Morphinans

Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.

Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Kim, Hyoung-Chun: 2 articles (10/2010 - 03/2003)
2.	Shin, Eun-Joo: 2 articles (10/2010 - 03/2003)
3.	Galen, Karen P: 1 article (04/2013)
4.	Mehal, Wajahat: 1 article (04/2013)
5.	Malik, Ahsan: 1 article (04/2013)
6.	Hoque, Rafaz: 1 article (04/2013)
7.	Trawick, Bobby N: 1 article (04/2013)
8.	McClurg, Joseph P: 1 article (04/2013)
9.	Farooq, Ahmad: 1 article (04/2013)
10.	Berberich, David W: 1 article (04/2013)

Related Diseases

1.	Seizures (Seizure) 03/07/2003 - "In order to extend our understanding of the pharmacological intervention of these morphinans, we assessed their behavioral effects, and then examined whether they exert protective effects on maximal electroshock convulsions (MES) in mice. "
2.	Pain (Aches) 03/01/2013 - "Morphinans have a storied history in medicinal chemistry as pain management drugs but have received attention as modulators of cholinergic signaling for the treatment of Alzheimer's Disease (AD). " 06/02/1994 - "Resolved axial (beta) and equatorial (alpha) forms of S-methyl (beta-sulforphanol, alpha-sulforphanol) and S-allyl (beta-sulfallorphan, alpha-sulfallorphan) morphinans were tested for their ability to depress the electrically evoked contractions of the guinea pig ileum and of the mouse vas deferens, to compete with the binding of prototype ligands selective for mu-, delta-, and kappa-opioid receptors in membrane preparations of rat brain and guinea pig cerebellum and to produce analgesia in a rat thermal pain assay. "
3.	Substance-Related Disorders (Drug Abuse) 03/24/2011 - "These novel N'-monosubstituted aminothiazole-derived morphinans may be valuable for the development of drug abuse medications."
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 10/01/2010 - "The neuroprotective effects and the therapeutic potential for the treatment of excitotoxic and inflammatory neurodegenerative diseases, and underlying mechanism of morphinans are discussed." 10/01/2010 - "This review will demonstrate novel neuroprotective effects of several morphinans such as, dextromethorphan, its analogs and naloxone on the models of multiple neurodegenerative disease by modulating glial activation associated with the production of a host of proinflammatory and neurotoxic factors, although dextromethorphan possesses neuropsychotoxic potentials. "
5.	Neoplasms (Cancer) 07/01/1987 - "Effect of several d-morphinans on ascites tumors in mice."

Related Drugs and Biologics

1.	Naloxone (Narcan)
2.	kappa Opioid Receptors (kappa Opioid Receptor)
3.	mu Opioid Receptors (mu Opioid Receptor)
4.	Guanosine 5'-O-(3-Thiotriphosphate)
5.	Naltrexone (ReVia)
6.	Ligands
7.	Guanosine
8.	Glucose (Dextrose)
9.	Dextromethorphan (Levomethorphan)
10.	triphosphoric acid (triphosphate)

Related Therapies and Procedures

1.	Analgesia