Monoclonal Gammopathy of Undetermined Significance

Conditions characterized by the presence of M protein (Monoclonal protein) in serum or urine without clinical manifestations of plasma cell dyscrasia.
Also Known As:
Monoclonal Gammapathies, Benign; Benign Monoclonal Gammapathies; Benign Monoclonal Gammapathy; Benign Monoclonal Gammopathy; Gammapathies, Benign Monoclonal; Gammapathy, Benign Monoclonal; Gammopathies, Benign Monoclonal; Gammopathy, Benign Monoclonal; Monoclonal Gammapathy, Benign; Monoclonal Gammopathy, Benign; Benign Monoclonal Gammopathies; Monoclonal Gammapathy of Undetermined Significance; Monoclonal Gammopathies, Benign
Networked: 563 relevant articles (18 outcomes, 45 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Multiple Myeloma
2. Waldenstrom Macroglobulinemia (Macroglobulinemia)
3. Polyneuropathies (Polyneuropathy)
4. Aneuploidy (Aneuploid)
5. Nephrotic Syndrome (Syndrome, Nephrotic)


1. Rajkumar, S Vincent: 20 articles (11/2013 - 07/2002)
2. Dispenzieri, Angela: 17 articles (04/2013 - 07/2002)
3. Kyle, Robert A: 17 articles (04/2013 - 07/2002)
4. Landgren, Ola: 11 articles (11/2015 - 12/2006)
5. Terpos, Evangelos: 8 articles (06/2014 - 09/2004)
6. Larson, Dirk R: 8 articles (04/2013 - 11/2003)
7. Fonseca, Rafael: 7 articles (04/2013 - 07/2002)
8. Melton, L Joseph: 7 articles (04/2013 - 11/2003)
9. Kumar, Shaji: 6 articles (04/2013 - 08/2004)
10. Plevak, Matthew F: 6 articles (12/2006 - 07/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Monoclonal Gammopathy of Undetermined Significance:
1. Immunoglobulin G (IgG)IBA
2. ThymidineIBA
3. Immunoglobulin M (IgM)IBA
4. Interleukin-6 (Interleukin 6)IBA
02/01/2006 - "Patients with active myeloma induced quantitatively higher levels of stromal cell IL-6 production when compared with those with monoclonal gammopathy of undetermined significance (MGUS). "
01/01/1994 - "Applying a bioassay and a modified ELISA, we measured serum IL-6 values in 64 patients with overt MM, seven patients with smouldering myeloma (SMM), 57 patients with monoclonal gammopathy of undetermined significance (MGUS) and 40 healthy volunteers as controls. "
03/01/1992 - "The serum IL-6 levels in 200 normal individuals were less than 3 pg/ml. Serum IL-6 concentration in patients with malignant and benign monoclonal gammopathy (BMG) was determined by an ELISA. "
08/01/2001 - "Intracellular cytokine production by peripheral blood mononuclear cells (PBMC) was analysed in 51 patients with multiple myeloma (MM), 22 with monoclonal gammopathy of undetermined significance (MGUS) and 20 healthy subjects, as a parameter of immunological dysfunction in MM. An increased proportion of T cells and HLA-DR+ cells producing IL-6 was observed in MM patients with active disease (at diagnosis and relapsing) compared with patients in remission and with MGUS, whereas no difference of IFN-gamma+, IL-2+ PBMC between patients and controls was evident. "
01/15/2001 - "In this study, flow cytometry was used to evaluate interleukin-6 (IL-6) production by bone marrow mononuclear cells from 47 patients with multiple myeloma (MM) in different clinical stages and 15 patients with monoclonal gammopathy of undetermined significance. "
5. Immunoglobulins (Immunoglobulin)IBA
6. Monoclonal AntibodiesIBA
7. Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
08/01/2006 - "Previous studies of quantifying vascular endothelial growth factor (VEGF) and VEGF receptors (VEGFR) in plasma cells from patients at different stages of MM found no significant difference in expression between overt MM and earlier pre-malignant stages of the disease namely, monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). "
08/15/2004 - "We compared the angiogenic potential of bone marrow plasma and the expression of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and their receptors on plasma cells from patients with monoclonal gammopathy of undetermined significance (MGUS), smoldering multiple myeloma (SMM), and newly diagnosed multiple myeloma (NMM). "
09/01/2015 - "In this study, we examined the association between bone marrow angiogenesis estimated as micro-vessel density (MVD) and gene expression of SDC1, HGF, VEGF and IL6 in whole bone marrow biopsies from healthy volunteers (n = 10), patients with monoclonal gammopathy of undetermined significance (MGUS) (n = 35) and MM (n = 65). "
06/01/2007 - "Serum levels of vascular endothelial growth factor (VEGF), VEGF-A, angiogenin, angiopoietin (Ang)-1 and -2, and basic fibroblast growth factor (bFGF) were evaluated in 56 WM patients at different disease phases (24 untreated, 20 relapsed/refractory and 12 patients at remission) and 11 patients with immunoglobulin M type monoclonal gammopathy of undetermined significance (IgM-MGUS). "
01/01/2010 - "Statistically non-significant differences between multiple myeloma and monoclonal gammopathy of undetermined significance were within the serum levels of IGF-1, osteocalcin, bALP, PINP, OPG, MIP-1 beta, IL-17, parathormon and VEGF. "
8. Proteins (Proteins, Gene)IBA
9. AntibodiesIBA
10. DNA (Deoxyribonucleic Acid)IBA

Therapies and Procedures

1. Stem Cell Transplantation
2. Tooth Extraction (Tooth Extractions)
3. Drug Therapy (Chemotherapy)
01/01/2015 - "This article includes three points: 1) the progression rate of monoclonal gammopathy of undetermined significance (MGUS) to MM, 2) the effect of radiation to prevalence of MM, and 3) secondary malignancy after chemotherapy used to treat MM. The risk of progression from MGUS to MM is 1% per year. "
10/01/2004 - "The aim of this study was to assess the effect of systemic chemotherapy on the monoclonal protein levels of patients with solid tumors who also have a monoclonal gammopathy of undetermined significance (MGUS). "
10/01/2004 - "Monoclonal gammopathy of undetermined significance (MGUS) in patients with solid tumors: effects of chemotherapy on the monoclonal protein."
01/01/2006 - "In presented study was evaluated serum sCD138 level in 14 patients with monoclonal gammopathy of undetermined significance (MGUS) and in 17 patients with multiple myeloma (MM), all MM patients were treated by high-dose chemotherapy regimen with subsequent autologous transplantation of peripheral blood stem cells. "
01/01/1988 - "The second group (n = 50; 132 +/- 54 plasma cells per square millimeter bone marrow) with plasmacytic differentiation of infiltrates, had to be further divided into one component with evidence for initial or residual MM following chemotherapy (n = 27), another with obviously monoclonal gammopathy of undetermined significance--benign monoclonal gammopathy (BMG, n = 6), and a final set of cases with a reactive plasmacytosis mostly associated with an inflammatory condition (n = 17). "
4. Immunotherapy
5. Transplants (Transplant)