Mikulicz' Disease

A chronic, benign, and usually painless inflammatory swelling of the lacrimal and salivary glands. It is considered by some to include the glandular enlargement associated with other diseases, such as Sjogren's syndrome, sarcoidosis, lupus erythematosus, etc.

Also Known As:

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Orbital Pseudotumor
2.	Thyroiditis
3.	Sialadenitis
4.	Neoplasms (Cancer)
5.	Non-Hodgkin Lymphoma (Lymphosarcoma)

Experts

1.	Deshpande, Vikram: 2 articles (03/2015 - 01/2011)
2.	Cabello, Raúl Romero: 1 article (01/2013)
3.	Ochoa, Minerva Lazos: 1 article (01/2013)
4.	Feregrino, Raúl Romero: 1 article (01/2013)
5.	López, Belem Gabiño: 1 article (01/2013)
6.	Moriyama, Masafumi: 1 article (01/2012)
7.	Nakashima, Hitoshi: 1 article (01/2012)
8.	Kubo, Yoshiaki: 1 article (01/2012)
9.	Miyake, Katsuhisa: 1 article (01/2012)
10.	Hayashida, Jun-Nosuke: 1 article (01/2012)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mikulicz' Disease:

1.	Immunoglobulin G (IgG)IBA 11/01/2010 - "Recent studies have revealed that Mikulicz disease (MD) differs from Sjögren syndrome and is an immunoglobulin G(4) (IgG(4))-related systemic disease. " 01/01/2012 - "Mikulicz disease is a unique inflammatory disorder characterized by Th2 and regulatory immune reactions that might play key roles in IgG4 production." 01/01/2012 - "Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease." 03/01/2015 - "Eosinophilic angiocentric fibrosis, Mikulicz disease and Riedel thyroiditis are also members of the family of IgG4 related disease. " 03/01/2009 - "A 72-year-old woman with Mikulicz disease with pathogically proven sclerosing sialadenitis showed systemic abnormal F-18 FDG uptake in the bilateral lacrimal and submandibular glands, pancreas, abdominal aortic wall, and a retroperitoneal fibroid mass on PET/CT scan, with marked elevation of the serum IgG4 level. "
2.	CytokinesIBA 01/01/2012 - "This study was undertaken to examine the expression of these cytokines in patients with Mikulicz disease and patients with SS. " 01/01/2012 - "The levels of mRNA for both Th1 and Th2 cytokines and chemokines in LSGs from patients with SS were significantly higher than in controls, while the expression of both Th2 and Treg cells was significantly higher in the patients with Mikulicz disease than in controls. " 01/01/2012 - "Labial salivary gland (LSG) sections from 15 patients with Mikulicz disease and 18 patients with SS were examined for subsets of the infiltrating lymphocytes, expression patterns of messenger RNA (mRNA) for cytokines/chemokines, and relationships between the IgG4:IgG ratio and the expression of mRNA for IL-4 or IL-10. "
3.	ChemokinesIBA 01/01/2012 - "The levels of mRNA for both Th1 and Th2 cytokines and chemokines in LSGs from patients with SS were significantly higher than in controls, while the expression of both Th2 and Treg cells was significantly higher in the patients with Mikulicz disease than in controls. " 01/01/2012 - "Labial salivary gland (LSG) sections from 15 patients with Mikulicz disease and 18 patients with SS were examined for subsets of the infiltrating lymphocytes, expression patterns of messenger RNA (mRNA) for cytokines/chemokines, and relationships between the IgG4:IgG ratio and the expression of mRNA for IL-4 or IL-10. "
4.	Interleukin-10 (Interleukin 10)IBA 01/01/2012 - "Labial salivary gland (LSG) sections from 15 patients with Mikulicz disease and 18 patients with SS were examined for subsets of the infiltrating lymphocytes, expression patterns of messenger RNA (mRNA) for cytokines/chemokines, and relationships between the IgG4:IgG ratio and the expression of mRNA for IL-4 or IL-10. "
5.	Interleukin-4 (Interleukin 4)IBA 01/01/2012 - "Labial salivary gland (LSG) sections from 15 patients with Mikulicz disease and 18 patients with SS were examined for subsets of the infiltrating lymphocytes, expression patterns of messenger RNA (mRNA) for cytokines/chemokines, and relationships between the IgG4:IgG ratio and the expression of mRNA for IL-4 or IL-10. "
6.	Messenger RNA (mRNA)IBA 01/01/2012 - "The levels of mRNA for both Th1 and Th2 cytokines and chemokines in LSGs from patients with SS were significantly higher than in controls, while the expression of both Th2 and Treg cells was significantly higher in the patients with Mikulicz disease than in controls. " 01/01/2012 - "Labial salivary gland (LSG) sections from 15 patients with Mikulicz disease and 18 patients with SS were examined for subsets of the infiltrating lymphocytes, expression patterns of messenger RNA (mRNA) for cytokines/chemokines, and relationships between the IgG4:IgG ratio and the expression of mRNA for IL-4 or IL-10. "
7.	Multifocal fibrosclerosisIBA 01/01/2013 - "At present, several illnesses such as Mikulicz disease, Küttner tumour, multifocal fibrosclerosis, etc, are considered to be part of the IgG4RD spectrum. "
8.	Familial primary gastric lymphomaIBA 01/01/2003 - "This case report hypothesizes that the non-Hodgkin's lymphoma (NHL), which in association with Sjögren's syndrome and Mikulicz disease in this patient comprised the Mikulicz syndrome, may have transformed into his malignant large-cell gastric lymphoma. "
9.	rituximab (Mabthera)FDA Link 01/01/2010 - "[The first experience of using rituximab in Mikulicz disease]."

Therapies and Procedures

1.	Radiotherapy 01/01/1970 - "[Results of radiotherapy in Mikulicz' disease]."