Morphinans

Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.

Also Known As:

Networked: 33 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Carraz, Maëlle: 2 articles (02/2022 - 12/2006)
2.	Franetich, Jean-François: 2 articles (02/2022 - 12/2006)
3.	Mazier, Dominique: 2 articles (02/2022 - 12/2006)
4.	Zhang, Yan: 2 articles (12/2019 - 01/2019)
5.	Zheng, Yi: 2 articles (12/2019 - 01/2019)
6.	Hong, Jau-Shyong: 2 articles (10/2011 - 10/2010)
7.	Husbands, Stephen M: 2 articles (01/2009 - 02/2005)
8.	Nagase, Hiroshi: 2 articles (09/2008 - 04/2004)
9.	Nakao, Kaoru: 2 articles (09/2008 - 04/2004)
10.	Traynor, John R: 2 articles (03/2006 - 02/2005)

Related Diseases

1.	Pain (Aches) 06/14/2023 - "Peripheralization Strategies Applied to Morphinans and Implications for Improved Treatment of Pain." 06/02/1994 - "In the rat thermal pain assay, beta-sulforphanol (intracisternally, i.c.) was more potent than alpha-sulforphanol in producing analgesia while the other morphinan derivatives were inactive.(ABSTRACT TRUNCATED AT 250 WORDS)" 07/17/2015 - "Morphinan alkaloids from the opium poppy are used for pain relief. " 04/01/2004 - "Suppression of acute herpetic pain-related responses by the kappa-opioid receptor agonist (-)-17-cyclopropylmethyl-3,14beta-dihydroxy-4,5alpha-epoxy-beta-[n-methyl-3-trans-3-(3-furyl) acrylamido] morphinan hydrochloride (TRK-820) in mice." 03/01/2007 - "Oxymorphone is a potent morphinan-type mu-opioid analgesic used for treatment of moderate-to-severe pain. "
2.	Substance-Related Disorders (Drug Abuse) 03/24/2011 - "These novel N'-monosubstituted aminothiazole-derived morphinans may be valuable for the development of drug abuse medications." 02/21/2005 - "In the search for opioid agonists with delayed antagonist actions as potential treatments for substance abuse, the bridged morphinan BU74 (17-cyclopropylmethyl-3-hydroxy-[5beta,7beta,3',5']-pyrrolidino-2'[S]-phenyl-7alpha-methyl-6,14-endoetheno morphinan) (3f) was synthesized. " 01/01/2021 - "For example, the methods have been applied to efficient asymmetric syntheses of morphinan drugs, including the opioid antagonist (-)-naltrexone, which is extensively used for the treatment of drug abuse."
3.	Cough 10/01/2011 - "Dextromethorphan (DM) is a dextrorotary morphinan and a widely used component of cough medicine. " 11/01/2015 - "Dextromethorphan, an antitussive (cough suppressant) drug of the morphinan class with sedative and dissociative properties found in cough syrup and other over-the-counter products, is also a substance of abuse, seen primarily in young adults all over the world. " 09/01/2008 - "We have previously reported on antitussive effect of (5R,9R,13S,14S)-17-cyclopropylmethyl-6,7-didehydro-4,5-epoxy-5',6'-dihydro-3-methoxy-4'H-pyrrolo[3,2,1-ij]quinolino[2',1':6,7]morphinan-14-ol(1b) methanesulfonate (TRK-850), a selective delta opioid receptor antagonist which markedly reduced the number of coughs in a rat cough model. "
4.	Cocaine-Related Disorders (Cocaine Addiction) 10/22/2001 - "Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan." 01/13/2000 - "Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence." 01/13/2000 - "This report concerns the synthesis and preliminary pharmacological evaluation of a novel series of kappa agonists related to the morphinan (-)-cyclorphan (3a) and the benzomorphan (-)-cyclazocine (2) as potential agents for the pharmacotherapy of cocaine abuse. "
5.	Opioid-Related Disorders (Opiate Addiction) 12/15/2019 - "Pharmacological characterization of 17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-[(3'-fluoro-4'-pyridyl)acetamido]morphinan (NFP) as a dual selective MOR/KOR ligand with potential applications in treating opioid use disorder." 01/01/2011 - "The antagonist morphinans, naloxone and naltrexone are used to treat opioid overdose, opioid dependence, and alcoholism. "

Related Drugs and Biologics

1.	Dextromethorphan (Racemethorphan)
2.	Alkaloids
3.	Naloxone (Narcan)
4.	kappa Opioid Receptors (kappa Opioid Receptor)
5.	delta Opioid Receptors (delta Opioid Receptor)
6.	N-Methylaspartate (NMDA)
7.	Opioid Receptors (Opioid Receptor)
8.	Narcotic Antagonists (Opioid Antagonists)
9.	Naltrexone (ReVia)
10.	Ligands

Related Therapies and Procedures

1.	Analgesia
2.	Pain Management
3.	Drug Therapy (Chemotherapy)