Plicamycin

A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.

Also Known As:

Networked: 214 relevant articles (13 outcomes, 18 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Rohr, Jürgen: 5 articles (05/2013 - 07/2003)
2.	Dasgupta, Dipak: 4 articles (03/2015 - 04/2008)
3.	Gambari, Roberto: 4 articles (01/2015 - 08/2003)
4.	Catapano, Carlo V: 4 articles (01/2012 - 07/2003)
5.	Carbone, Giuseppina M: 4 articles (01/2012 - 07/2003)
6.	Banerjee, Amrita: 3 articles (03/2015 - 01/2014)
7.	Lampronti, Ilaria: 3 articles (01/2015 - 09/2003)
8.	Borgatti, Monica: 3 articles (01/2015 - 08/2003)
9.	Bianchi, Nicoletta: 3 articles (01/2015 - 08/2003)
10.	Morís, Francisco: 3 articles (01/2014 - 01/2012)

Related Diseases

1.	Hypercalcemia (Milk Alkali Syndrome) 02/01/1979 - "Mithramycin is effective in the treatment of hypercalcemia. " 01/01/1992 - "In contrast, mithramycin was effective only in 3 out of 11 patients, and in these patients hypercalcemia recurred rapidly. " 06/04/1988 - "Fatal course despite control of hypercalcemia with mithramycin]." 03/01/1985 - "[A case of malignant hypercalcemia treated with mitramycin]." 11/01/1984 - "The medical records of patients receiving mithramycin for the treatment of hypercalcemia at The Johns Hopkins Oncology Center were reviewed. "
2.	Neoplasms (Cancer) 10/01/1980 - "The data on efficacy of mitramycin, an antitumor antibiotic in treatment of 32 patients with cancer of the testicle are presented. " 12/01/1965 - "Preliminary clinical study of mithramycin (nsc-24559) in primary tumors of the central nervous system." 07/14/2014 - "Targeting Sox2(+) cells with the antineoplastic mithramycin abrogated tumor growth. " 05/01/2013 - "Mithramycin (MTM) is a potent anti-cancer agent that has recently garnered renewed attention. " 06/28/2012 - "Mithramycin is an antitumor compound produced by Streptomyces argillaceus that has been used for the treatment of several types of tumors and hypercalcaemia processes. "
3.	Blast Crisis (Blast Phase) 01/01/1987 - "These results suggest that plicamycin may be effective in suppressing proliferation of blasts and promoting their maturation in the myeloid blast phase of CML, but that plicamycin alone may not be effective enough to sustain duration of response." 01/01/1991 - "Failure of mithramycin to control the myeloid blast phase of chronic granulocytic leukemia: a report on nine patients and review of the literature." 01/01/1987 - "Two cases in myeloid blast phase of chronic myelogenous leukemia (CML) responded to treatment with plicamycin alone. " 07/01/1990 - "In conclusion, combination use of vincristine and mithramycin may be useful in the treatment of the myeloid blast crisis." 09/01/1990 - "In our hands the combination of plicamycin and hydroxyurea was ineffective in patients with CGL in blast crisis. "
4.	Osteitis Deformans (Paget's Disease of Bone) 01/01/1980 - "Mithramycin and long remission of Paget's disease of bone." 10/01/1980 - "Mithramycin treatment of Paget's disease of bone. " 03/01/1979 - "Long term effectiveness of low dose mithramycin for Paget's disease of bone." 11/01/1974 - "Outpatient treatment of Paget's disease of bone with mithramycin." 06/09/1973 - "Mithramycin in Paget's disease of bone."
5.	Bone Resorption 09/30/1993 - "During studies on the mechanism of action of mithramycin it became clear that the compound has a direct inhibitory effect on osteoclastic bone resorption in the in vitro bone slice assay. " 09/30/1993 - "At concentrations of 0.1-100 nM mithramycin directly inhibited osteoclastic bone resorption dose-dependently up to 66 +/- 5% at 100 nM (mean +/- SEM, 3 expts.). " 10/26/1985 - "By day 9, however, about 50% of the mithramycin-treated patients had started to relapse as bone resorption increased again. " 01/01/1981 - "Mithramycin given to the same patients further reduced hypercalcaemia, presumably by inhibiting bone resorption. " 02/01/1979 - "It appears that mithramycin has a preferential effect on bone resorption."

Related Drugs and Biologics

1.	Plicamycin
2.	Diphosphonates
3.	DNA (Deoxyribonucleic Acid)
4.	Hydroxyurea (Hydrea)
5.	Vincristine (Oncovin)
6.	Sp Transcription Factors
7.	Bleomycin (Blenoxane)
8.	Curcumin
9.	celecoxib (Celebrex)
10.	tolfenamic acid

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Fluid Therapy (Oral Rehydration Therapy)
3.	Heterologous Transplantation (Xenotransplantation)
4.	Combination Drug Therapy (Combination Chemotherapy)
5.	Parathyroidectomy