Monensin (Coban)

An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.

Also Known As:

Networked: 673 relevant articles (60 outcomes, 81 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Duffield, T F: 8 articles (10/2019 - 05/2000)
2.	Bagg, R: 5 articles (04/2007 - 02/2002)
3.	Dick, P: 5 articles (04/2007 - 02/2002)
4.	Huczyński, Adam: 4 articles (12/2020 - 10/2015)
5.	Hickey, Elizabeth E: 4 articles (09/2020 - 04/2018)
6.	Page, Stephen W: 4 articles (09/2020 - 04/2018)
7.	Trott, Darren J: 4 articles (09/2020 - 04/2018)
8.	Gluhcheva, Yordanka: 4 articles (03/2020 - 01/2014)
9.	Ivanova, Juliana: 4 articles (03/2020 - 01/2014)
10.	McBride, B W: 4 articles (04/2007 - 12/2002)

Related Diseases

1.	Coccidiosis 06/19/2021 - "Hence, monensin supplementation successfully improved growth performance of creep-fed suckling beef calves, when herbage mass was not a limiting factor and coccidiosis infestation occurred." 01/01/2012 - "The aim of the present study was to investigate the efficacy of monensin sodium grain size on controlling coccidiosis in broiler chickens. " 09/01/2010 - "In this review, we discuss the discovery, mode of action, and efficacy of monensin, together with matters of importance to the poultry industry such as commercial use, drug resistance, toxicity, pharmacology and residues, host immunity to coccidiosis, and effects in other avian species." 11/01/1986 - "Young Holstein-Friesian bull calves were used in a controlled experiment to evaluate the efficacy of monensin against coccidiosis. " 10/01/1978 - "Monensin at 60, 80 or 100 ppm provided sufficient early protection against coccidiosis in floor-pens seeded with a mixture of Eimeria adenoeides, E. "
2.	Body Weight (Weight, Body) 09/01/1999 - "Treatment with SBC significantly improved coccidial lesion score, 45-d body weight, and feed efficiency compared with monensin alone. " 05/01/2019 - "This study indicated that monensin supplementation at 0.6 mg/kg body weight in growing heifers improved daily gain and feed efficiency while it reduced enteric methane production which can reduce feedlot time and consequent life time CH4 production." 06/01/2014 - "Monensin treatment improved the organ weight/body weight ratios. " 03/01/1988 - "Animal fat fed at 6.8% of the diet consistently improved body weight, daily feed intake, and feed conversion regardless of monensin level. " 10/01/1986 - "Monensin at .66 and .99 mg/kg body weight daily reduced the severity of legume bloat by 41 and 73%, respectively. "
3.	Infections 06/04/2020 - "gondii infection of hBMECs, monensin was still effective in limiting the growth of T. " 01/01/1999 - "In floor pens in which poults were exposed to infection, use of 59.5, 79.4, and 99.2 ppm monensin resulted in reduced mortality and improved feed conversion at 3 wk of age compared with birds that had received no medication. " 08/01/1976 - "Conversely, the relationship of plasma pigmentation and total lesion scores to monensin feed levels indicated that increasing the dosage of monensin from 100 to 121 ppm improved the performance of the broilers on the basis of these 2 infection indicators." 10/01/2019 - "Monensin-supplemented MAP-infected calves demonstrated evidence for resilience to MAP infection earlier in this study compared with monensin-free MAP-infected calves. " 10/01/1986 - "Trial 1 had a 2 X 2 X 2 factorial design wherein diets containing 16 or 24% CP and 0 or 121 mg/kg monensin were fed in the presence and absence of Eimeria acervulina infection. "
4.	Weight Gain 12/01/1983 - "Lambs receiving monensin tended to produce drier faeces but their weight gain was not significantly greater than that of controls. " 02/01/1988 - "Monensin increased cow weight gains precalving and improved feed efficiency postcalving." 09/01/1980 - "Two trials were conducted to determine the influence of monensin on live weight gain and efficiency of forage utilization of calves grazing Bermudagrass. " 10/10/2023 - "However, monensin promoted greater weight gain in the animals (110 g/animal/day). " 01/01/1999 - "There was no significant difference in the weight gain or feed conversion of poults from 10 to 14 wk of age whether monensin was present in the feed or had been withdrawn. "
5.	Neoplasms (Cancer) 01/01/2020 - "Furthermore, monensin significantly inhibits proliferation of primary murine AML cells but not of normal hematopoietic progenitors, reflecting a high MYB-dependence of leukemic cells and underscoring the efficacy of monensin in MYB-activated malignancies. " 01/01/2020 - "However, monensin is more effective in targeting endothelial cells than tumor cells. " 12/01/2021 - "Xenograft studies verified that monensin effectively inhibited xenograft tumor growth by increasing the SUMOylation of MEK1. " 12/17/2018 - "Furthermore, the in vivo study shows that monensin blunts PDAC xenograft tumor growth by suppressing cell proliferation via targeting EGFR pathway. " 01/01/2018 - "An important finding of our studies is the demonstration of the in vivo treatment efficacy of TRAIL/monensin, thus providing a potential novel therapeutic strategy for overcoming drug-resistant cancer."

Related Drugs and Biologics

1.	salinomycin
2.	Lasalocid
3.	Ionophores
4.	Amprolium
5.	Liposomes (Liposome)
6.	narasin
7.	Nicarbazin
8.	halofuginone
9.	Coccidiostats
10.	Ricin

Related Therapies and Procedures

1.	Therapeutics
2.	Bone Wires
3.	Skin Transplantation (Skin Grafting)
4.	Microspheres (Microsphere)
5.	Compression Bandages