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Minoxidil (Rogaine)

A potent direct-acting peripheral vasodilator (VASODILATOR AGENTS) that reduces peripheral resistance and produces a fall in BLOOD PRESSURE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p371)
Also Known As:
Rogaine; Loniten; Regaine; U 10858; 2,4-Pyrimidinediamine, 6-(1-piperidinyl)-, 3-oxide
Networked: 1183 relevant articles (162 outcomes, 172 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1. Sinclair, Rodney: 13 articles (06/2021 - 11/2002)
2. Trüeb, Ralph M: 10 articles (01/2022 - 06/2005)
3. Goren, A: 10 articles (01/2021 - 01/2016)
4. Shapiro, Jerry: 9 articles (06/2022 - 07/2003)
5. Goren, Andy: 9 articles (01/2022 - 05/2014)
6. Saceda-Corralo, David: 9 articles (01/2022 - 01/2019)
7. Tosti, Antonella: 8 articles (06/2021 - 07/2009)
8. Gupta, Aditya K: 7 articles (03/2022 - 11/2014)
9. Dhurat, Rachita: 7 articles (01/2022 - 07/2011)
10. McCoy, John: 7 articles (01/2022 - 05/2014)

Related Diseases

1. Alopecia (Baldness)
2. Alopecia Areata
3. Hypertension (High Blood Pressure)
4. Erectile Dysfunction
5. Inflammation (Inflammations)
06/17/1996 - "Inflammation was present in all minoxidil-treated animals, but at each dose level it was most severe in the oldest rats. "
11/01/2021 - "Since scalp inflammation was recognized as a potential physiological obstacle to the efficacy of the reference hair regrowth drug Minoxidil in vivo and since perifollicular inflammation is the hallmark of about 50%-70% follicular units in androgenetic alopecia, we decided to investigate whether the anti-inflammatory activity of LLLT/GentleWaves® device were assigned to L'Oréal by Light BioScience L.L.C., Virginia Beach, VA (US) could enhance hair regrowth activity of Minoxidil. "
01/01/2013 - "A patient self-assessment questionnaire demonstrated that the multimodal minoxidil formulation significantly (P < 0.001) slowed hair loss, increased hair growth, and improved appearance, and showed no appreciable side effects, such as itching and/or inflammation of the scalp compared with the minoxidil alone and placebo formulations. "
03/01/1988 - "Morphologic studies disclosed two types of minoxidil-induced cardiac lesions: left ventricular papillary muscle necroses, and hemorrhagic lesions which were most prominent in right atrium and were associated with inflammation, intramural hemorrhage, and fibrinoid necrosis of small arteries. "
04/01/2013 - "Mild perifollicular inflammation is seen in both androgenetic alopecia (AGA) cases and normal controls, whereas moderate or dense inflammation with concentric layers of collagen, is seen in AGA cases but only in very few normal controls, and may lessen the response to topical minoxidil. "

Related Drugs and Biologics

1. Finasteride (Propecia)
2. Solutions
3. Minoxidil (Rogaine)
4. Antihypertensive Agents (Antihypertensives)
5. Spironolactone (Aldactone)
6. Vasodilator Agents (Vasodilators)
7. Propranolol (Inderal)
8. Cetirizine (Zyrtec)
9. Adrenal Cortex Hormones (Corticosteroids)
10. Diltiazem (Cardizem)

Related Therapies and Procedures

1. Therapeutics
2. Percutaneous Collagen Induction
3. Drug Therapy (Chemotherapy)
4. Low-Level Light Therapy (LLLT)
5. Lasers (Laser)