The aim of this study was to determine if a peripherally acting, μ-opioid antagonist would reduce morphine-induced pruritus. " 10/01/2002 - "Although the mediators and exact mechanisms eliciting and sustaining pruritus are not completely known, AE patients in clinical trials have been shown to benefit under treatment with morphine antagonists. " 08/01/1985 - "One of the frequently reported side effects following epidural morphine administration in clinical trials is a generalized pruritus of several hours duration. " 05/01/1984 - "Two patients in group I and one patient in group II had generalized pruritus, and in one study patient bradypnea developed in association with the epidural administration of morphine. "
5.	Hyperalgesia 12/31/1993 - "Morphine pre-treatment was less effective in preventing development of hyperalgesia; however, whilst the ipsilateral (146 +/- 18 g) paw withdrawal threshold tended to be lower than the contralateral (183 +/- 8 g), this was not significant.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/01/2004 - "A higher dose of morphine was required to produce mechanical allodynia in postnatal day 21 versus 7 rats but this increase was independent of the analgesic efficacy of morphine at these two ages. " 12/01/2006 - "However, compared with the control group, 1 mg/kg morphine was equally effective in reducing mechanical hyperalgesia among groups of animals gonadectomized as adults, but less effective in males gonadectomized neonatally. " 01/17/2003 - "Intrathecal morphine was also effective in alleviating the tactile allodynia induced by LPS. " 10/01/1989 - "On the other hand, when the dorsolateral funiculus was lesioned, the hyperalgesia was no longer observed, yet the antagonist remained effective against morphine. "

Related Drugs and Biologics

1.	Fentanyl (Sublimaze)
2.	Bupivacaine (Bupivacaine Hydrochloride)
3.	Opioid Analgesics (Opioids)
4.	Ketamine
5.	Methadone (Dolophine)
6.	Ketorolac
7.	Acetaminophen (Paracetamol)
8.	Oxycodone (Oxycontin)
9.	Naloxone (Narcan)
10.	Tramadol

Related Therapies and Procedures

1.	Analgesia
2.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
3.	Cesarean Section (Caesarean Section)
4.	Thoracotomy
5.	Epidural Analgesia