Monobactams (Monobactam Antibiotics)

Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.

Also Known As:

Monobactam Antibiotics; Monocyclic beta Lactam; Monocyclic beta Lactams; beta Lactams, Monocyclic; beta-Lactam, Monocyclic; Antibiotics, Monobactam; Monobactam; Monocyclic beta-Lactam; Monocyclic beta-Lactams; beta-Lactams, Monocyclic

Networked: 118 relevant articles (11 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Growcott, E J: 3 articles (01/2019 - 01/2019)
2.	Caruso, Cristiano: 2 articles (01/2021 - 11/2010)
3.	Gaeta, Francesco: 2 articles (01/2021 - 11/2010)
4.	Romano, Antonino: 2 articles (01/2021 - 11/2010)
5.	Valluzzi, Rocco Luigi: 2 articles (01/2021 - 11/2010)
6.	Macy, Eric: 2 articles (01/2020 - 11/2014)
7.	Ansaldi, D A: 2 articles (01/2019 - 01/2019)
8.	Cariaga, T A: 2 articles (01/2019 - 01/2019)
9.	Gamboa, L: 2 articles (01/2019 - 01/2019)
10.	Gold, J: 2 articles (01/2019 - 01/2019)

Related Diseases

1.	Urinary Tract Infections (Urinary Tract Infection) 05/01/1984 - "Azthreonam, the first monobactam, was given to 40 patients with urinary tract infection. " 06/01/1990 - "Carumonam (CRMN), the first monobactam antibiotic in Japan, has excellent activity against gram-negative bacteria and is useful in the treatment of urinary tract infections. " 01/01/1989 - "A multicenter trial involving several urologic units in Italy provided pooled data on 1,427 patients with urinary tract infections to evaluate the efficacy and safety of aztreonam, a new monobactam antibiotic. " 11/01/1988 - "Aztreonam: critical evaluation of the first monobactam antibiotic in treatment of urinary tract infections." 07/01/1983 - "In a single blind study we compared the efficacy of aztreonam (Az), a novel monocyclic beta-lactam antibiotic, to that of cefamandole (Cef) in the treatment of serious urinary tract infections (UTIs). "
2.	Infections 06/01/2020 - "Monobactam antibiotics are known to be effective against such infections. " 01/01/2019 - "Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection." 01/01/2019 - "Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection." 10/01/2018 - "The monobactam scaffold is attractive for the development of new agents to treat infections caused by drug-resistant Gram-negative bacteria because it is stable to metallo-β-lactamases (MBLs). " 01/01/2018 - "aureus infection", and "Monobactam biosynthesis" were significantly enriched. "
3.	Gram-Negative Bacterial Infections 06/01/2020 - "The models developed and verified in this study provide a powerful design strategy for novel monobactams that are effective against MDR gram-negative bacterial infections." 08/01/1986 - "This study provides evidence that monobactams at sub-MICs may work in partnership with host defenses against Gram-negative bacterial infections."
4.	Fever (Fevers) 05/01/1989 - "The incidence of perineal wound and abdominal infections, of fever, of need for postoperative antibiotics and the length of postoperative stay were lower in the monobactam group, even if none of these differences were statistically significant. " 05/01/1989 - "The incidence of perineal wound and abdominal infections, of fever, of need for postoperative antibiotics and the length of postoperative stay were lower in the monobactam group, even if none of these differences were statistically significant. " 01/01/1998 - "We evaluated the efficacy of a combined antibiotic regimen of monobactam (aztreonam) and antipseudomonal penicillin (piperacillin) in treating neutropenic fever episodes in gynecologic-oncology patients receiving cisplatin-based chemotherapy. "
5.	Healthcare-Associated Pneumonia 06/01/1988 - "Aztreonam, the first clinically available monobactam antibiotic, achieves high serum levels and adequate levels in bronchial secretions and lung parenchyma for efficacy against most Gram-negative pathogens implicated in nosocomial pneumonias. " 01/01/1989 - "Combination therapy with an aminoglycoside and a beta-lactam has long been the cornerstone of therapy, and clinical success has been correlated with peak serum bactericidal levels of 1:8 in non-granulocytopenic patients and peak gentamicin and tobramycin levels greater than 8 micrograms/ml. The introduction of new broad-spectrum antibiotics, such as monobactams, third-generation cephalosporins and imipenem, has introduced the possibility of monotherapy for the treatment of nosocomial pneumonia. "

Related Drugs and Biologics

1.	Aztreonam
2.	Anti-Bacterial Agents (Antibiotics)
3.	Gentamicins (Gentamicin)
4.	Cefamandole
5.	Penicillins (Penicillin)
6.	Clindamycin (Cleocin)
7.	carumonam
8.	Piperacillin
9.	Creatinine
10.	Cisplatin (Platino)

Related Therapies and Procedures

1.	Peritoneal Dialysis
2.	Renal Dialysis (Hemodialysis)
3.	Drug Therapy (Chemotherapy)
4.	Therapeutics
5.	Injections