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Midodrine (Midon)

An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.

Also Known As:

Midon; Amatine; Cahill May Roberts Brand of Midodrine Monohydrochloride; Christiaens Brand of Midodrine Monohydrochloride; Gutron; Midodrin; Midodrine Hydrochloride; Midodrine Monohydrochloride; Nycomed Brand of Midodrine Monohydrochloride; ProAmatine; ST-1085; Shire Brand of Midodrine Monohydrochloride; Monohydrochloride, Midodrine; ST 1085; ST1085; Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-

Networked: 227 relevant articles (60 outcomes, 45 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Amines: 1422
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Midodrine: 227
        desglymidodrine: 2
        ST 1059: 1
        deglymidodrine
- Alcohols: 387
  - Amino Alcohols: 14
    - Ethanolamines: 12
      - Midodrine: 227
        desglymidodrine: 2
        ST 1059: 1
        deglymidodrine

Experts

1.	Du, Junbao: 9 articles (06/2015 - 01/2011)
2.	Jin, Hongfang: 8 articles (06/2015 - 01/2011)
3.	Tang, Chaoshu: 6 articles (08/2014 - 01/2011)
4.	Chen, Li: 4 articles (07/2012 - 09/2008)
5.	Tsianos, Epameinondas V: 4 articles (12/2011 - 04/2005)
6.	Platts, Steven H: 4 articles (01/2011 - 06/2004)
7.	Meck, Janice V: 4 articles (01/2011 - 06/2004)
8.	Sandroni, Paola: 3 articles (09/2015 - 11/2004)
9.	Zhang, Fengwen: 3 articles (06/2015 - 07/2012)
10.	Li, Xueying: 3 articles (04/2014 - 07/2012)

Related Diseases

1.	Orthostatic Hypotension (Postural Hypotension) 05/01/1994 - "The efficacy of Midodrine in successfully treating orthostatic hypotension secondary to autonomic failure has been shown in clinical trials. " 06/01/1988 - "Autonomic cardiovascular reflexes were significantly more impaired in patients of group II than in patients of group I. We conclude that midodrine is effective in the treatment of orthostatic hypotension only in those patients with significant preservation of autonomic reflexes. " 07/01/1993 - "We conclude that midodrine is an effective and well-tolerated treatment for moderate-to-severe orthostatic hypotension associated with autonomic failure." 06/01/1993 - "Therefore, midodrine is an effective and safe agent for the treatment of neurogenic orthostatic hypotension." 08/06/1997 - "Efficacy of midodrine for neurogenic orthostatic hypotension."
2.	Hypotension (Low Blood Pressure) 06/01/2008 - "Oral midodrine is effective for the treatment of hypotension associated with carotid artery stenting." 01/01/1997 - "In conclusion, our study has demonstrated that midodrine is a safe and effective treatment for the prevention of recurrent intradialytic hypotension if routinely premedicated before each dialysis session." 10/01/2004 - "Midodrine appears to be safe and effective for dialysis-induced hypotension: a systematic review." 08/01/1998 - "Midodrine is effective and safe therapy for intradialytic hypotension over 8 months of follow-up." 01/01/2013 - "The trial compared acupuncture versus midodrine, a drug for treating hypotension. "
3.	Vasovagal Syncope 12/01/2012 - "This study will be the first adequately powered trial to determine whether midodrine is effective in preventing vasovagal syncope. " 10/01/2010 - "Midodrine hydrochloride is safe and effective in older people with neurocardiogenic syncope." 05/01/1994 - "Midodrine's ability to vasoconstrict without increasing heart rate suggests that it might be a useful treatment for vasovagal syncope since stimulation of the Bezold-Jarisch reflex would be less likely. " 08/01/2001 - "The efficacy of midodrine for the management of patients with neurocardiogenic syncope was assessed prospectively in a randomized control study. " 07/28/2009 - "To explore the efficacy of midodrine hydrochloride in the treatment of vasovagal syncope (VVS) in children. "
4.	Ascites 02/01/2012 - "The results of this randomized pilot study suggest that midodrine plus standard medical therapy improves the systemic hemodynamics without any renal or hepatic dysfunction in these patients and is superior to standard medical therapy alone for the control of ascites." 10/01/2014 - "Clinical study on the therapeutic role of midodrine in non azotemic cirrhotic patients with tense ascites: a double-blind, placebo-controlled, randomized trial." 02/01/2007 - "This study evaluated the effects of a 7-day treatment with the alpha1-adrenergic agonist midodrine in non-azotemic cirrhotic patients with and without ascites. " 02/01/2012 - "Midodrine plus standard medical therapy was significantly superior to standard medical therapy alone in the control of ascites (p=0.013) at 3 months. " 02/01/2012 - "Forty cirrhotic patients with refractory or recurrent ascites were prospectively studied after long term administration of midodrine plus standard medical therapy (n=20) or standard medical therapy alone (n=20) in a randomized controlled trial at a tertiary centre. "
5.	Syncope (Fainting) 09/23/2014 - "Five studies reported syncope recurrence in patients with RRS showing improvement with midodrine: risk difference 37% (95% CI 20.8%-47.4%), moderate confidence. " 12/01/2012 - "Rationale for the prevention of syncope trial IV: assessment of midodrine." 07/01/1999 - "Twenty-five patients (16 women, 9 men, mean age 30 +/- 23 years) with severe recurrent syncope and a positive head upright tilt table study (refractory to or intolerant of standard therapies) were placed on midodrine 5-10 mg orally three times per day, (two patients required 15 mg/day). " 11/01/2011 - "The median number of syncopes and pre-syncopes per 3 months were also not significantly different during Midodrine and placebo treatment (0 vs. 1; P= 0.57; and 6 vs. 8; P= 0.90). " 11/01/2011 - "The proportion of patients who experienced syncopal and pre-syncopal recurrences did not differ significantly between Midodrine and placebo treatment (syncope: 48 vs. 65%, P= 0.22; pre-syncope: 74 vs. 78%, P> 0.99). "

Related Drugs and Biologics

1.	Octreotide (Sandostatin)
2.	Adrenergic alpha-Agonists (Adrenergic alpha-Agonist)
3.	Atenolol (Tenormin)
4.	Adrenergic Agonists (Adrenergic Receptor Agonist)
5.	terlipressin
6.	Clonidine (ST 155)
7.	Adrenomedullin
8.	Paroxetine (Paxil)
9.	Enalapril
10.	atomoxetine (Strattera)

Related Therapies and Procedures

1.	Renal Dialysis (Hemodialysis)
2.	Oral Administration
3.	Transplantation (Transplant Recipients)
4.	Artificial Respiration (Mechanical Ventilation)
5.	Intravenous Infusions