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Plicamycin

A tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA. It is used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors. Plicamycin is also used to reduce hypercalcemia, especially that due to malignancies.
Also Known As:
Mitramycin; Aureolic Acid; Mithramycin
Networked: 291 relevant articles (20 outcomes, 24 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Rohr, Jürgen: 9 articles (01/2021 - 07/2003)
2. Morís, Francisco: 8 articles (03/2021 - 01/2012)
3. Grohar, Patrick J: 5 articles (01/2021 - 06/2011)
4. Núñez, Luz-Elena: 5 articles (09/2020 - 01/2012)
5. Dasgupta, Dipak: 5 articles (03/2015 - 04/2008)
6. Tsodikov, Oleg V: 4 articles (01/2021 - 03/2016)
7. Helman, Lee J: 4 articles (01/2020 - 06/2011)
8. Gambari, Roberto: 4 articles (01/2015 - 08/2003)
9. Carbone, Giuseppina M: 4 articles (01/2012 - 07/2003)
10. Catapano, Carlo V: 4 articles (01/2012 - 07/2003)

Related Diseases

1. Neoplasms (Cancer)
2. Hypercalcemia (Milk Alkali Syndrome)
3. Osteitis Deformans (Paget's Disease of Bone)
4. Blast Crisis (Blast Phase)
5. Pancreatic Neoplasms (Pancreatic Cancer)

Related Drugs and Biologics

1. Plicamycin
2. Diphosphonates (Bisphosphonates)
3. demycarosyl-3D-digitoxosylmithramycin SK
4. DNA (Deoxyribonucleic Acid)
5. Anti-Bacterial Agents (Antibiotics)
6. Hydroxyurea (Hydrea)
7. Calcium
8. Vincristine (Oncovin)
9. Sp Transcription Factors
10. Bleomycin (Blenoxane)

Related Therapies and Procedures

1. Therapeutics
2. Drug Therapy (Chemotherapy)
3. Fluid Therapy (Oral Rehydration Therapy)
4. Combination Drug Therapy (Combination Chemotherapy)
5. Parathyroidectomy