Mikulicz' Disease

A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.

Also Known As:

Networked: 78 relevant articles (6 outcomes, 7 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Sialadenitis
2.	Dacryocystitis (Dacryoadenitis)
3.	Autoimmune Pancreatitis
4.	Glucose Intolerance
5.	Salivary Gland Diseases (Salivary Gland Disease)

Experts

1.	Takahashi, Hiroki: 15 articles (11/2014 - 04/2005)
2.	Yamamoto, Motohisa: 15 articles (11/2014 - 04/2005)
3.	Imai, Kohzoh: 11 articles (11/2014 - 04/2005)
4.	Shinomura, Yasuhisa: 11 articles (11/2014 - 10/2005)
5.	Naishiro, Yasuyoshi: 9 articles (11/2014 - 10/2005)
6.	Suzuki, Chisako: 9 articles (11/2014 - 10/2005)
7.	Himi, Tetsuo: 6 articles (11/2014 - 11/2010)
8.	Tabeya, Tetsuya: 5 articles (11/2014 - 01/2012)
9.	Ishigami, Keisuke: 4 articles (11/2014 - 01/2012)
10.	Seki, Nobuhiko: 4 articles (11/2014 - 04/2013)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mikulicz' Disease:

1.	Adrenal Cortex Hormones (Corticosteroids)IBA 08/01/2014 - "We report the case of a 48 year-old male with bilateral involvement of the salivary and lacrimal glands, which was diagnosed as Mikulicz's disease by incisional biopsy of the affected lacrimal glands, which was completely resolved after corticosteroid treatment. " 01/01/2012 - "A 66-year-old Japanese man with an 11-year history of Mikulicz's disease (MD) received continuous corticosteroid administration. " 09/01/2013 - "IgG4-related Mikulicz's disease: ultrasonography of the salivary and lacrimal glands for monitoring the efficacy of corticosteroid therapy." 08/01/2009 - "In our case, Mikulicz's disease complicated with diffuse severe interstitial nephritis was successfully treated by corticosteroid. " 01/01/2006 - "This case of Mikulicz's disease complicated with interstitial nephritis was successfully treated by high-dose corticosteroid."
2.	Immunoglobulin G (IgG)IBA 11/01/2010 - "Recent studies have revealed that Mikulicz disease (MD) differs from Sjögren syndrome and is an immunoglobulin G(4) (IgG(4))-related systemic disease. " 01/01/2004 - "The study showed that serum IgG4 concentrations are elevated in patients with Mikulicz's disease, but not in those with Sjögren's syndrome." 09/01/2021 - "The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease. " 08/01/2014 - "Specifically, Mikulicz's disease is defined by a persistent and symmetrical swelling of the lacrimal and salivary glands together with elevated serum concentration of IgG4 and tissue infiltration by IgG4 (+) plasma cells." 05/01/2013 - "IgG4 (IgG4-RD) related diseases, with a horizon not limited to Mikulicz's disease."
3.	GlucocorticoidsIBA 02/01/2006 - "However, the gland swellings in Mikulicz's disease are persistent, and its decreased secretional function is good responsiveness to glucocorticoid. " 01/01/2006 - "Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but it represents a unique condition involving persistent enlargement of the lacrimal and salivary glands characterized by few autoimmune reactions and good responsiveness to glucocorticoids, leading to the recovery of gland function. " 02/01/2005 - "Mikulicz's disease (MD) has been included within the diagnosis of primary Sjögren's syndrome (SS), but represents a unique condition involving enlargement of the lachrymal and salivary glands and characterized by few autoimmune reactions and good responsiveness to glucocorticoids. " 01/01/2020 - "Mikulicz's disease is a unique condition involving the enlargement of the lacrimal and salivary glands, similar to that observed in Sjogren's syndrome; however, Mikulicz's disease is clinically characterized by infrequent autoimmune reactions and responsiveness to glucocorticoid treatment. " 09/01/2016 - "Mikulicz disease (IgG4-related sclerosing disease) was diagnosed and she received glucocorticoid treatment. "
4.	mizoribineIBA 01/01/2010 - "The present case is the first case in which mizoribine was effective for Mikulicz's disease and IgG4-related plasmacytic syndrome." 01/01/2010 - "Treatment of Mikulicz's disease with mizoribine." 01/01/2010 - "We report a case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated with corticosteroid and mizoribine, followed by mizoribine alone. " 01/01/2010 - "A case of Mikulicz's disease, IgG4-related plasmacytic syndrome, successfully treated by corticosteroid and mizoribine, followed by mizoribine alone."
5.	Immunoglobulins (Immunoglobulin)IBA 09/01/2014 - "Recent studies revealed that Mikulicz's disease (MD) should be considered as an immunoglobulin (Ig) G4-related disease with aspects of systemic disorders involving the orbit. " 09/01/2014 - "A study of infraorbital nerve swelling associated with immunoglobulin G4 Mikulicz's disease." 01/01/2018 - "We report a case of Mikulicz disease (MD), an immunoglobulin G4 (IgG4)-related disease that affects the lacrimal and salivary glands. " 11/01/2014 - "Mikulicz's disease (MD) is an immunoglobulin (Ig) G4-related disease with systemic symptoms. " 01/01/2012 - "The characteristic features of Mikulicz's disease (MD) are diffuse enlargement of the lacrimal and submandibular glands, elevated levels of serum immunoglobulin (Ig)G4, and abundant infiltration of IgG4-positive plasmacytes into both glands. "
6.	CytokinesIBA 01/01/2012 - "This study was undertaken to examine the expression of these cytokines in patients with Mikulicz disease and patients with SS. " 01/01/2009 - "A case of Mikulicz's disease with Th2-biased cytokine profile: possible feature discriminable from Sjögren's syndrome." 01/25/2013 - "In a recent issue of Arthritis Research & Therapy, Tsuboi and colleagues demonstrated that regulatory T (Treg) cell-and T helper 2 (Th2) cell-derived cytokines contribute to the pathogenesis of Mikulicz's disease, an activation pathway that appears to be common for IgG4-RD. " 01/01/2012 - "The levels of mRNA for both Th1 and Th2 cytokines and chemokines in LSGs from patients with SS were significantly higher than in controls, while the expression of both Th2 and Treg cells was significantly higher in the patients with Mikulicz disease than in controls. " 01/01/2021 - "Ethmoid sinus mucosa specimens from 9 IgG4-RD (6 Mikulicz disease and 3 Küttner's tumor) patients with elevated serum IgG4 and IgE and from 22 control CRS patients were examined immunohistochemically for Treg cytokines (IL-10 and TGF-β), activation-induced cytidine deaminase (AID), and immunocompetent cells. "
7.	SteroidsIBA 10/01/2005 - "Beneficial effects of steroid therapy for Mikulicz's disease." 01/01/2011 - "The serum IgG4 levels decreased in all patients with AIP and Mikulicz's disease after steroid therapy. "
8.	Immunoglobulin E (IgE)IBA 01/01/2009 - "This article concerns a male patient with Mikulicz's disease (MD) accompanied with marked elevation of serum immunoglobulin (Ig)G4 and IgE levels. " 01/01/2021 - "Ethmoid sinus mucosa specimens from 9 IgG4-RD (6 Mikulicz disease and 3 Küttner's tumor) patients with elevated serum IgG4 and IgE and from 22 control CRS patients were examined immunohistochemically for Treg cytokines (IL-10 and TGF-β), activation-induced cytidine deaminase (AID), and immunocompetent cells. "
9.	AntibodiesIBA 10/01/2003 - "In 1928, Aylward reported the occurrence of CHB in two children whose mother "suffered from Mikulicz's disease." This curious clinical observation was further solidified by the 1970s, with reports of CHB in children whose mothers had autoimmune diseases and that the maternal sera contained antibodies to Ro ribonucleoproteins. " 01/01/2015 - "Anti-prohibitin antibodies were present in the sera of patients with definite autoimmune pancreatitis (25/34; 73.5%), Mikulicz's disease (8/15; 53.3%), retroperitoneal fibrosis (6/11; 54.5%), other probable IgG4-RD (26/29; 89.7%) and Sjögren's syndrome (4/30; 13.3%) but not in apparently healthy donors (1/70; 1.4%). "
10.	Fas Ligand Protein (Fas Ligand)IBA 11/01/2007 - "We have reported that Sjögren's syndrome (SS) patients with enlarged exocrine glands (EEG) formerly referred to as Mikulicz's disease were defective with Fas-ligand (FasL) expression in PBL and lacrimal glands (LGs). "

Therapies and Procedures

1.	Therapeutics 09/01/2013 - "IgG4-related Mikulicz's disease: ultrasonography of the salivary and lacrimal glands for monitoring the efficacy of corticosteroid therapy." 10/01/2005 - "Beneficial effects of steroid therapy for Mikulicz's disease." 09/01/2013 - "IgG4-related Mikulicz's disease (IgG4-MD) has been recently established as a subtype of IgG4-related diseases involving the salivary and lacrimal glands, and the diseased glands are characteristically and highly responsive to corticosteroid therapy. " 01/25/2013 - "In a recent issue of Arthritis Research & Therapy, Tsuboi and colleagues demonstrated that regulatory T (Treg) cell-and T helper 2 (Th2) cell-derived cytokines contribute to the pathogenesis of Mikulicz's disease, an activation pathway that appears to be common for IgG4-RD. " 01/01/2011 - "The serum IgG4 levels decreased in all patients with AIP and Mikulicz's disease after steroid therapy. "
2.	Ligation 09/01/1965 - "DUCT LIGATION AND SMALL-DOSE X-RADIATION: A NEW TREATMENT FOR MIKULICZ'S DISEASE."
3.	Radiotherapy 01/01/1970 - "[Results of radiotherapy in Mikulicz' disease]." 06/01/1964 - "THE TREATMENT OF MIKULICZ'S DISEASE WITH RADIATION THERAPY."
4.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 11/01/2009 - "We report the first case of Mikulicz's disease (MD) occurring 2 years after autologous peripheral blood stem cell transplantation (PBSCT) for multiple myeloma (MM). "
5.	Stem Cell Transplantation 11/01/2009 - "Mikulicz's disease with severe thrombocytopenia following autologous stem cell transplantation in a multiple myeloma patient."