Monensin (Coban)

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.

Also Known As:

Networked: 519 relevant articles (44 outcomes, 48 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Duffield, T F: 7 articles (12/2012 - 05/2000)
2.	Bagg, R: 5 articles (04/2007 - 02/2002)
3.	Dick, P: 5 articles (04/2007 - 02/2002)
4.	McBride, B W: 4 articles (04/2007 - 12/2002)
5.	Vessie, G: 4 articles (04/2007 - 12/2002)
6.	Park, Woo Hyun: 4 articles (07/2003 - 11/2002)
7.	Erickson, G E: 3 articles (05/2013 - 11/2003)
8.	Klopfenstein, T J: 3 articles (05/2013 - 11/2003)
9.	Mutsvangwa, T: 3 articles (06/2004 - 12/2002)
10.	Kim, Eun Shil: 3 articles (07/2003 - 11/2002)

Related Diseases

1.	Coccidiosis 01/01/2012 - "The aim of the present study was to investigate the efficacy of monensin sodium grain size on controlling coccidiosis in broiler chickens. " 09/01/2010 - "In this review, we discuss the discovery, mode of action, and efficacy of monensin, together with matters of importance to the poultry industry such as commercial use, drug resistance, toxicity, pharmacology and residues, host immunity to coccidiosis, and effects in other avian species." 11/01/1986 - "Young Holstein-Friesian bull calves were used in a controlled experiment to evaluate the efficacy of monensin against coccidiosis. " 09/01/1978 - "Efficacy of monensin against coccidiosis in lambs." 08/01/1976 - "Efficacy of different feeding levels of monensin in the control of coccidiosis in broilers."
2.	Body Weight (Weight, Body) 09/01/1999 - "Treatment with SBC significantly improved coccidial lesion score, 45-d body weight, and feed efficiency compared with monensin alone. " 09/01/2011 - "The higher body weight of cattle treated with monensin may have been due to improved energy utilisation of the pasture, indicated by increased propionate proportions in the rumen, rather than prevention of SARA." 06/01/2014 - "Monensin treatment improved the organ weight/body weight ratios. " 03/01/1988 - "Animal fat fed at 6.8% of the diet consistently improved body weight, daily feed intake, and feed conversion regardless of monensin level. " 10/01/1986 - "Monensin at .66 and .99 mg/kg body weight daily reduced the severity of legume bloat by 41 and 73%, respectively. "
3.	Infection 01/01/1999 - "In floor pens in which poults were exposed to infection, use of 59.5, 79.4, and 99.2 ppm monensin resulted in reduced mortality and improved feed conversion at 3 wk of age compared with birds that had received no medication. " 08/01/1976 - "Conversely, the relationship of plasma pigmentation and total lesion scores to monensin feed levels indicated that increasing the dosage of monensin from 100 to 121 ppm improved the performance of the broilers on the basis of these 2 infection indicators." 10/01/1986 - "Trial 1 had a 2 X 2 X 2 factorial design wherein diets containing 16 or 24% CP and 0 or 121 mg/kg monensin were fed in the presence and absence of Eimeria acervulina infection. " 06/01/1986 - "In Experiment 2, identical levels of monensin were added to diets containing either 2600 or 3200 kcal metabolizable energy/kg. Both studies were conducted in the presence and the absence of infections produced by Eimeria acervulina, E. " 11/01/2011 - "Monensin, may aid in the prevention of infection in calves and to lower MAP fecal shedding in infected adult cattle."
4.	Weight Gain 12/01/1983 - "Lambs receiving monensin tended to produce drier faeces but their weight gain was not significantly greater than that of controls. " 02/01/1988 - "Monensin increased cow weight gains precalving and improved feed efficiency postcalving." 09/01/1980 - "Two trials were conducted to determine the influence of monensin on live weight gain and efficiency of forage utilization of calves grazing Bermudagrass. " 01/01/1999 - "There was no significant difference in the weight gain or feed conversion of poults from 10 to 14 wk of age whether monensin was present in the feed or had been withdrawn. " 04/01/1994 - "Monensin had no effect on the weight gain and feed efficiency of ad libitum birds, but monensin exacerbated the decrease on gain (monensin by regimen, P < .01) and feed efficiency (monensin by regimen, P < .09) induced by feed and water restriction. "
5.	Ketosis 09/01/2015 - "Efficacy of controlled-release capsules containing monensin for the prevention of subclinical ketosis in pasture-fed dairy cows." 11/01/1998 - "Efficacy of monensin for the prevention of subclinical ketosis in lactating dairy cows." 02/01/1989 - "The addition of 30 g monensin/ton of feed decreased the incidence of subclinical ketosis from 6 out of 12 to 1 out of 12. " 01/16/2006 - "The objective of this study was to determine the effect of a monensin controlled-release capsule on the proportion of cows with subclinical ketosis (SK). " 09/01/2015 - "To determine the effectiveness of intra-rumenal controlled release capsules (CRC) containing 32 g of monensin administered pre-calving to reduce the cumulative incidence of subclinical ketosis (SCK) in mainly pasture-fed dairy cows. "

Related Drugs and Biologics

1.	salinomycin
2.	Lasalocid
3.	Amprolium
4.	halofuginone
5.	Liposomes (Liposome)
6.	Ricin
7.	Ionophores
8.	Selenium
9.	Sirolimus (Rapamycin)
10.	Epidermal Growth Factor Receptor (EGF Receptor)

Related Therapies and Procedures

1.	Skin Transplantation (Skin Grafting)
2.	Microspheres (Microsphere)
3.	Compression Bandages
4.	Heterologous Transplantation (Xenotransplantation)
5.	Massage (Reflexology)